JIALIN WU1,2,#, ZEHONG CHEN3, WENWEI LIU1,#, YONGXIN ZHANG1, WEI FENG1, YUJIE YUAN1, JINNING YE1, LIANG WANG1, SHIRONG CAI1, YULONG HE1, SUIJING WU4,*, WU SONG1,*
Oncology Research, Vol.29, No.2, pp. 119-128, 2021, DOI:10.32604/or.2022.03178
Abstract Objective: MicroRNA-188-5p (miR-188) enhances oncologic progression in various human malignancies. This
study aimed to explore its role in colorectal cancer (CRC). Materials and Methods: Human CRC tissues paired with
normal tissues, and several CRC cell lines were utilized. Real-time quantitative PCR was applied to measure the
expression of miR-188. Overexpression and knockdown were used to access the function of miR-188 and to
investigate whether FOXL1/Wnt signaling mediates such function. The proliferation, migration and invasion of cancer
cells were evaluated by CCK8, wound-healing and transwell assays, respectively. Whether FOXL1 acted as a direct
target of miR-188 was verified by dual-luciferase reporter… More >
Login
Register
