XIAOXI WANG1, YANFEI JIA2, QIANG LI2, QIANG YANG2, YINGFENG LIU1, BEIFENG WEI1, XIANG NIU1, YINJIE ZHANG1, XIAODONG LUO2, ZIYU ZHAO1,*, PENG WANG1,*
Oncology Research, Vol.32, No.5, pp. 933-941, 2024, DOI:10.32604/or.2023.042581
Abstract MicroRNA (miR)-200b-3p has been associated with many tumors, but its involvement in pituitary adenoma is unclear. This study investigated the molecular mechanism underlying miR-200b-3p regulation in pituitary adenomas to provide a theoretical basis for treatment. Bioinformatics was used to analyze pituitary adenoma-related genes and screen new targets related to RECK and miRNA. As well, the relationship between miR-200b-3p and RECK protein was verified using a double-luciferase reporter gene assay. The expression of miR-200b-3p in clinical samples was analyzed by in situ hybridization. Transfection of the miR-200b-3p inhibitor and small interfering-RECK (si-RECK) was verified by qPCR. GH3 cell viability and proliferation… More >
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