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  • Open Access

    ARTICLE

    Targeted Silencing of Kim-1 Inhibits the Growth of Clear Cell Renal Cell Carcinoma Cell Line 786-0 In Vitro and In Vivo

    Jianping Xu, Liguo Sun, Wei Sun, Jianhai Tian, Huaiyuan Guo

    Oncology Research, Vol.26, No.7, pp. 997-1003, 2018, DOI:10.3727/096504017X15140544654946

    Abstract To investigate the effect of Kim-1 on 786-0 cells in vivo and in vitro, several experiments such as quantitative real-time PCR, Western blot, MTT, colony formation, and flow cytometry were performed to evaluate the biological behavior of 786-0 cells treated with Kim-1 siRNA. Furthermore, the tumor xenograft model was applied to BALB/c nude mice to assess the effect of Kim-1 silencing. Lentivirus-mediated RNAi effectively silenced Kim-1 in 786-0 cells. Kim-1 knockdown significantly inhibited the proliferation and colony formation ability of 786-0 cells (p < 0.01). The cell cycle of 786-0 cells was arrested in the G0/G1 phase (p < More >

  • Open Access

    REVIEW

    Carbon Monoxide Modulates Auxin Transport and Nitric Oxide Signaling in Plants under Iron Deficiency Stress

    Kaiyue Hong1,2, Yasmina Radani2, Waqas Ahmad2, Ping Li3, Yuming Luo1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.1, pp. 45-61, 2024, DOI:10.32604/phyton.2023.046389

    Abstract Carbon monoxide (CO) and nitric oxide (NO) are signal molecules that enhance plant adaptation to environmental stimuli. Auxin is an essential phytohormone for plant growth and development. CO and NO play crucial roles in modulating the plant’s response to iron deficiency. Iron deficiency leads to an increase in the activity of heme oxygenase (HO) and the subsequent generation of CO. Additionally, it alters the polar subcellular distribution of Pin-Formed 1 (PIN1) proteins, resulting in enhanced auxin transport. This alteration, in turn, leads to an increase in NO accumulation. Furthermore, iron deficiency enhances the activity of… More >

  • Open Access

    ARTICLE

    Seed Priming and Foliar Supplementation with β-aminobutyric Acid Alleviates Drought Stress through Mitigation of Oxidative Stress and Enhancement of Antioxidant Defense in Linseed (Linum usitatissimum L.)

    Tauqeer Ahmad Yasir1,2, Muhammad Ateeq1,3, Allah Wasaya1,2,*, Mubshar Hussain2, Naeem Sarwar2, Khuram Mubeen4, Mudassir Aziz4, Muhammad Aamir Iqbal5, Chukwuma C. Ogbaga6, Ibrahim Al-Ashkar7, Md Atikur Rahman8, Ayman El Sabagh9,10,*

    Phyton-International Journal of Experimental Botany, Vol.92, No.11, pp. 3113-3131, 2023, DOI:10.32604/phyton.2023.029502

    Abstract Drought is one of the critical limitations to agricultural soils and crop plants. Scarcity of water is increasing due to climate change that lead to increasing threats to global food security. Therefore, ecofriendly and cost effective strategies are highly desirable for mitigating drought stress along with sustainable and smart agricultural production. The aim of the study was to mitigate DS using seed priming and exogenous supplementation of β-aminobutyric acid (BABA) in linseed (Linum usitatissimum L.). Different doses (0, 50, 100 and 150 µM) of BABA were used for seed priming agent and foliar spraying under three… More >

  • Open Access

    VIEWPOINT

    Junctional adhesion molecule-A (JAM-A) in gynecological cancers: Current state of knowledge

    KAMILA CZUBAK-PROWIZOR*, MARIA SWIATKOWSKA

    BIOCELL, Vol.47, No.4, pp. 731-737, 2023, DOI:10.32604/biocell.2023.025677

    Abstract Junctional adhesion molecule-A (JAM-A), also known as the F11 receptor (F11R), is one of the tight junction components. JAM-A is a transmembrane glycoprotein that regulates many cellular processes, i.e., angiogenesis, leukocyte transendothelial migration, intercellular permeability, epithelial-to-mesenchymal transition, and platelet activation. Of note, it is involved in the pathogenesis of various cancer types, including gynecological cancers. Only a few studies are available about this cancer type. Observed aberrant JAM-A expression in gynecological cancers correlates with poor patient prognosis. To the best of our knowledge, conflicting JAM-A roles in various cancer types suggest that its involvement is More >

  • Open Access

    ARTICLE

    Hydrophobic Small-Molecule Polymers as High-Temperature-Resistant Inhibitors in Water-Based Drilling Fluids

    Xuyang Yao1,*, Kecheng Liu1, Zenan Zhou1, Jun Zhou1, Xianbin Huang2, Tiemei Lu1, Yongsheng Yu1, He Li2

    FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.7, pp. 1775-1787, 2023, DOI:10.32604/fdmp.2023.025843

    Abstract Water-based drilling fluids can cause hydration of the wellbore rocks, thereby leading to instability. This study aimed to synthesize a hydrophobic small-molecule polymer (HLMP) as an inhibitor to suppress mud shale hydration. An infrared spectral method and a thermogravimetric technique were used to characterize the chemical composition of the HLMP and evaluate its heat stability. Experiments were conducted to measure the linear swelling, rolling recovery rate, and bentonite inhibition rate and evaluate accordingly the inhibition performance of the HLMP. Moreover, the HLMP was characterized through measurements of the zeta potential, particle size distribution, contact angles,… More > Graphic Abstract

    Hydrophobic Small-Molecule Polymers as High-Temperature-Resistant Inhibitors in Water-Based Drilling Fluids

  • Open Access

    REVIEW

    Recent Progress of Surface Passivation Molecules for Perovskite Solar Cell Applications

    Baohua Zhao1, Teng Zhang2,*, Wenwen Liu2, Fansong Meng2, Chengben Liu1, Nuo Chen2, Zhi Li3, Zhaobin Liu3, Xiyou Li2,*

    Journal of Renewable Materials, Vol.11, No.4, pp. 1533-1554, 2023, DOI:10.32604/jrm.2022.023192

    Abstract

    Due to the solution processable nature, the prepared perovskite films are polycrystalline with considerable number of defects. These defects, especially defects at interface accelerate the carrier recombination and reduce the carrier collection. Besides, the surface defects also affect the long-term stability of the perovskite solar cells (PVSCs). To solve this problem, surface passivation molecules are introduced at selective interface (the interface between perovskite and carrier selective layer). This review summarizes recent progress of small molecules used in PVSCs. Firstly, different types of defect states in perovskite films are introduced and their effects on device performance are

    More > Graphic Abstract

    Recent Progress of Surface Passivation Molecules for Perovskite Solar Cell Applications

  • Open Access

    ARTICLE

    Grain Boundary Passivation Modulated by Molecular Doping for High-Performance Perovskite Solar Cells

    Yangyang Hao, Yue Liu*, Guorui Cao*

    Journal of Renewable Materials, Vol.10, No.12, pp. 3505-3519, 2022, DOI:10.32604/jrm.2022.023122

    Abstract Aiming to reduce the defects of perovskite film and improve carrier transport, an organic small molecule, benzo [d]isothiazol-3(2H)-one 1,1-dioxide (OBS), is introduced as an additive in the solution-processing of perovskite and prepare uniform perovskite films with a continuous distribution of OBS at grain boundaries. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy are conducted to reveal the interactions of hydrogen bonding and coordination bonding between OBS and perovskite. Various characterizations (including X-ray diffraction, UV-vis spectroscopy, electrochemical impedance spectroscopy, etc.) are conducted to uncover the effect of OBS on device performance. Consequently, high efficiency of 23.26% More > Graphic Abstract

    Grain Boundary Passivation Modulated by Molecular Doping for High-Performance Perovskite Solar Cells

  • Open Access

    ARTICLE

    An ISSA-RF Algorithm for Prediction Model of Drug Compound Molecules Antagonizing ERα Gene Activity

    Minxi Rong1, Yong Li1,*, Xiaoli Guo1,*, Tao Zong2, Zhiyuan Ma2, Penglei Li2

    Oncologie, Vol.24, No.2, pp. 309-327, 2022, DOI:10.32604/oncologie.2022.021256

    Abstract Objectives: The ERα biological activity prediction model is constructed by the compound molecular data of the anti-breast cancer therapeutic target ERα and its biological activity data, which improves the screening efficiency of anti-breast cancer drug candidates and saves the time and cost of drug development. Methods: In this paper, Ridge model is used to screen out molecular descriptors with a high degree of influence on the biological activity of Erα and divide datasets with different numbers of the molecular descriptors by screening results. Random Forest (RF) is trained by Root Mean Square Error (RMSE) and Coefficient of… More >

  • Open Access

    ARTICLE

    FCY-302, a Novel Small Molecule, Induces Apoptosis in Leukemia and Myeloma Cells by Attenuating Key Antioxidant and Mitochondrial Enzymes

    Prasanna Rajagopalan*†, Abdulrahim Hakami*†, Mohammed Ragab*, Ashraf Elbessoumy*‡

    Oncology Research, Vol.27, No.8, pp. 957-964, 2019, DOI:10.3727/096504019X15555428221646

    Abstract Arylidene analogs are well proven for biological activities. FCY-302, a novel small molecule belonging to this class, was screened for its biological efficacy in leukemia and myeloma cells. FCY-302 selectively inhibited proliferation of cancer cells with GI50 values of 395.2 nM, 514.6 Nm, and 642.4 nM in HL-60, Jurkat, and RPMI-8226 cells, respectively. The compound also increased sub-G0 peak in the cancer cell cycle and favored apoptosis determined by annexin V assay. The compound decreased the antiapoptotic Bcl-2 levels and increased proapoptotic Bax proteins in leukemia and myeloma cell lines. FCY-302 attenuated the mitochondrial membrane-bound Na+ More >

  • Open Access

    ARTICLE

    A Novel BCL-2 Inhibitor APG-2575 Exerts Synthetic Lethality With BTK or MDM2-p53 Inhibitor in Diffuse Large B-Cell Lymphoma

    Qiuyun Luo*†1, Wentao Pan*†‡1, Suna Zhou*†1, Guangfeng Wang, Hanjie Yi, Lin Zhang, Xianglei Yan*†, Luping Yuan*†, Zhenyi Liu#, Jing Wang**, Haibo Chen#, MiaoZhen Qiu*††, DaJun Yang*†‡, Jian Sun*‡‡

    Oncology Research, Vol.28, No.4, pp. 331-344, 2020, DOI:10.3727/096504020X15825405463920

    Abstract Despite therapeutic advances, the effective treatment for relapsed or refractory diffuse large B-cell lymphoma (DLBCL) remains a major clinical challenge. Evasion of apoptosis through upregulating antiapoptotic B-cell lymphoma-2 (BCL-2) family members and p53 inactivation, and abnormal activation of B-cell receptor signaling pathway are two important pathogenic factors for DLBCL. In this study, our aim is to explore a rational combination of BCL-2 inhibitor plus Bruton’s tyrosine kinase (BTK) blockade or p53 activation for treating DLBCL with the above characteristics. We demonstrated that a novel BCL-2 selective inhibitor APG-2575 effectively suppressed DLBCL with BCL-2 high expression… More >

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