LIDIA M. LOPEZ*, AMANDA PELLEGRINO DE IRALDI*, PATRICIA H. CARRIZO**, MARTA DUBIN**, ANDRÉS O.M. STOPPANI**
BIOCELL, Vol.26, No.2, pp. 237-245, 2002, DOI:10.32604/biocell.2002.26.237
Abstract CG 10-248 (3,4-dihydro-2,2 dimethyl-9-chloro-2H-naphtho[1,2b]pyran-5,6-dione), a ß-lapachone analogue, modified the ultrastructure of rat liver mitochondria in vitro, in the absence of added oxidizable substrates. The condensed mitochondrial state was replaced by the orthodox or swollen state to a significant degree. The number of modified mitochondria depended on incubation time and quinone concentration, in the 25-100 µM range. Under the same experimental conditions, mitochondrial respiration was uncoupled as indicated by the increase in the rate of succinate oxidation by controlled mitochondria in metabolic state “4” (not in state “3”), and by the activation of latent F0 F1 -ATP synthase. Taking into account… More >
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