Suha Q. AL-Shahrabalee^*, Hussein Alaa Jaber

Journal of Renewable Materials, Vol.11, No.3, pp. 1485-1498, 2023, DOI:10.32604/jrm.2023.025011 - 31 October 2022

Abstract Cancerous diseases and diseases resulting from bacteria and fungi are some of the pressures that humans face. Therefore, the development of biomaterials that are resistant to cancerous diseases, bacteria, and fungi has become one of the requirements of the medical field to extend the life of the biomaterial and fight pathogens after implanting these materials inside the human body. One of the important biomaterials used in the field of orthopedics is hydroxyapatite. In this research, Nano substituted hydroxyapatite was prepared by the wet precipitation method, including replacing 5% of the calcium ions with neodymium, cerium, More > Graphic Abstract

Lina Tang^1,2, Haiyan Hu², Yan Zhou², Yujing Huang², Yonggang Wang², Yawen Zhang², Jinrong Liang², Zhenxin Wang^1,*

Oncologie, Vol.24, No.4, pp. 913-925, 2022, DOI:10.32604/oncologie.2022.026296 - 31 December 2022

Abstract Objective: To investigate the expression of alpha–smooth muscle actin (ACTA2) in osteosarcoma tissues and its relationship with prognosis. Methods: Prognostic analysis of lung metastasis–related genes in osteosarcoma using the TCGA database. Single-cell sequencing detected the expression of ACTA2 in 11 osteosarcoma tissues. Paraf- fin-embedded tissues of 74 osteosarcoma patients treated at the Sixth People’s Hospital of Shanghai Jiao Tong University from 2014 to 2019 were collected, and tissue microarrays were prepared. ACTA2 expression was detected and scored by immunohistochemistry. According to the median value of the ACTA2 histochemical score, 74 patients were divided into two groups, the… More >

Areej A. Malibari¹, Jaber S. Alzahrani², Marwa Obayya³, Noha Negm^4,5, Mohammed Abdullah Al-Hagery⁶, Ahmed S. Salama⁷, Anwer Mustafa Hilal^8,*

CMC-Computers, Materials & Continua, Vol.73, No.3, pp. 6443-6459, 2022, DOI:10.32604/cmc.2022.031324 - 28 July 2022

Abstract Osteosarcoma is a type of malignant bone tumor that is reported across the globe. Recent advancements in Machine Learning (ML) and Deep Learning (DL) models enable the detection and classification of malignancies in biomedical images. In this regard, the current study introduces a new Biomedical Osteosarcoma Image Classification using Elephant Herd Optimization and Deep Transfer Learning (BOIC-EHODTL) model. The presented BOIC-EHODTL model examines the biomedical images to diagnose distinct kinds of osteosarcoma. At the initial stage, Gabor Filter (GF) is applied as a pre-processing technique to get rid of the noise from images. In addition,… More >

KANIZ FATEMA, ZACHARY LARSON, JARED BARROTT^*

BIOCELL, Vol.46, No.10, pp. 2177-2193, 2022, DOI:10.32604/biocell.2022.020141 - 13 June 2022

Abstract Osteosarcoma is one of the most genomically complex cancers and as result, it has been difficult to assign genomic aberrations that contribute to disease progression and patient outcome consistently across samples. One potential source for correlating osteosarcoma and genomic biomarkers is within the non-coding regions of RNA that are differentially expressed. However, it is unsurprising that a cancer classification that is fraught with genomic instability is likely to have numerous studies correlating non-coding RNA expression and function have been published on the subject. This review undertakes the formidable task of evaluating the published literature of… More >

HONG FU¹, HAOYU ZHAO¹, YALI YANG¹, SIYU WANG¹, KE DUAN^2,*, TAILIN GUO^1,*

BIOCELL, Vol.46, No.4, pp. 1067-1078, 2022, DOI:10.32604/biocell.2022.017435 - 15 December 2021

Abstract CDK5 belongs to the cyclin-dependent kinase family. CDK5 is multifunctional and plays an important role in neural differentiation. However, the role of CDK5 in osteoblastic differentiation remains unclear. The present study investigated functions and molecular mechanism of CDK5 in osteoblastic differentiation. It was found that, CDK5 inhibition promoted the expression of Runx2, ALP, OCN and OPN of MSCs and the mineralization of MC-3T3E1 cells and MSCs. CDK5 inhibition enhanced the development of F-actin, nuclear localization of β-catenin and YAP, as well as the expression of RMRP RNA. When F-actin was suppressed by Blebbistatin, the nuclear More >

FEI ZHANG^1,2,#, JIANZHONG LAI^3,#, RONGHAN HE^1,#, YI SHI⁴, KUN XU⁵, SHIHAI JIANG¹, TANGZHAO LIANG¹, WANYU ZHAO⁵, WEIDA REN⁵, LEI ZHU⁶, SONG JIN^2,*, KUN WANG^1,*

BIOCELL, Vol.46, No.3, pp. 699-709, 2022, DOI:10.32604/biocell.2022.015726 - 18 November 2021

Abstract Circular RNAs (circRNAs) are a novel class of non-coding RNA that have recently shown to have huge capabilities in the regulation of gene expression at the posttranscriptional level. Growing evidence has indicated that circRNAs could serve as competing endogenous RNAs (ceRNAs) to sponge microRNAs (miRNAs) and suppress functions of targeted miRNAs. Osteosarcoma (OS) is the most common malignant primary bone cancer. Hsa_circ_0002137 is upregulated in OS. However, the role of hsa_circ_0002137 in OS remains unclear. Using miRNA pull-down assay, we showed that cir_0002137 sponged hsa-miR-1246, and BCL2 apoptosis regulator (BCL2) mRNA was a potential target More >

Hai-Feng Zeng^*, Hai-Yan Qiu^†, Fa-Bo Feng^*

Oncology Research, Vol.29, No.1, pp. 75-75, 2021, DOI:10.3727/096504022X16420719767471

Abstract This article has no abstract. More >

Imran Ahmed^1,*, Humaira Sardar¹, Hanan Aljuaid², Fakhri Alam Khan¹, Muhammad Nawaz¹, Adnan Awais¹

CMC-Computers, Materials & Continua, Vol.69, No.3, pp. 3365-3381, 2021, DOI:10.32604/cmc.2021.018486 - 24 August 2021

Abstract Osteosarcoma is one of the most widespread causes of bone cancer globally and has a high mortality rate. Early diagnosis may increase the chances of treatment and survival however the process is time-consuming (reliability and complexity involved to extract the hand-crafted features) and largely depends on pathologists’ experience. Convolutional Neural Network (CNN—an end-to-end model) is known to be an alternative to overcome the aforesaid problems. Therefore, this work proposes a compact CNN architecture that has been rigorously explored on a Small Osteosarcoma histology Image Dataaseet (a high-class imbalanced dataset). Though, during training, class-imbalanced data can… More >

Lu Cao^1,*, Dianmei Yang², Bin Bai³

Oncologie, Vol.23, No.1, pp. 149-158, 2021, DOI:10.32604/oncologie.2021.014151 - 30 March 2021

Abstract Objective: This study aimed to explore the miR-1247-mediated promotion of osteosarcoma (OS) cell proliferation by SOX9. Methods: We recruited 97 OS patients admitted to our hospital (the observation group, OG) and 82 healthy people undergoing physical examinations (the control group, CG) over the same period into this study. The expression of miR-1247 and SOX9 in human OS cells in vitro was tested to determine the effect of miR-1247 and SOX9 on OS and to analyze the relationship between miR-1247 and SOX9. Results: We detected lowly expressed miR-1247 and highly expressed SOX9 in the peripheral blood of OS patients… More >

MERVIN BURNETT¹, VITO RODOLICO², FAN SHEN¹, ROGER LENG¹, MINGYONG ZHANG³, DAVID D. EISENSTAT^4,5, CONSOLATO SERGI^1,3,6,*

BIOCELL, Vol.45, No.1, pp. 17-26, 2021, DOI:10.32604/biocell.2021.013973 - 26 January 2021

Abstract MicroRNAs (miRNAs) are small single-stranded, non-coding RNA molecules involved in the pathogenesis and progression of cancer, including osteosarcoma. We aimed to clarify the pathways involving miRNAs using new bioinformatics tools. We applied WikiPathways and PathVisio, two open-source platforms, to analyze miRNAs in osteosarcoma using miRTar and ONCO.IO as integration tools. We found 1298 records of osteosarcoma papers associated with the word “miRNA”. In osteosarcoma patients with good response to chemotherapy, miR-92a, miR- 99b, miR-193a-5p, and miR-422a expression is increased, while miR-132 is decreased. All identified miRNAs seem to be centered on the TP53 network. This is the More >