WEN GE^1,2,#, YA LI^1,2,#, YUTING RUAN^1,2, NINGXIA WU^1,2, PEI MA^3,4, TONGPENG XU^3,4, YONGQIAN SHU^3,4, YINGWEI WANG^1,2, WEN QIU^1,2, CHENHUI ZHAO^3,4,*

Oncology Research, Vol.32, No.4, pp. 625-641, 2024, DOI:10.32604/or.2023.031053

Abstract The cancer cell metastasis is a major death reason for patients with non-small cell lung cancer (NSCLC). Although researchers have disclosed that interleukin 17 (IL-17) can increase matrix metalloproteinases (MMPs) induction causing NSCLC cell metastasis, the underlying mechanism remains unclear. In the study, we found that IL-17 receptor A (IL-17RA), p300, p-STAT3, Ack-STAT3, and MMP19 were up-regulated both in NSCLC tissues and NSCLC cells stimulated with IL-17. p300, STAT3 and MMP19 overexpression or knockdown could raise or reduce IL-17-induced p-STAT3, Ack-STAT3 and MMP19 level as well as the cell migration and invasion. Mechanism investigation revealed that STAT3 and p300 bound… More > Graphic Abstract

A. Benabid Najjar^1,*, N. AlSahly², R. AlShamass¹, M. Hosny²

CMC-Computers, Materials & Continua, Vol.67, No.1, pp. 1169-1189, 2021, DOI:10.32604/cmc.2021.014140

Abstract Technology has tremendously contributed to improving communication and facilitating daily activities. Brain-Computer Interface (BCI) study particularly emerged from the need to serve people with disabilities such as Amyotrophic Lateral Sclerosis (ALS). However, with the advancements in cost-effective electronics and computer interface equipment, the BCI study is flourishing, and the exploration of BCI applications for people without disabilities, to enhance normal functioning, is increasing. Particularly, the P300-based spellers are among the most promising applications of the BCI technology. In this context, the region-based paradigm for P300 BCI spellers was introduced in an effort to reduce the crowding effect and adjacency problem… More >