Mong-Fong Horng^1,#, Thanh-Lam Nguyen^1,#, Thanh-Tuan Nguyen^2,*, Chin-Shiuh Shieh^1,*, Lan-Yuen Guo³, Chen-Fu Hung⁴, Chun-Chih Lo¹

CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.1, 2026, DOI:10.32604/cmes.2025.075064 - 29 January 2026

Abstract The global population is rapidly expanding, driving an increasing demand for intelligent healthcare systems. Artificial intelligence (AI) applications in remote patient monitoring and diagnosis have achieved remarkable progress and are emerging as a major development trend. Among these applications, mouth motion tracking and mouth-state detection represent an important direction, providing valuable support for diagnosing neuromuscular disorders such as dysphagia, Bell’s palsy, and Parkinson’s disease. In this study, we focus on developing a real-time system capable of monitoring and detecting mouth state that can be efficiently deployed on edge devices. The proposed system integrates the Facial… More >

Katerina Ondraskova^1,2, Matous Cwik³, Ondrej Horky⁴, Jitka Berkovcova⁴, Jitka Holcakova¹, Martin Bartosik¹, Tomas Kazda⁵, Klara Mrazova^1,6, Michal Uher⁷, Igor Kiss³, Roman Hrstka^1,3,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.070116 - 19 January 2026

Abstract Objectives: Cancer treatment relies heavily on accurate diagnosis and effective monitoring of the disease. These processes often involve invasive procedures, such as colonoscopy, to detect malignant tissues, followed by molecular analyses to determine relevant biomarkers. This study aimed to evaluate the clinical performance of droplet digital PCR (ddPCR) for detecting Kirsten Rat Sarcoma Viral Proto-Oncogene (KRAS), Neuroblastoma RAS Viral Oncogene Homolog (NRAS), and B-Raf Murine Sarcoma Viral Oncogene Homolog B (BRAF) mutations in circulating tumor DNA (ctDNA) from colorectal cancer patients using liquid biopsy. Methods: ctDNA was isolated from colorectal cancer (CRC) patients (n = 110) and analyzed for KRAS, BRAF,… More >

Marco Siringo^1,2,#,*, Michela De Meo^1,#, Alain Jonathan Gelibter³, Chiara Nicolazzo^4,5,§, Paola Gazzaniga^5,§

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.069832 - 19 January 2026

Abstract Objectives: Although immune checkpoint inhibitors (ICIs) and targeted therapies have reshaped treatment non-small cell lung cancer (NSCLC) paradigms, prognosis remains poor for many patients due to delayed diagnosis and resistance mechanisms. Liquid biopsy offers a minimally invasive approach to monitoring tumor evolution. Among circulating biomarkers, circulating tumor cells (CTCs) and cancer-associated macrophage-like cells (CAM-Ls) may provide complementary prognostic insights. The study aimed to evaluate the prognostic role of CTC and CAM-Ls dynamic in metastatic NSCLC patients. Methods: We retrospectively analyzed 77 patients with metastatic NSCLC who underwent CTC and CAM-L evaluation via the CellSearch® system… More >

Ahsan Habib Siam¹, Md. Ehsanul Haque¹, Fahmid Al Farid², Anindita Sutradhar³, Jia Uddin^4,*, Sarina Mansor^2,*

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.069718 - 12 January 2026

Abstract As healthcare systems increasingly embrace digitalization, effective management of electronic health records (EHRs) has emerged as a critical priority, particularly in inpatient settings where data sensitivity and real-time access are paramount. Traditional EHR systems face significant challenges, including unauthorized access, data breaches, and inefficiencies in tracking follow-up appointments, which heighten the risk of misdiagnosis and medication errors. To address these issues, this research proposes a hybrid blockchain-based solution for securely managing EHRs, specifically designed as a framework for tracking inpatient follow-ups. By integrating QR code-enabled data access with a blockchain architecture, this innovative approach enhances… More >

Sarra B. Shakartalla^1,2,3, Iman M. Talaat^1,2,4,*, Nival Ali¹, Shahenaz S. Salih^1,5, Zainab M. Al Shareef^1,2, Noura Alkhayyal⁶, Riyad Bendardaf^2,7,*, Sameh S. M. Soliman^1,8,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070808 - 30 December 2025

Abstract Objectives: Breast cancer (BC) is the leading cause of cancer-related mortality in women, largely due to metastasis. This study aims to explore the role of purine nucleoside phosphorylase (PNP), a key enzyme in purine metabolism, in the aggressiveness and metastatic behavior of BC. Methods: A comprehensive analysis was performed using in silico transcriptomic data (n = 2509 patients), immunohistochemical profiling of BC tissues (n = 103), and validation through western blotting in multiple BC cell lines. Gene expression and survival analyses were conducted using Tumor Immune Estimation Resource (TIMER), Gene Expression Profiling Interactive Analysis 2 (GEPIA2), and… More >

Jing Cai^1,#, Haoyun Zhu^1,#, Weiling Guo¹, Ting Huang¹, Pangzhou Chen^1,2, Wen Zhou¹, Ziyun Guan^1,3,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069902 - 30 December 2025

Abstract Background: Therapeutic responses of breast cancer vary among patients and lead to drug resistance and recurrence due to the heterogeneity. Current preclinical models, however, are inadequate for predicting individual patient responses towards different drugs. This study aimed to investigate the patient-derived breast cancer culture models for drug sensitivity evaluations. Methods: Tumor and adjacent tissues from female breast cancer patients were collected during surgery. Patient-derived breast cancer cells were cultured using the conditional reprogramming technique to establish 2D models. The obtained patient-derived conditional reprogramming breast cancer (CRBC) cells were subsequently embedded in alginate-gelatin methacryloyl hydrogel microspheres… More >

Elçin Alaçam^1,*, Mualla Yılmaz²

International Journal of Mental Health Promotion, Vol.27, No.12, pp. 1989-2005, 2025, DOI:10.32604/ijmhp.2025.071033 - 31 December 2025

Abstract Background: Post-cesarean surgical site infection is a frequent complication with significant consequences for maternal, physical, and psychological well-being. This study explored women’s lived experiences of post-cesarean surgical site infection, focusing on emotional responses, treatment experiences, and perceived psychosocial impact. Methods: A qualitative study was conducted using thematic analysis of semi-structured interviews with 23 patients hospitalized due to post-cesarean surgical site infection, selected through purposeful sampling between 15 August 2022, and 15 January 2024. Results: The mean age of the participants in the study was 28.69 ± 5.07 years. Of them, 13 were high school graduates, and 22… More >

Vinay Durbhakula^1,*, Ziv Savin¹, Einat Savin-Shalom², Stephanie L. Gold², Kavita Gupta¹, Eve Frangopoulos¹, Blair Gallante¹, William M. Atallah¹, Mantu Gupta¹

Canadian Journal of Urology, Vol.32, No.6, pp. 659-668, 2025, DOI:10.32604/cju.2025.067614 - 30 December 2025

Abstract Background: A well-established correlation exists between Inflammatory Bowel Disease (IBD) and urolithiasis. However, the influence of surgical history on the severity of urolithiasis in IBD patients remains underexplored. This study aims to investigate the association between gastrointestinal (GI) bowel resection and urolithiasis severity in patients with IBD. Methods: This retrospective cohort study analyzed 42 patients diagnosed with both IBD and urolithiasis between 2016 and 2024. Patients were categorized based on their history of bowel resection. Primary outcomes included maximal stone burden, need for urolithiasis surgery, and stone recurrence. Secondary outcomes were stone-related clinical events, multiple… More >

Taras Shatylko^1,*, Ruslan Safiullin¹, Safar Gamidov^1,2, Tatiana Ivanets¹, Ramazan Mammaev², Kanan Guluzade², Ilia Rodin³, Gennadiy Sukhikh¹

Canadian Journal of Urology, Vol.32, No.6, pp. 561-568, 2025, DOI:10.32604/cju.2025.064572 - 30 December 2025

Abstract Background: Some patients with prostate cancer have elevated gonadotropin levels. It is unknown, however, whether this condition directly influences carcinogenesis in the prostate. It is also unknown whether any specific hormone levels are useful to predict aggressive disease. The potential role of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in prostate physiology is widely discussed. The study aimed to evaluate whether patients with this endocrine pattern have different outcomes following radical prostatectomy. Methods: This was a prospective cohort study of consecutive patients undergoing robot-assisted radical prostatectomy at the Andrology and Urology Department, National Medical Research… More >

Ankith P. Maremanda^*, Anna Faris, Benjamin N. Breyer

Canadian Journal of Urology, Vol.32, No.6, pp. 545-550, 2025, DOI:10.32604/cju.2025.064433 - 30 December 2025

Abstract We describe the history of Patient-Reported Outcome Measures (PROMs) in medicine, with a focus on the development and use of the International Index of Erectile Function (IIEF) in urologic practice. PROMs emerged in the 1970s with tools like the Sickness Impact Profile, designed to capture patients’ perspectives on how disease affects daily life. In the 1990s, PROMs entered urology with the creation of the International Prostate Symptom Score (IPSS) and the IIEF, developed in 1992 and 1997, respectively. As organizations such as the National Institutes of Health began prioritizing PROMs for evaluating sexual function, the More >