YAN ZHANG, HEYANG ZHANG, JING WANG, XIN WEI, YI QU, FENG XU, LIJUN ZHANG^*

Oncology Research, Vol.32, No.5, pp. 955-963, 2024, DOI:10.32604/or.2023.043922

Abstract Background: Bortezomib results in peripheral neuropathy (PN) in approximately 50% of patients, during multiple myeloma (MM) treatment, a complication known as Bortezomib-induced peripheral neuropathy (BIPN). The drug response varies among individuals. Genetic factor may play an important role in BIPN. Methods: A next-generation sequencing (NGS) panel containing 1659 targets from 233 genes was used to identify risk variants for developing BIPN in 204 MM patients who received bortezomib therapy. mRNA expression of MTHFR and ALDH1A1 in 62 peripheral blood samples was detected by real-time quantitative PCR (RT-qPCR). Serum homocysteine (Hcy) levels were detected in 40 samples by chemiluminescent microparticle immunoassay… More > Graphic Abstract

JIYU WANG^1,2, HUIXIA LI^1,2, DEYUAN ZHOU^1,2, LIHONG BAI^1,2, KEJING TANG^1,2,3,*

BIOCELL, Vol.48, No.4, pp. 623-637, 2024, DOI:10.32604/biocell.2024.030420

Abstract Background: For patients with lung cancer, timely identification of new lung lesions as infectious or non-infectious, and accurate identification of pathogens is very important in improving OS of patients. As a new auxiliary examination, metagenomic next-generation sequencing (mNGS) is believed to be more accurate in diagnosing infectious diseases in patients without underlying diseases, compared with conventional microbial tests (CMTs). We designed this study to find out whether mNGS has better performance in distinguishing infectious and non-infectious diseases in lung cancer patients using bronchoalveolar lavage fluid (BALF). Materials and Methods: This study was a real-world retrospective review based on electronic medical… More >

Guilhem Paillard-Brunet^*, Audrey Couillet

Psycho-Oncologie, Vol.18, No.1, pp. 23-31, 2024, DOI:10.32604/po.2023.047888

Abstract Cette étude qualitative visait à recueillir chez les professionnels d’un Centre de Lutte Contre le Cancer les attentes et les réticences qu’ils pouvaient avoir vis-à-vis des interventions de pair-aidance. Des entretiens individuels semi-structurés ont été menés auprès de 12 professionnels issus de professions différentes. Une retranscription intégrale des entretiens puis une analyse thématique de leur contenu ont été conduites. L’analyse des données a permis de faire émerger trois thèmes principaux quant aux attentes exprimées par les soignants : le besoin d’un accompagnement plus soutenant des patients, rompre leur isolement dans la maladie et enrichir le réseau de soins. L’analyse a… More >

Wanxiu Zhu^*

Psycho-Oncologie, Vol.18, No.1, pp. 69-77, 2024, DOI:10.32604/po.2023.046593

Abstract Exploring the relationship between social support and the mental health of cancer patients is a vital endeavor for enhancing mental well-being. The objective of this study was to explore the relationship between social support and psychological well-being in cancer patients and to provide new empirical evidence for psychological improvement in cancer patients. This research holds significant practical implications for optimizing China’s public health system and strengthening the development of a healthy China. Using data from the 2018 China Health and Retirement Longitudinal Study (CHARLS) database, we empirically examined the influence of social support on the mental health of cancer patients.… More >

Maria Inês Clara^1,2,3,*, Maria Cristina Canavarro^2,3, Ana Severina⁴, Susana Ramos⁴, Carla Rafael⁴, Ana Allen Gomes^1,2,3

Psycho-Oncologie, Vol.18, No.1, pp. 49-57, 2024, DOI:10.32604/po.2023.044320

Abstract Objectif: L’objectif de l’étude fut de comparer la fatigue ressentie par les patients du cancer par rapport à celle de la population en générale, ainsi que d’examiner les facteurs de risque psychobiologiques associés à la fatigue. Matériel et méthodes: Dans cette étude quantitative et transversale, nous avons analysé les indicateurs cliniques et sociodémographiques de 389 participants (68.38% de femmes) : 148 patients du cancer sous traitement actif, 55 patients dans l’après-traitement d’un cancer, 75 patients atteints d’une autre maladie chronique et 111 personnes en bonne santé. Résultats: La fatigue s’exprimait de manière différente chez les patients ayant des antécédents de… More >

Julien Biaudet^1,*, Lisa Laroussi-Libeault², Mauricette Michallet³, Laurie Panse², Raymond Merle⁴

Psycho-Oncologie, Vol.18, No.1, pp. 17-22, 2024, DOI:10.32604/po.2023.043536

Abstract Cet article vise à partager une expérience innovante d’organisation et de financement de la recherche ayant impliqué les premiers concernés : les patients. Le groupe de travail « ECLAIR » du Cancéropôle Lyon Auvergne-Rhône-Alpes (CLARA) a été créé en fin d’année 2020 dans le but de contribuer à l’élaboration d’un appel à projets portant sur l’expérience patient en cancérologie, ouvert en janvier 2021. Constitué au départ de 8 membres dont 7 patients, coordonné par un chef de projets du CLARA, le groupe de travail ECLAIR a activement contribué à l’écriture du cahier des charges de l’appel à projets, à l’élaboration… More >

Lennize Pereira Paulo^1,2,*, Catherine Tourette-Turgis^1,2, Marie-Paule Vannier^1,3

Psycho-Oncologie, Vol.18, No.1, pp. 9-15, 2024, DOI:10.32604/po.2023.042981

Abstract Cet article présente l’histoire et les enjeux de la diplomation des patients en la posant comme un dispositif de soutien de l’engagement des patients et des usagers du système de santé. Un ensemble de lois relatives aux droits des malades et à la qualité du système de santé permettent l’intégration des patients dans le système de santé mais elles se heurtent à la non-préparation des institutions à ce nouveau champ de pratiques. La diplomation des patients nécessite des transformations dans les modes d’accueil et de financement des universités et aussi dans les méthodes pédagogiques qui doivent être adaptées à l’accueil… More >

Sipawath Khamplod^1,2, Yodying Kaolawanich^1,2, Khemajira Karaketklang³, Nithima Ratanasit^1,2,*

Congenital Heart Disease, Vol.19, No.1, pp. 93-105, 2024, DOI:10.32604/chd.2024.048631

Abstract Background: Atrial septal defect (ASD) is a common form of adult congenital heart disease that can lead to long-term adverse outcomes if left untreated. Early closure of ASD has been associated with excellent outcomes and lower complication rates. However, there is limited evidence regarding the prognosis of ASD closure in older adults. This study aims to evaluate the mortality rates in older ASD patients with and without closure. Methods: A retrospective cohort study was conducted on patients aged 40 years or older with ASD between 2001 and 2017. Patients were followed up to assess all-cause mortality. Univariable and multivariable analyses… More > Graphic Abstract

Molly Clarke^1,*, Karin Hamann², Nancy Klein², Laura Olivieri³, Yue-Hin Loke²

Congenital Heart Disease, Vol.19, No.1, pp. 5-17, 2024, DOI:10.32604/chd.2024.046328

Abstract Background: Patients with congenital heart disease (CHD) will transition to lifelong adult congenital cardiac care. However, their structural heart disease is challenging to convey via two-dimensional drawings. This study utilized a tele-educational environment, with personalized three-dimensional (3D) modeling and health Details (3D + Details = “4D”), to improve actual and perceived knowledge, both important components of transition readiness in CHD patients. Methods: Participants aged ≥13 years with a history of CHD and cardiac magnetic resonance imaging (MRI) studies were eligible. Cardiac MRI datasets were then used to segment and create 3D heart models (using Mimics, Materialize Inc.). Participants first completed… More >

MENNA AL-ADL^1,*, MAGDY M. YOUSSEF¹, AHMED EL-SEBAIE², SHERIF REFAAT³, AFAF EL-SAID⁴

Oncology Research, Vol.32, No.4, pp. 785-797, 2024, DOI:10.32604/or.2024.047021

Abstract Cytochromes P450 (CYPs) play a prominent role in catalyzing phase I xenobiotic biotransformation and account for about 75% of the total metabolism of commercially available drugs, including chemotherapeutics. The gene expression and enzyme activity of CYPs are variable between individuals, which subsequently leads to different patterns of susceptibility to carcinogenesis by genotoxic xenobiotics, as well as differences in the efficacy and toxicity of clinically used drugs. This research aimed to examine the presence of the CYP2B6*9 polymorphism and its possible association with the incidence of B-CLL in Egyptian patients, as well as the clinical outcome after receiving cyclophosphamide chemotherapy. DNA… More > Graphic Abstract