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  • Open Access

    ARTICLE

    Biomechanical Study of Different Scaffold Designs for Reconstructing a Traumatic Distal Femur Defect Using Patient-Specific Computational Modeling

    Hsien-Tsung Lu1,2, Ching-Chi Hsu3,*, Qi-Quan Jian3, Wei-Ting Chen4

    CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.2, pp. 1883-1898, 2025, DOI:10.32604/cmes.2025.057675 - 27 January 2025

    Abstract Reconstruction of a traumatic distal femur defect remains a therapeutic challenge. Bone defect implants have been proposed to substitute the bone defect, and their biomechanical performances can be analyzed via a numerical approach. However, the material assumptions for past computational human femur simulations were mainly homogeneous. Thus, this study aimed to design and analyze scaffolds for reconstructing the distal femur defect using a patient-specific finite element modeling technique. A three-dimensional finite element model of the human femur with accurate geometry and material distribution was developed using the finite element method and material mapping technique. An… More > Graphic Abstract

    Biomechanical Study of Different Scaffold Designs for Reconstructing a Traumatic Distal Femur Defect Using Patient-Specific Computational Modeling

  • Open Access

    ARTICLE

    A Blockchain-Based Access Management System for Enhanced Patient Privacy and Secure Telehealth and Telemedicine Data

    Ayoub Ghani1,*, Ahmed Zinedine1, Mohammed El Mohajir2

    Intelligent Automation & Soft Computing, Vol.40, pp. 75-98, 2025, DOI:10.32604/iasc.2025.060143 - 23 January 2025

    Abstract The Internet of Things (IoT) advances allow healthcare providers to distantly gather and immediately analyze patient health data for diagnostic purposes via connected health devices. In a COVID-19-like pandemic, connected devices can mitigate virus spread and make essential information, such as respiratory patterns, available to healthcare professionals. However, these devices generate vast amounts of data, rendering them susceptible to privacy breaches, and data leaks. Blockchain technology is a robust solution to address these issues in telemedicine systems. This paper proposes a blockchain-based access management solution to enhance patient privacy and secure telehealth and telemedicine data.… More >

  • Open Access

    REVIEW

    Three-dimensional models: from cell culture to Patient-Derived Organoid and its application to future liposarcoma research

    SAYUMI TAHARA1, SYDNEY RENTSCH1, FERNANDA COSTAS CASAL DE FARIA1, PATRICIA SARCHET1, ROMA KARNA1, FEDERICA CALORE2,*, RAPHAEL E. POLLOCK1

    Oncology Research, Vol.33, No.1, pp. 1-13, 2025, DOI:10.32604/or.2024.053635 - 20 December 2024

    Abstract Liposarcoma is one of the most common soft tissue sarcomas, however, its occurrence rate is still rare compared to other cancers. Due to its rarity, in vitro experiments are an essential approach to elucidate liposarcoma pathobiology. Conventional cell culture-based research (2D cell culture) is still playing a pivotal role, while several shortcomings have been recently under discussion. In vivo, mouse models are usually adopted for pre-clinical analyses with expectations to overcome the issues of 2D cell culture. However, they do not fully recapitulate human dedifferentiated liposarcoma (DDLPS) characteristics. Therefore, three-dimensional (3D) culture systems have been the recent… More >

  • Open Access

    ARTICLE

    The impact of alpha-fetoprotein (AFP), child-turcotte-pugh (CTP) score and disease staging on the survival of hepatocellular carcinoma (HCC) patients: a retrospective cohort from single oncology center

    NASSER MULLA1,*, YOUSEF KATIB2, ASIM M. ALMUGHAMSI3, DUAA S. ALKHAYAT1, MOHAMED MOSAAD1,4, SAMIR T. ALFOTIH5, RAWAN ALAOFI6

    Oncology Research, Vol.33, No.1, pp. 149-160, 2025, DOI:10.32604/or.2024.050903 - 20 December 2024

    Abstract Background: Hepatocellular carcinoma (HCC) is the most common cause of cancer-related death in Saudi Arabia. Our study aimed to investigate the patterns of HCC and the effect of TNM staging, Alfa-fetoprotein (AFP), and Child-Turcotte Pugh (CTP) on patients’ overall survival (OS). Methods: A retrospective analysis was conducted on 43 HCC patients at a single oncology center in Saudi Arabia from 2015 to 2020. All patients had to fulfill one of the following criteria: (a) a liver lesion reported as definitive HCC on dynamic imaging and/or (b) a biopsy-confirmed diagnosis. Results: The mean patient age of all… More >

  • Open Access

    ARTICLE

    Genetic signatures of ERCC1 and ERCC2 expression, along with SNPs variants, unveil favorable prognosis in SCLC patients undergoing platinum-based chemotherapy

    ENRICO CALIMAN1,2, SARA FANCELLI1,2, FEDERICO SCOLARI3, ADRIANO PASQUI4, CLARA MANNESCHI4, DANIELE LAVACCHI1, FRANCESCA MAZZONI4, FRANCESCA GENSINI5, VALERIA PASINI6, CAMILLA EVA COMIN2,7, LUCA VOLTOLINI2,8, SERENA PILLOZZI1,2,*, LORENZO ANTONUZZO1,2,4

    Oncology Research, Vol.33, No.1, pp. 45-55, 2025, DOI:10.32604/or.2024.050161 - 20 December 2024

    Abstract Background: Platinum chemotherapy (CT) remains the backbone of systemic therapy for patients with small-cell lung cancer (SCLC). The nucleotide excision repair (NER) pathway plays a central role in the repair of the DNA damage exerted by platinum agents. Alteration in this repair mechanism may affect patients’ survival. Materials and Methods: We conducted a retrospective analysis of data from 38 patients with extensive disease (ED)-SCLC who underwent platinum-CT at the Clinical Oncology Unit, Careggi University Hospital, Florence (Italy), from 2015 to 2020. mRNA expression analysis and single nucleotide polymorphism (SNP) characterization of three NER pathway genes—namely ERCC1, ERCC2,… More >

  • Open Access

    ARTICLE

    Efficacy of Intravenous Treprostinil in High-Risk Single Ventricle Patients Undergoing Glenn Procedure

    Xiaofeng Wang1,#, Xingwei Chen2,#, Shilin Wang1, Xia Li1, Zhongyuan Lu1, Wenlong Wang1, Xu Wang1,*

    Congenital Heart Disease, Vol.19, No.5, pp. 489-498, 2024, DOI:10.32604/chd.2024.054441 - 31 December 2024

    Abstract Objective: Pulmonary hypertension is a crucial factor affecting the recovery after Glenn procedure. This study explores the effects of intravenous treprostinil on hemodynamic status and hospital postoperative recovery under different administration strategies. Methods: We retrospectively included pediatric patients admitted to Fuwai Hospital from 2019 to 2022 who underwent the Glenn procedure and had intraoperative measurements of mean pulmonary artery pressure (mPAP) >15 mmHg postoperatively. Patients with non-anatomical single ventricle physiology undergoing the Glenn procedure and those requiring postoperative extracorporeal membrane oxygenation were excluded. Due to the standardized use of treprostinil in our center starting in… More >

  • Open Access

    ARTICLE

    Psychological Distress in the Association between Medical Education Changes and Clinical Learning Worry among Students Receiving Clinical Education during the COVID-19 Pandemic in Taiwan

    Shikha Kukreti1,#, Min-Chi Hsieh2,#, Musheer A. Aljaberi3, Ru-Yi Huang4,5,6, I-Ting Hwang7, Carol Strong2, Jung-Sheng Chen8, Ming-Ta Hsieh9,10,*, Mark D. Griffiths11, Chung-Ying Lin12,13,*, Nai-Ying Ko1

    International Journal of Mental Health Promotion, Vol.26, No.12, pp. 987-996, 2024, DOI:10.32604/ijmhp.2024.057708 - 31 December 2024

    Abstract Background: The COVID-19 pandemic profoundly impacted medical education and caused psychological distress and worry about clinical learning for those who received clinical medical education during this period. Although the acute phase of COVID-19 has now ended, understanding its impact is essential for strengthening medical system preparedness. Therefore, the present study examined the association between changes in medical education and worry about clinical learning, considering the mediating role of psychological distress among participants who received clinical training. Methods: A cross-sectional online survey was conducted with 542 post-graduate year (PGY) doctors and allied health students from the… More >

  • Open Access

    ARTICLE

    Perspectives and Challenges of Family Members in Providing Mental Support to Cancer Patients: A Qualitative Study in Beijing, China

    Wei Wang1,2, Lan Li3,*

    Psycho-Oncologie, Vol.18, No.4, pp. 257-269, 2024, DOI:10.32604/po.2024.057004 - 04 December 2024

    Abstract This study explores the perspectives and challenges faced by family members providing mental support to cancer patients in Beijing, China. The primary objective is to understand the emotional and practical roles family members undertake and the difficulties they encounter. Utilizing a qualitative research design, data were collected through semi-structured interviews with family caregivers of cancer patients. Thematic analysis revealed several key themes: the dual burden of emotional support and caregiving responsibilities, the impact on daily life and personal well-being, the role and effectiveness of external support systems, perceptions of medical staff support, and the common More >

  • Open Access

    REVIEW

    Progress in Research on the Impact of Religious Psychological Coping on the Holistic Well-Being of Cancer Patients and Relevant Factors

    Jing Li1, Minghui Li2,*, Guanghuan Xie3

    Psycho-Oncologie, Vol.18, No.4, pp. 249-255, 2024, DOI:10.32604/po.2024.056994 - 04 December 2024

    Abstract This study reviews the historical development, current applications, and multifaceted impacts of religious psychological coping on the physical and mental health of cancer patients. As a method for coping with life’s pressures through religious beliefs or activities, religious psychological coping has been proven to alleviate the negative emotions of cancer patients and enhance their spiritual well-being and quality of life (QOL). Research indicates that religious faith can alleviate the physical symptoms of cancer patients, extend survival time, reduce the fear of death, assist in coping with treatment side effects, and improve self-efficacy and overall quality More >

  • Open Access

    ARTICLE

    The Impact of Nursing Staff’s Work Attitude on the Fear of Patients Recovering from Benign Tumors: Family Support as a Mediating Variable

    Chengzhe Guo1, Aihua Cheng2,*, Jian Chen2, Gaojie Cheng3

    Psycho-Oncologie, Vol.18, No.4, pp. 291-303, 2024, DOI:10.32604/po.2024.054446 - 04 December 2024

    Abstract The perception of nursing staff’s attitude influences patient fear. Understanding this dynamic is crucial for fostering a supportive environment conducive to patient well-being and effective healthcare practices. The purpose of this research is to investigate how the attitudes and behaviours of nursing staff influence the fear and anxiety levels of patients recovering from benign tumors, aiming to improve patient care and recovery outcomes. Data was collected from a sample of 100 participants, comprising 20 nursing staff and 80 patients recovering from benign tumors. Surveys were administered to gather quantitative data on attitudes and fear levels.… More >

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