LU ZHANG^*, JINGUO CHU^*, YUSHAN YU

Oncology Research, Vol.32, No.4, pp. 703-716, 2024, DOI:10.32604/or.2023.030988

Abstract Background: Limited research has been conducted on the influence of autophagy-associated long non-coding RNAs (ARLncRNAs) on the prognosis of hepatocellular carcinoma (HCC). Methods: We analyzed 371 HCC samples from TCGA, identifying expression networks of ARLncRNAs using autophagy-related genes. Screening for prognostically relevant ARLncRNAs involved univariate Cox regression, Lasso regression, and multivariate Cox regression. A Nomogram was further employed to assess the reliability of Riskscore, calculated from the signatures of screened ARLncRNAs, in predicting outcomes. Additionally, we compared drug sensitivities in patient groups with differing risk levels and investigated potential biological pathways through enrichment analysis, using consensus clustering to identify subgroups… More >

Xiaodan Wang^1,*, Zheng Xie², Guiping Du³

International Journal of Mental Health Promotion, Vol.26, No.2, pp. 149-160, 2024, DOI:10.32604/ijmhp.2023.030755

Abstract Research purpose: This study implemented somatosensory music therapy on patients with depressive disorders, and explored the effects of somatosensory music therapy on the degree of depression, positive and negative emotions, intuitive stress and autonomic nervous function of patients. Research method: We collected 66 patients diagnosed with depression from the Department of Psychological Medicine of Henan Provincial People’s Hospital, and divided them into a control group and an intervention group according to the random number table, with 33 people in each group. The control group received routine psychiatric treatment and nursing. On the basis of the control group, the intervention group… More >

QIOU GU¹, CHUILIN LAI¹, XIAO GUAN¹, JING ZHU², TIAN ZHAN¹, JIANPING ZHANG^1,*

BIOCELL, Vol.48, No.2, pp. 253-269, 2024, DOI:10.32604/biocell.2023.028336

Abstract Objectives: Colorectal cancer (CRC) is a serious threat to human health worldwide. Oxaliplatin is a platinum analog and is widely used to treat CRC. However, resistance to oxaliplatin restricts its effectiveness and application while its target recognition and mechanism of action also remain unclear. Therefore, we aimed to develop an oxaliplatin-resistant prognostic model to clarify these aspects. Methods: We first obtained oxaliplatin-resistant and parental cell lines, and identified oxaliplatin-resistant genes using RNA sequencing (RNA-seq) and differential gene analysis. We then acquired relevant data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Cox regression and Least Absolute… More > Graphic Abstract

Sangeeta Yadav¹, Preeti Gulia^1,*, Nasib Singh Gill^1,*, Piyush Kumar Shukla², Arfat Ahmad Khan³, Sultan Alharby⁴, Ahmed Alhussen⁴, Mohd Anul Haq⁵

CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 1253-1274, 2024, DOI:10.32604/cmc.2023.042869

Abstract Inpatient falls from beds in hospitals are a common problem. Such falls may result in severe injuries. This problem can be addressed by continuous monitoring of patients using cameras. Recent advancements in deep learning-based video analytics have made this task of fall detection more effective and efficient. Along with fall detection, monitoring of different activities of the patients is also of significant concern to assess the improvement in their health. High computation-intensive models are required to monitor every action of the patient precisely. This requirement limits the applicability of such networks. Hence, to keep the model lightweight, the already designed… More >

Dian Kesumarini^1,2, Yunita Widyastuti³, Cindy Elfira Boom¹, Lucia Kris Dinarti^4,*

Congenital Heart Disease, Vol.18, No.6, pp. 671-678, 2023, DOI:10.32604/chd.2023.044746

Abstract Tetralogy of Fallot (TOF) with total anomalous pulmonary vein connections (TAPVC) is a rare type of complex congenital heart disease among all TOF cases. Co-presentation of major aortopulmonary collateral arteries (MAPCAs) compensates for the lack of central pulmonary blood flow and decreases the severity of right-to-left shunting in TOF. We present a case of a 2-year-old child with complex diagnoses of TOF, TAPVC, a large secundum atrial septal defect (ASD), and intraoperatively identified MAPCAs. She underwent surgery to repair the TAPVC, valve-sparing reconstruction of the right ventricular outflow tract, interventricular defect closure, and the creation of patent foramen ovale (PFO).… More >

Gustavo Foronda^1,2, Vanessa Ferreira Amorim de Melo^2,3,*, Claudia Regina Pinheiro de Castro Grau⁴, Ingrid Magatti Piva¹, Glaucia Maria Penha Tavares⁴, Ana Cristina Sayuri Tanaka¹, Nana Miura¹

Congenital Heart Disease, Vol.18, No.6, pp. 649-656, 2023, DOI:10.32604/chd.2023.027987

Abstract Background: Children with congenital heart disease (CHD), even after surgical approaches, and especially those who undergo staged procedures in the first months of life, remain vulnerable to readmissions and complications, requiring very close monitoring and differentiated intervention strategies. Methods: Descriptive and exploratory study, of the experience report type, which presents the process of building the high-risk outpatient clinic for complex congenital heart diseases (AAR) at the Instituto do Coração (InCor). Results: Report of the path taken to structure the AAR, demonstrating the organization, interface with the multidisciplinary team, admission and discharge criteria, training, and patient profile. In these five years… More >

Maha Ouazzani^1,2,*, Zineb El Khammar², Nawal Oubelkacem², Youssef Aboussaleh¹, Hajar Masrour², Moncef Maiouak³, Rhizlane Berrady²

Psycho-Oncologie, Vol.17, No.4, pp. 235-244, 2023, DOI:10.32604/po.2023.044831

Abstract Introduction : la qualité de vie des patients suivis pour une hémopathie maligne dépend non seulement du type de la maladie, de ses caractéristiques cliniques, biologiques et thérapeutiques, mais aussi de la santé mentale du patient. L’objectif de notre étude est d’évaluer l’état psychologique des patients au diagnostic, de rechercher les facteurs associés à son altération et de préciser son impact sur la qualité de vie des patients. Méthode : nous avons mené une étude monocentrique transversale qui évalue la dépression, l’anxiété et la qualité de vie d’une population de patients atteints de syndromes lymphoprolifératifs sur une période de 22mois.… More >

Yiteng Zang¹, Biyun Xu², Sizhen Chen¹, Grace Mutale¹, Qiuyun Cao^3,*, Bingwei Chen^1,*

International Journal of Mental Health Promotion, Vol.25, No.12, pp. 1287-1302, 2023, DOI:10.32604/ijmhp.2023.042584

Abstract Psychosis has increasingly become a social problem, emphasizing the need to understand the relationship between mental disorders and personality. This study aimed to investigate the relationship between mental disorders and personality among psychiatric outpatients based on real-world data. Symptom Checklist 90 (SCL-90) and Eysenck Personality Questionnaire (EPQ) were used to evaluate the personality and psychopathological symptoms of patients (n = 8409) in the Psychiatric Outpatient Department at Nanjing Drum Tower Hospital. t-test was used to compare scores between patients and national norms. Pearson’s correlation coefficient and path analysis were used to explore the relationship between mental health status and personality.… More >

Yan Huang^1,*, Xiaoye Liao², Fen Cai³

International Journal of Mental Health Promotion, Vol.25, No.12, pp. 1313-1321, 2023, DOI:10.32604/ijmhp.2023.030558

Abstract Background: Elderly people with depression require special care and attention. However, nostalgia is a complex emotional situation for a person who recalls the missing past. To improve mental health, quality of life, and attitudes toward aging in institutional care, group nostalgia therapy can be a nursing intermediary for the elderly. This study aimed to analyze the effect of group nostalgia therapy on quality of life cognitive function in elderly patients with depression. Methods: A total of 89 participants were enrolled in this study, which was further categorized into a control (n = 40) and a nostalgia therapy group (n =… More >

MINJI PARK¹, CHULHWAN BANG², WON-SOO YUN³, YUN-MI JEONG^3,*

Oncology Research, Vol.32, No.2, pp. 273-282, 2024, DOI:10.32604/or.2023.044362

Abstract Fucoidan, a sulfate polysaccharide obtained from brown seaweed, has various bioactive properties, including anti-inflammatory, anti-cancer, anti-viral, anti-oxidant, anti-coagulant, anti-thrombotic, anti-angiogenic, and anti-Helicobacter pylori properties. However, the effects of low-molecular-weight fucoidan (LMW-F) on melanoma cell lines and three dimensional (3D) cell culture models are not well understood. This study aimed to investigate the effects of LMW-F on A375 human melanoma cells and cryopreserved biospecimens derived from patients with advanced melanoma. Ultrasonic wave was used to fragment fucoidan derived from Fucus vesiculosus into smaller LMW-F. MTT and live/dead assays showed that LMW-F inhibited cell proliferation in both A375 cells and patient-derived melanoma… More >