Valérie Berger^1,2,*, Hélène Hoarau^1,2, Florence Saillour^3,4

Psycho-Oncologie, Vol.17, No.3, pp. 159-166, 2023, DOI:10.32604/po.2023.044727

Abstract Le développement des plateformes numériques dans le domaine de la santé transforme les interactions soignants-soignés et la diffusion des savoirs. S’informer par le biais d’internet est devenu une habitude pour de nombreux patients et doit être pris en compte par les soignants. Ainsi, comprendre les usages des outils numériques par les patients est un enjeu de santé publique. L’étude Sav-AQ vise à comprendre les usages par des femmes atteintes d’un cancer du sein et le rôle des professionnels de santé. Il s’agit d’une étude mixte de faisabilité exploratoire, de type avant-après l’intégration dans le parcours de soins du portail «… More >

SUNG HEE LIM^1,#, HEE JIN CHO^1,2,3,#, KYOUNG-MEE KIM⁴, HO YEONG LIM¹, WON KI KANG¹, JEEYUN LEE¹, YOUNG SUK PARK¹, HEE CHEOL KIM^5,*, SEUNG TAE KIM^1,*

Oncology Research, Vol.31, No.6, pp. 855-866, 2023, DOI:10.32604/or.2023.030374

Abstract Background: Although bevacizumab is an important treatment for metastatic colorectal cancer (CRC), not all patients with CRC benefit from it; in unselected patient populations, only modest survival benefits have been reported. Methods: We evaluated clinical outcomes in 110 patients using comprehensive molecular characterization to identify biomarkers for a response to bevacizumab-containing treatment. The molecular analysis comprised whole-exome sequencing, ribonucleic acid sequencing, and a methylation array on patient tissues. Results: Genomic and molecular characterization was successfully conducted in 103 patients. Six of 103 CRC samples were hypermutated, and none of the non-hypermutant tumors were microsatellite unstable. Among those 103 patients, 89… More >

Xingbang Li^1,#, Xuan Zheng^2,#, Bowen Jin¹, Yunyan Li¹, Yongyu Shao¹, Xiaoxian Deng¹, Dingyang Li¹, Shanshan Li¹, Hongmei Zhou¹, Jie Zhang³, Xianya Zhang⁴, Qunshan Shen¹, Gangcheng Zhang^2,*

Congenital Heart Disease, Vol.18, No.4, pp. 489-489, 2023, DOI:10.32604/chd.2023.031413

Abstract This article has no abstract. More >

Shota Kawai¹, Takashi Kido^1,*, Yuta Teguri¹, Koji Miwa¹, Tomomitsu Kanaya¹, Yoichiro Ishii², Hisaaki Aoki², Futoshi Kayatani², Sanae Tsumura¹

Congenital Heart Disease, Vol.18, No.4, pp. 399-411, 2023, DOI:10.32604/chd.2023.042243

Abstract Objectives: We sought to determine the long-term outcomes and mortality-associated factors after systemic-to-pulmonary artery shunt (SPS) in patients with heterotaxy syndrome. Methods: We retrospectively analyzed all patients with a functional single ventricle and heterotaxy syndrome who underwent SPS at our center from January 2001 to April 2022. Results: This study involved 84 patients. Restrictive pulmonary blood flow requiring early modulation was presented in 34 (40%) patients. Compared with patients without restrictive pulmonary blood flow (N = 50 [60%]), the postnatal survival of these 34 patients was significantly lower at 10 years (log rank: p = 0.04), but the statistical significance… More >

Nerejda Shehu^1,*, Christian Meierhofer¹, Anja Hennemuth^2,3, Markus Hüllebrand^2,3, Pavlo Yevtushenko³, Peter Ewert¹, Stefan Martinoff⁴, Heiko Stern¹

Congenital Heart Disease, Vol.18, No.4, pp. 461-474, 2023, DOI:10.32604/chd.2023.031075

Abstract Background: Pressure measurement in total cavopulmonary connection (TCPC) patients is a domain of cardiac catheterization. 4D velocity encoded cardiovascular magnetic resonance (4D–flow MRI) offers an alternative for assessment of even minor pressure differences. The scope of this study was to measure even minor pressure differences in the anastomosis of TCPC patients, who are clinically uncompromised. Methods: Twenty-four patients (median 15 years [8;34]) with TCPC were studied prospectively by 4D-flow MRI. Pressure differences between superior vena cava (SVC) and extracardiac conduit (C) to both right pulmonary artery (RPA) and left pulmonary artery (LPA) were assessed. Small fluid obstructions as vortices within… More > Graphic Abstract

Yuki Kawasaki^1,*, Takeshi Sasaki¹, Daisuke Kobayashi²

Congenital Heart Disease, Vol.18, No.4, pp. 431-445, 2023, DOI:10.32604/chd.2023.030910

Abstract Background: Elevated Fontan pressure (FP) alone cannot fully predict clinical outcomes. We hypothesized that hemodynamic profiling using a cardiac index (CI)-systemic vascular resistance (SVR) plot could characterize clinical features and predict the prognosis of post-Fontan patients. Methods: We included post-Fontan patients who underwent cardiac catheterization at age < 10 years. Patients were classified into four categories: A, CI  ≥ 3, SVR index (SVRI) ≥ 20; B, CI < 3, SVRI ≥ 20; C, CI ≥ 3, SVRI < 20; and D, CI < 3, SVRI < 20. The primary outcome was freedom from the combined endpoint: new onset of protein-losing enteropathy or plastic bronchitis, heart transplant, and death. Clinical and hemodynamic variables and freedom from… More > Graphic Abstract

Dongyun Bie^1,#, Hongbai Wang^1,#, Chaobin Zhang², Chunrong Wang³, Yuan Jia¹, Su Yuan¹, Sheng Shi¹, Jiangshan Huang¹, Jianhui Wang^1,*, Fuxia Yan^1,*

Congenital Heart Disease, Vol.18, No.4, pp. 475-488, 2023, DOI:10.32604/chd.2023.028017

Abstract Purpose: This study sought to explore the effect of intraoperative mean blood glucose levels and variability on postoperative acute kidney injury (AKI) in children undergoing congenital cardiac surgery. Methods: We conducted a prospective nested case-control study in children (age < 18 years) undergoing congenital heart surgery with cardiopulmonary bypass (CPB) at the Fuwai Hospital between April 01, 2022 and July 30, 2022. Cases were individuals who developed AKI within the first postoperative 7 days (AKI group) and controls were those without AKI (Non-AKI group) according to KDIGO criteria. AKI and Non-AKI groups unmatched and 1:1 matched by age, sex, and baseline serum… More > Graphic Abstract

Omar Reyad^1,2, Hazem Ibrahim Shehata^1,3, Mohamed Esmail Karar^1,4,*

CMC-Computers, Materials & Continua, Vol.76, No.2, pp. 1689-1700, 2023, DOI:10.32604/cmc.2023.039084

Abstract Falling is among the most harmful events older adults may encounter. With the continuous growth of the aging population in many societies, developing effective fall detection mechanisms empowered by machine learning technologies and easily integrable with existing healthcare systems becomes essential. This paper presents a new healthcare Internet of Health Things (IoHT) architecture built around an ensemble machine learning-based fall detection system (FDS) for older people. Compared to deep neural networks, the ensemble multi-stage random forest model allows the extraction of an optimal subset of fall detection features with minimal hyperparameters. The number of cascaded random forest stages is automatically… More >

F. Farsi, E. Huyghe, L. Vanlemmens, S. Dolbeault, T. Almont, E. Marx, I. Flandrin, J. Véronique-Baudin, B. Panes-Ruedin, P. Bondil

Psycho-Oncologie, Vol.17, No.2, pp. 99-104, 2023, DOI:10.3166/pson-2022-0235

Abstract L’abord systématisé et en routine de la préservation de la vie intime, de la sexualité et de la fertilité n’est pas encore pleinement intégré à la consultation des praticiens et pas de manière significative par les autres intervenants du parcours de soins en cancérologie. On sait pourtant, et de manière de plus en plus documentée, que ce sont des sujets de préoccupation pour les patients et leurs partenaires, qui considèrent, pour leur grande majorité, que leur santé sexuelle et/ou leurs projets parentaux sont des sujets importants. Depuis maintenant plus de dix ans, un groupe d’experts nationaux (GEX–Groupe d’experts oncosexualité/oncofertilité de… More >

M. Cuniah, G. Bréchon, N. Bailly

Psycho-Oncologie, Vol.17, No.2, pp. 71-78, 2023, DOI:10.3166/pson-2022-0232

Abstract La composante spirituelle caractérise l’un des socles majeurs sur lesquels repose la pratique des soins palliatifs. Or, dans le contexte français, cette composante reste peu explorée du point de vue des patients. Cette étude a pour objectif d’explorer la dimension spirituelle et la place de l’accompagnement spirituel chez des patients dans le cadre d’une maladie incurable. À cette fin, des entretiens semidirectifs ont été menés auprès de 10 patients en soins palliatifs. Une analyse de contenu thématique a été réalisée. Les résultats montrent que la spiritualité est une question complexe, généralement définie comme une recherche de sens. Les besoins spirituels… More >