Home / Advanced Search

  • Title/Keywords

  • Author/Affliations

  • Journal

  • Article Type

  • Start Year

  • End Year

Update SearchingClear
  • Articles
  • Online
Search Results (8)
  • Open Access


    A Randomized Controlled Open-Label Pilot Study of Simvastatin Addition to Whole-Brain Radiation Therapy in Patients With Brain Metastases

    Manal El-Hamamsy*, Hesham Elwakil, Amr S. Saad, May A. Shawki*

    Oncology Research, Vol.24, No.6, pp. 521-528, 2016, DOI:10.3727/096504016X14719078133528

    Abstract Statins have been reported to have a potential radiosensitizing effect that has not been evaluated in clinical trials. The aim of this study was to evaluate the efficacy and safety of simvastatin in addition to whole-brain radiation therapy (WBRT) in patients with brain metastases (BM). A prospective randomized, controlled, open-label pilot study was conducted on 50 Egyptian patients with BM who were randomly assigned to receive 30-Gy WBRT (control group: 25 patients) or 30 Gy WBRT+ simvastatin 80 mg/day for the WBRT period (simvastatin group: 25 patients). The primary outcome was radiological response at 4… More >

  • Open Access


    How Fast Can Nurses Learn Therapeutic Communication Skills? A Pilot Study on Brief Hypnotic Communication Training Conducted with Oncology Nurses

    H. Zarglayoun, C. Arbour, J. Delage, S. Pierre, M. Tremblay, D. Hjeij, P. Rainville, D. Ogez

    Psycho-Oncologie, Vol.16, No.4, pp. 375-379, 2022, DOI:10.3166/pson-2022-0202

    Abstract Objective: This project aimed to train nurses on an oncology unit in hypnotic communication to reduce treatment-related pain and anxiety in their patients. A pilot study was conducted to assess changes in hypnotic communication behaviors associated with the training.
    Methods: Nurses were recruited and their interactions during a simulated patient admission for treatment (before and after training) were recorded. Hypnotic communication skills were assessed by independent reviewers using a training checklist listing different hypnotic communication techniques and a validated assessment scale (Sainte-Justine Hypnotic Communication Assessment Scale, SJ-HCAS).
    Results: Seven nurses were evaluated. Wilcoxon pairedsample tests (pre–post) reported significant More >

  • Open Access


    Lower Limb Muscle Forces in Table Tennis Footwork during Topspin Forehand Stroke Based on the OpenSim Musculoskeletal Model: A Pilot Study

    Yuqi He1,2,3, Shirui Shao1, Gusztáv Fekete3, Xiaoyi Yang1, Xuanzhen Cen1,4, Yang Song1,4, Dong Sun1,*, Yaodong Gu1,*

    Molecular & Cellular Biomechanics, Vol.19, No.4, pp. 221-235, 2022, DOI:10.32604/mcb.2022.027285

    Abstract Introduction: Footwork is one of the training contents that table tennis players and coaches focus on. This study aimed to gain a thorough understanding of the muscle activity of the table tennis footwork and creating a musculoskeletal model to investigate the muscle forces, joint kinematic, and joint kinetic characteristics of the footwork during topspin forehand stroke. Methods: Six male table tennis athletes (height: 171.98 ± 4.97 cm; weight: 68.77 ± 7.86 kg; experience: 10.67 ± 1.86 years; age: 22.50 ± 1.64 years) performed chasse step and one-step footwork to return the ball from the coach by… More >

  • Open Access


    A Pilot Study of Silymarin as Supplementation to Reduce Toxicities in Metastatic Colorectal Cancer Patients Treated With First-Line FOLFIRI Plus Bevacizumab

    Tsung-Kun Chang*†, Tzu-Chieh Yin‡§, Wei-Chih Su*†, Hsiang-Lin Tsai, Ching-Wen Huang, Yen-Cheng Chen*, Ching-Chun Li*, Po-Jung Chen*, Cheng-Jen Ma, Kuo-Hsiang Chuang#, Tian-Lu Cheng**, Jaw-Yuan Wang*†¶††‡‡§§

    Oncology Research, Vol.28, No.7-8, pp. 801-809, 2020, DOI:10.3727/096504021X16218531628569

    Abstract Irinotecan, a topoisomerase inhibitor, is a common cytotoxic agent prescribed for metastatic colorectal cancer (mCRC) patients. Diarrhea is the most common adverse event (AE). The underlying mechanism of irinotecaninduced diarrhea is intestinal mucosal damage caused by SN-38 (active metabolite of irinotecan) hydrolyzed from SN-38G (inactive metabolite) by bacterial -glucuronidase ( G). According to an animal study, silymarin reduces the activity of bacterial G without impairing antitumor efficacy. We conducted a prospective openlabel pilot study to evaluate the effect of silymarin as supplementation in reducing toxicities of mCRC patients undergoing irinotecan-based chemotherapy. We enrolled and randomized More >

  • Open Access


    Managing Traumatic Stress Using a Mental Health Care Mobile App: A Pilot Study

    Yun-Jung Choi1,#, Eun-jung Ko2,#, Eun-Joo Choi2,*, Youn-Joo Um2,*

    International Journal of Mental Health Promotion, Vol.23, No.3, pp. 385-393, 2021, DOI:10.32604/IJMHP.2021.015018

    Abstract This study aims to contribute to improving mental health services and establishing a direction for disaster survivors by verifying the effectiveness of the TLS (Training for Life Skills) app, a mental health management mobile application. Altogether, 22 disaster survivors received access to the app (with guidance) for eight weeks; we analyzed its effectiveness by examining each participant’s electroencephalography data, which were collected while they were utilizing the app. The results of this study show that the use of the TLS app had a significant positive effect on emotional quotient, basic rhythm quotient (left brain, right More >

  • Open Access


    Screening Coarctation of Aorta with Clinical and Echocardiographic Profiles in Infants: A Pilot Study

    Ruikun Zou1, Yifei Wang1,*, Chengcheng Pang2, Yunxia Sun1, Chen Chen1, Jian Zhuang3

    Congenital Heart Disease, Vol.16, No.2, pp. 159-170, 2021, DOI:10.32604/CHD.2021.015050

    Abstract Aim: To determine the profiles of clinical features including four-limb blood pressure (BP), saturations of peripheral oxygen (SpO2), and echocardiographic features in infants with coarctation of aorta (CoA) to facilitate congenital heart diseases screening. Methods: The charts of infants with CoA were retrospectively reviewed. All in-hospital infants suspected of congenital heart diseases by clinical teams were prospectively measured of four limbs BPs and SpO2 in a regional cardiac transferring center during 2013 and 2019. Echocardiography as a gold standard test was followed within 2 days after suspicion. All infants were divided into non-significant CoA group or significant… More >

  • Open Access


    A Knowledge-Based Pilot Study on Assessing the Music Influence

    Sabin C. Buraga1, Octavian Dospinescu2,*

    CMC-Computers, Materials & Continua, Vol.66, No.3, pp. 2857-2873, 2021, DOI:10.32604/cmc.2021.014429

    Abstract A knowledge-driven approach is proposed for assessing the music influence on university students. The proposed method of modeling and conducting the interactive pilot study can be useful to convey other surveys, interviews, and experiments created in various phases of the user interface (UI) design processes, as part of a general human-computer interaction (HCI) methodology. Benefiting from existing semantic Web and linked data standards, best practices, and tools, a microservice-oriented system is developed as a testbed platform able to generate playlists in a smart way according to users’ music preferences. This novel approach could bring also More >

  • Open Access


    Quality of life and sexual well-being in patients with a Fontan circulation: An explorative pilot study with a mixed method design

    Djoeke Wolff1, Henricus B. M. van de Wiel2, Mirthe E. de Muinck Keizer1, Joost P. van Melle3, Petronella G. Pieper3, Rolf M. F. Berger1, Tjark Ebels4, Willebrord C. M. Weijmar Schultz5

    Congenital Heart Disease, Vol.13, No.2, pp. 319-326, 2018, DOI:10.1111/chd.12576

    Abstract Objective: To get an impression of the quality of life (QOL) and sexual well-being in the Fontan population, and to generate hypotheses for future research.
    Methods: For this cross-sectional pilot study, questionnaires regarding health-related QOL, sexual function and fertility/pregnancy were completed by 21 patients with a Fontan circulation >16 years old, followed at the University Medical Center Groningen, the Netherlands. Semi-structured qualitative interviews were conducted in 8 patients.
    Results: Fontan patients scored significantly lower on general health than their healthy peers (t (19)=-3.0, P = .008), whereas their scores on other QOL domains and sexual well-being were comparable… More >

Displaying 1-10 on page 1 of 8. Per Page