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  • Open Access

    ARTICLE

    BET protein inhibitor apabetalone represses Porphyromonas gingivalis LPS-induced macrophage M1 polarization via regulating miR-130a/STAT3 axis

    MEIHUA CHEN1,2, HUIHUI WANG3, XIAOFENG CHEN1,2, YAN CHEN1,2, TIANYING BIAN1,2,*

    BIOCELL, Vol.46, No.10, pp. 2281-2289, 2022, DOI:10.32604/biocell.2022.020697 - 13 June 2022

    Abstract Periodontitis is a frequent chronic inflammatory disorder destroying periodontium. Recent studies have revealed the role of bromodomain and extraterminal domain inhibitor (BETi) and microRNA (miR)-130a in regulating macrophage polarization and pro-inflammatory response. However, little is known about whether apabetalone (a novel BETi) and miR-130a are correlated with chronic inflammatory state in periodontitis by regulating macrophage polarization. Here murine RAW264.7 macrophages were applied as an in vitro inflammatory model. After treatment with Porphyromonas gingivalis-derived lipopolysaccharide (Pg LPS) and apabetalone, the expression of macrophage M1 polarization markers and inflammatory cytokines was assessed using real-time PCR, western blot, and enzyme-linked… More >

  • Open Access

    ARTICLE

    Motor Torque Measurement Using Dual-Function Radar Polarized Signals of Flux

    B. Chinthamani1,*, N. S. Bhuvaneswari2, R. Senthil Kumar3, N. R. Shanker4

    Intelligent Automation & Soft Computing, Vol.34, No.1, pp. 515-530, 2022, DOI:10.32604/iasc.2022.025410 - 15 April 2022

    Abstract Motor Torque (MT) measurement plays a vital role for evaluating the performance of squirrel cage induction motor during operating conditions. Accurate and continuous measurements of MT provide information regarding driving load capacity, performance degradation of motor, reduces downtime and increases the efficiency. Traditional inline torque sensors-based measurement becomes inaccurate during abrupt change in load during starting condition of motor due to torque spikes. Mounting of torque sensor on motor is a major problem during torque measurement. Improper mounting of sensor acquires signals from other inefficient driveline components such as gearbox, couplings, and bearing. In this… More >

  • Open Access

    ARTICLE

    5G Antenna Gain Enhancement Using a Novel Metasurface

    Mubashir Ashfaq1, Shahid Bashir1,*, Syed Imran Hussain Shah2, Nisar Ahmad Abbasi3, Hatem Rmili4,5, Muhammad Abbas Khan6

    CMC-Computers, Materials & Continua, Vol.72, No.2, pp. 3601-3611, 2022, DOI:10.32604/cmc.2022.025558 - 29 March 2022

    Abstract This article presents a Sub-6 GHz microstrip patch antenna (MPA) with enhanced gain using metamaterial (MTM) superstrate. The source MPA operates at 4.8 GHz and has a peak gain of 5.3 dBi at the resonance frequency. A window-shaped unit cell is designed and investigated through the material wave propagation technique. The unit cell shows an Epsilon Near Zero (ENZ)-Mu Very Large (MVL) behavior around 4.8 GHz. The unit cell has a fourfold geometry which makes it a polarization independent metamaterial. A double layer antenna is designed by placing a 4 × 4 MTM slab as a superstrate More >

  • Open Access

    ARTICLE

    miRNA-148b-3p targeting SOCS3 inhibits macrophage M2 polarization by JAK2/STAT3 pathway in immune thrombocytopenia

    YANG YANG, LIJUAN FU, CHUNMEI CHEN, MEIWEI HU

    BIOCELL, Vol.46, No.5, pp. 1319-1328, 2022, DOI:10.32604/biocell.2022.015760 - 06 January 2022

    Abstract Aberrant expression of miRNAs is significantly correlated with the occurrence of immune thrombocytopenic purpura (ITP). The immune imbalance of M1/M2 macrophage contributes to the development of ITP. However, the role of miR-148b-3p in macrophage phenotype imbalance remains unknown in ITP. In this study, we aimed to explore whether miR-148b-3p inhibits M2 macrophage polarization in ITP and to investigate the underlying mechanism. Peripheral blood from 22 ITP patients were collected, and real-time PCR confirmed that miR-148b-3p was up-regulated and Western blot analyses detected the expression of SOCS3 was down-regulated. Subsequent dual-luciferase reporter gene assay indicated that More >

  • Open Access

    ARTICLE

    Polarization Insensitive Broadband Zero Indexed Nano-Meta Absorber for Optical Region Applications

    Ismail Hossain1, Md Samsuzzaman2, Ahasanul Hoque3, Mohd Hafiz Baharuddin3, Norsuzlin Binti Mohd Sahar1, Mohammad Tariqul Islam3,*

    CMC-Computers, Materials & Continua, Vol.71, No.1, pp. 993-1009, 2022, DOI:10.32604/cmc.2022.021435 - 03 November 2021

    Abstract Broadband response metamaterial absorber (MMA) remains a challenge among researchers. A nanostructured new zero-indexed metamaterial (ZIM) absorber is presented in this study, constructed with a hexagonal shape resonator for optical region applications. The design consists of a resonator and dielectric layers made with tungsten and quartz (Fused). The proposed absorbent exhibits average absorption of more than 0.8972 (89.72%) within the visible wavelength of 450–600 nm and nearly perfect absorption of 0.99 (99%) at 461.61 nm. Based on computational analysis, the proposed absorber can be characterized as ZIM. The developments of ZIM absorbers have demonstrated plasmonic… More >

  • Open Access

    ARTICLE

    Ultra-wideband Frequency Selective Surface for Communication Applications

    Shahid Habib1, Ghaffer Iqbal Kiani2, Muhammad Fasih Uddin Butt1,3,*, Syed Muzahir Abbas4,5, Abdulah Jeza Aljohani2, Soon Xin Ng3

    CMC-Computers, Materials & Continua, Vol.70, No.3, pp. 6177-6187, 2022, DOI:10.32604/cmc.2022.021644 - 11 October 2021

    Abstract A low-profile ultra-wideband (UWB) band-stop frequency selective surface (FSS) is designed for S-, C-, X- and Ku-bands communication applications. The FSS is constructed by using square and circular loop elements printed on the top and bottom sides of the RO3210 substrate. The FSS has been designed to reduce the electromagnetic interference (EMI) as well as to mitigate the harmful effects of electromagnetic radiation on the human body caused by different radio devices. The dimension and size of the UWB FSS have been reduced to 0.12 λ × 0.12 λ and 90%, respectively, as compared to More >

  • Open Access

    ARTICLE

    An AMC-Based Circularly Polarized Antenna for 5G sub-6 GHz Communications

    Hussain Askari, Niamat Hussain, Domin Choi, Md. Abu Sufian, Anees Abbas, Nam Kim*

    CMC-Computers, Materials & Continua, Vol.69, No.3, pp. 2997-3013, 2021, DOI:10.32604/cmc.2021.018855 - 24 August 2021

    Abstract This paper presents an AMC (artificial magnetic conductor)-based wideband circularly polarized printed monopole antenna for unidirectional radiation. The antenna includes an AMC reflector, a coplanar waveguide (CPW) feed structure to excite the antenna, a ground plane with a rectangular slot on the left side of feedline, and an asymmetrical ground plane on its right side. The induced surface currents on CWP feedline, rectangularly slotted, and asymmetrical ground planes cause circularly polarized radiations. The AMC reflector consisting periodic metallic square patches is used instead of the conventional PEC (perfect electric conductor) reflector, the distance between the More >

  • Open Access

    ARTICLE

    Single-Layer Wideband Circularly Polarized Antenna Using Non-Uniform Metasurface for C-band Applications

    Huy Hung Tran1,2, Khoa Nguyen-Dang1,2,*, Niamat Hussain3

    CMC-Computers, Materials & Continua, Vol.68, No.2, pp. 2487-2498, 2021, DOI:10.32604/cmc.2021.016027 - 13 April 2021

    Abstract A single-layer design of non-uniform metasurface (MS) based circularly polarized (CP) antenna with wideband operation characteristic is proposed and investigated in this paper. The antenna is excited by a truncated corner squared patch as a primary radiating CP source. Then, a non-uniform MS is placed in the same layer with the driven patch. Besides increasing the impedance bandwidth, the non-uniform MS also generates two additional CP bands in the high frequency band, leading to significantly increase the antenna’s overall performances. The use of non-uniform MS distinguishes our design from the other CP MS based antennas… More >

  • Open Access

    ARTICLE

    Interpretation of the Entangled States

    D. L. Khokhlov*

    Journal of Quantum Computing, Vol.2, No.3, pp. 147-150, 2020, DOI:10.32604/jqc.2020.014734 - 31 December 2020

    Abstract An interpretation of the entangled states is considered. Two-photon states of photon A on path a and photon B on path b with polarizations H, V are constructed. Two synchronized photons, 1 and 2, can take the paths a and b, with equal probability 50%. In the bases a, b and H, V, the states of the photons form the product states. In the basis 1, 2, the states of the photons form the entangled state. The states of the photons in the bases 1, 2; a, b; H, V are inseparable. The correlation of the photons due to the entanglement in the More >

  • Open Access

    ARTICLE

    Exosomes derived from circBCRC-3-knockdown mesenchymal stem cells promoted macrophage polarization

    QI SONG1, JUN ZHANG1, QIANG ZHANG1, JING LIU1, KE LV1, JIALU YAO1,2,3,*, YAFENG ZHOU2,3,*

    BIOCELL, Vol.44, No.4, pp. 623-629, 2020, DOI:10.32604/biocell.2020.012645 - 24 December 2020

    Abstract Macrophages play an essential role in the myocardial ischemia-reperfusion injury (MIRI), and the macrophage shifting from M1 to M2 phenotypes might be a potential strategy for the treatment of MIRI. It has been reported that miR-182 plays an important role in MSC-Exo-associated macrophage polarization. As circBCRC-3 is a newly discovered circle RNA that worked as a sponge of miR-182, this research aimed to find if circBCRC-3 plays a role in MSC-Exo-associated macrophage polarization. Firstly, circBCRC-3 was identified by divergent primers in mesenchymal stem cells (MSCs). Secondly, the exosome of MSCs was isolated and identified by More >

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