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  • Open Access


    Application of exosomal miRNA mediated macrophage polarization in colorectal cancer: Current progress and challenges


    Oncology Research, Vol.32, No.1, pp. 61-71, 2024, DOI:10.32604/or.2023.043481

    Abstract Colorectal cancer (CRC) is a major global health problem with high morbidity and mortality rates. Surgical resection is the main treatment for early-stage CRC, but detecting it early is challenging. Therefore, effective therapeutic targets for advanced patients are still lacking. Exosomes, tiny vesicles in body fluids, play a crucial role in tumor metastasis, immune regulation, and drug resistance. Interestingly, they can even serve as a biomarker for cancer diagnosis and prognosis. Studies have shown that exosomes can carry miRNA, mediate the polarization of M1/M2 macrophages, promote the proliferation and metastasis of cancer cells, and affect the prognosis of CRC. Since… More > Graphic Abstract

    Application of exosomal miRNA mediated macrophage polarization in colorectal cancer: Current progress and challenges

  • Open Access


    Phase Field Modeling of Coupling Evolution of Polarization, Fracture and Dielectric Breakdown in Ferroelectric Materials

    Yong Zhang1,*, Jie Wang2,3

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.1, pp. 1-1, 2023, DOI:10.32604/icces.2023.09368

    Abstract Ferroelectric materials have been widely used in various electromechanical devices such as sensors, actuators, transducers and energy storage devices due to their distinguished electromechanical coupling properties. Ferroelectric materials usually bear large mechanical loads and high electric fields in order to give full play to their potential. The interaction between fracture and dielectric breakdown is able to occur since the filler inside a crack will change the dielectric behaviors around it and dielectric breakdown can change the local mechanical properties of dielectric materials because of its weakening of chemical bonds. Therefore, a comprehensive and in-depth understanding of the fracture and dielectric… More >

  • Open Access


    Royal Crown Shaped Polarization Insensitive Perfect Metamaterial Absorber for C-, X-, and Ku-Band Applications

    Md. Salah Uddin Afsar1, Mohammad Rashed Iqbal Faruque1,*, Sabirin Abdullah1, Mohammad Tariqul Islam2

    CMC-Computers, Materials & Continua, Vol.76, No.1, pp. 455-469, 2023, DOI:10.32604/cmc.2023.036655

    Abstract This study proposed a new royal crown-shaped polarisation insensitive double negative triple band microwave range electromagnetic metamaterial absorber (MA). The primary purpose of this study is to utilise the exotic characteristics of this perfect metamaterial absorber (PMA) for microwave wireless communications. The fundamental unit cell of the proposed MA consists of two pentagonal-shaped resonators and two inverse C-shaped metallic components surrounded by a split ring resonator (SRR). The bottom thin copper deposit and upper metallic resonator surface are disjoined by an FR-4 dielectric substrate with 1.6 mm thickness. The CST MW studio, a high-frequency electromagnetic simulator has been deployed for… More >

  • Open Access


    A Th2-score in the tumor microenvironment as a predictive biomarker of response to Bacillus Calmette Guérin in patients with non-muscle invasive bladder carcinoma: A retrospective study


    Oncology Research, Vol.31, No.2, pp. 207-220, 2023, DOI:10.32604/or.2023.028163

    Abstract Intravesical Bacillus Calmette Guerin (BCG) is the gold standard therapy for intermediate/high-risk nonmuscle invasive bladder cancer (NMIBC). However, the response rate is ~60%, and 50% of non-responders will progress to muscle-invasive disease. BCG induces massive local infiltration of inflammatory cells (Th1) and ultimately cytotoxic tumor elimination. We searched for predictive biomarker of BCG response by analyzing tumor-infiltrating lymphocyte (TIL) polarization in the tumor microenvironment (TME) in pre-treatment biopsies. Pre-treatment biopsies from patients with NMIBC who received adequate intravesical instillation of BCG (n = 32) were evaluated retrospectively by immunohistochemistry. TME polarization was assessed by quantifying the T-Bet+ (Th1) and GATA-3+… More > Graphic Abstract

    A Th2-score in the tumor microenvironment as a predictive biomarker of response to Bacillus Calmette Guérin in patients with non-muscle invasive bladder carcinoma: A retrospective study

  • Open Access


    Graphene-Based Active Tunable Metasurfaces for Dynamic Terahertz Absorption and Polarization Conversion

    Haoran Wei, Tian Ji, Jianqing Huang*

    Journal of Renewable Materials, Vol.11, No.2, pp. 731-743, 2023, DOI:10.32604/jrm.2022.022283

    Abstract Simultaneous broadband absorption and polarization conversion are crucial in many practical applications, especially in terahertz communications. Thus, actively tunable metamaterial systems can exploit the graphene-based nanomaterials derived from renewable resources because of the flexible surface conductivity and selective permeability of the nanomaterials at terahertz frequencies. In this paper, we propose a graphene-based active tunable bifunctional metasurface for dynamic terahertz absorption and polarization conversion. The graphene ring presents a certain opening angle (A) along the diagonal of the xoy plane. When A = 0°, the proposed metasurface behaves as a broadband absorber. Numerical results show the feasibility of achieving this polarization-insensitive… More >

  • Open Access


    Modelling of Wideband Concentric Ring Frequency Selective Surface for 5G Devices

    Ankush Kapoor1, Pradeep Kumar2,*, Ranjan Mishra3

    CMC-Computers, Materials & Continua, Vol.74, No.1, pp. 341-361, 2023, DOI:10.32604/cmc.2023.028874

    Abstract Frequency selective surfaces (FSSs) play an important role in wireless systems as these can be used as filters, in isolating the unwanted radiation, in microstrip patch antennas for improving the performance of these antennas and in other 5G applications. The analysis and design of the double concentric ring frequency selective surface (DCRFSS) is presented in this research. In the sub-6 GHz 5G FR1 spectrum, a computational synthesis technique for creating DCRFSS based spatial filters is proposed. The analytical tools presented in this study can be used to gain a better understanding of filtering processes and for constructing the spatial filters.… More >

  • Open Access


    Incidence and Related Risk Factors of Junctional Ectopic Tachycardia in Infants after Cardiac Surgery for Congenital Heart Disease

    Jae Hee Seol1,4,#, Se Yong Jung1,#, Jae Young Choi1, Han Ki Park2, Young Hwan Park2, Nam Kyun Kim1,3,*

    Congenital Heart Disease, Vol.17, No.5, pp. 569-578, 2022, DOI:10.32604/chd.2022.018436

    Abstract Objective: Junctional ectopic tachycardia is common after cardiac surgery for congenital heart disease. However, its incidence and related risk factors in infants after cardiac surgery are not well known. The objective of this study was to determine the overall incidence and related risk factors for junctional ectopic tachycardia in neonates and infants. Methods: We enrolled a total of 271 patients aged <1 year who underwent open cardiac surgery at Severance Cardiovascular Hospital from January 2018 to December 2020. Exclusion criteria were immediate postoperative mortality, other arrhythmias detected in the perioperative period, and prematurity. Result: The overall incidence of junctional ectopic… More >

  • Open Access


    Asymmetric Patch Element Reflectarray with Dual Linear and Dual Circular Polarization

    M. Hashim Dahri1, M. H. Jamaluddin2, M. Inam3, M. R. Kamarudin4, F. C. Seman4, A. Y. I. Ashyap4, Z. A. Shamsan5,*, K. Almuhanna5, F. Alorifi5

    CMC-Computers, Materials & Continua, Vol.73, No.3, pp. 6085-6101, 2022, DOI:10.32604/cmc.2022.031532

    Abstract A reflectarray antenna consisting of asymmetrical patch elements is proposed, which is capable of producing dual linear and dual circular polarized operation at 26 GHz frequency. The main purpose of this design is to support four different polarizations using the same patch element. The proposed reflectarray has a single layer configuration with a linearly polarized feed and circular ring slots in the ground plane. Asymmetric patch element is designed from a square patch element by tilting its one vertical side to some optimized inclination. A wide reflection phase range of 600° is obtained with the asymmetric patch element during unit cell… More >

  • Open Access


    BET protein inhibitor apabetalone represses Porphyromonas gingivalis LPS-induced macrophage M1 polarization via regulating miR-130a/STAT3 axis


    BIOCELL, Vol.46, No.10, pp. 2281-2289, 2022, DOI:10.32604/biocell.2022.020697

    Abstract Periodontitis is a frequent chronic inflammatory disorder destroying periodontium. Recent studies have revealed the role of bromodomain and extraterminal domain inhibitor (BETi) and microRNA (miR)-130a in regulating macrophage polarization and pro-inflammatory response. However, little is known about whether apabetalone (a novel BETi) and miR-130a are correlated with chronic inflammatory state in periodontitis by regulating macrophage polarization. Here murine RAW264.7 macrophages were applied as an in vitro inflammatory model. After treatment with Porphyromonas gingivalis-derived lipopolysaccharide (Pg LPS) and apabetalone, the expression of macrophage M1 polarization markers and inflammatory cytokines was assessed using real-time PCR, western blot, and enzyme-linked immuno sorbent assay… More >

  • Open Access


    Motor Torque Measurement Using Dual-Function Radar Polarized Signals of Flux

    B. Chinthamani1,*, N. S. Bhuvaneswari2, R. Senthil Kumar3, N. R. Shanker4

    Intelligent Automation & Soft Computing, Vol.34, No.1, pp. 515-530, 2022, DOI:10.32604/iasc.2022.025410

    Abstract Motor Torque (MT) measurement plays a vital role for evaluating the performance of squirrel cage induction motor during operating conditions. Accurate and continuous measurements of MT provide information regarding driving load capacity, performance degradation of motor, reduces downtime and increases the efficiency. Traditional inline torque sensors-based measurement becomes inaccurate during abrupt change in load during starting condition of motor due to torque spikes. Mounting of torque sensor on motor is a major problem during torque measurement. Improper mounting of sensor acquires signals from other inefficient driveline components such as gearbox, couplings, and bearing. In this paper, we propose a non-contact… More >

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