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    Study of Hepatocytes Polyploidization Peculiarities in Cholestatic Liver of Adult Rats

    Salome Kiparoidze1,*, Nino Karumidze2, Ekaterine Bakuradze1, Irina Modebadze1, Levan Rusishvili1, Dimitri Kordzaia2, Diana Dzidziguri1

    Molecular & Cellular Biomechanics, Vol.18, No.3, pp. 131-138, 2021, DOI:10.32604/mcb.2021.015596

    Abstract According to the literature, different mechanisms and kinetics proceeding of regenerative growth has been established using the basic models of liver regeneration (after resection or chemically induced). Hence, in order to determine general regularities of the adaptive-compensatory processes in various pathological conditions, the processes taking place in the cholestatic liver of adult white rats during the first four days after common bile duct ligation have been studied. It has been shown that in cholestatic liver, compensatory-adaptive processes take place with different kinetics compared to those after resection. In particular, in response to the increased functional… More >

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