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  • Open Access


    Effects of Dexmedetomidine Combined with Remifentanil Anesthesia and Propofol Combined with Remifentanil Anesthesia on Perioperative Inflammatory Response and Pulmonary Function in Patients with Lung Cancer

    Siqiang Tian1,#, Yao Jiang2,#, Ying Wang1, Jie Song1,*

    Oncologie, Vol.22, No.1, pp. 13-21, 2020, DOI:10.32604/oncologie.2020.012492

    Abstract To explore the effects of dexmedetomidine combined with remifentanil anesthesia and propofol combined with remifentanil anesthesia on perioperative inflammatory response and pulmonary function in patients with lung cancer. Totally 128 patients admitted to our hospital for lung cancer surgery were taken as the research object of this experiment. Among them, 67 cases were sedated with dexmedetomidine combined with remifentanil (Group A), and 61 cases were sedated with propofol combined with remifentanil (Group B). The changes of vital signs, respiratory interval (RR), blood oxygen saturation (SpO2) and blood sugar before and after sedation were recorded. The… More >

  • Open Access


    Chronotropic Response and Pulmonary Function are Associated with Exercise Performance in Children and Adolescents with Repaired Tetralogy of Fallot Independent of Cardiac Function

    Shivani M. Bhatt1,*, Michael L. O’Byrne2, Michael McBride2, Stephen M. Paridon2, Elizabeth Goldmuntz2, Laura Mercer-Rosa2

    Congenital Heart Disease, Vol.15, No.2, pp. 101-115, 2020, DOI:10.32604/CHD.2020.011287

    Abstract Objective: The determinants of exercise capacity in repaired tetralogy of Fallot (rTOF) are multifactorial and remain incompletely understood. This study sought to evaluate the association of chronotropic response with exercise parameters and investigate the determinants of heart rate reserve (HRR) in a cohort of children and adolescents with rTOF. Design: We retrospectively analyzed patients with rTOF, age 8–18 years, who underwent cardiac magnetic resonance (CMR) and cardiopulmonary exercise test (CPET) for research purposes. Linear regression models were performed to test associations among clinical, CMR and CPET parameters. Outcomes included percent-predicted maximum VO2 (%mVO2) and HRR. Results: A total… More >

  • Open Access


    The utility of combined cardiopulmonary exercise stress testing in the evaluation of pediatric patients with chest pain

    Soham Dasgupta1, Megan Stark2, Sonal Bhatt3, Peter Fischbach1, Shriprasad Deshpande1

    Congenital Heart Disease, Vol.13, No.6, pp. 1058-1063, 2018, DOI:10.1111/chd.12681

    Abstract Introduction: A cardiac cause is an extremely rare etiology of pediatric chest pain. Despite its low sensitivity/specificity, exercise stress testing (EST) is widely used to determine the prognosis in patients with suspected/established coronary disease. We aimed to look at the utility of a combined cardiopulmonary EST in the evaluation of pediatric patients with chest pain.
    Methods: After institutional review board approval, a retrospective chart review was performed of all pediatric patients who were referred for an EST for chest pain from January 2014 to 2017. Patients with incomplete records, severe congenital heart disease, and a prior EST… More >

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