Raquel Hidalgo-Sanz, María-Ángeles Del-Castillo-Alonso, Laura Monforte, Rafael Tomás-Las-Heras, Encarnación Núñez-Olivera, Javier Martínez-Abaigar^*

Phyton-International Journal of Experimental Botany, Vol.94, No.11, pp. 3453-3470, 2025, DOI:10.32604/phyton.2025.070087 - 01 December 2025

Abstract Grapevine (Vitis vinifera L.) is one of the main crops worldwide, and ultraviolet-B (UV-B, 280–315 nm) radiation is emerging as a promising technical tool to enhance secondary metabolites that can contribute to the quality and health-promoting properties of both grapes and the resulting wines. However, few studies have assessed the effectiveness of UV-B supplements under field conditions. Here, we compared the effects of two different field UV-B treatments (a single supplement applied at pre-harvest, and a double supplement applied at both veraison and pre-harvest) on the phenolic composition of Tempranillo grape skins and the resulting wines.… More >

Si Qin, Shu Tang, Lijiao Xie, Jianbo Zhu, Jianguo Sun^*

Oncology Research, Vol.33, No.12, pp. 4145-4154, 2025, DOI:10.32604/or.2025.068300 - 27 November 2025

Abstract Background: Primary pulmonary lymphoepithelioma-like carcinoma (PPLELC) is a rare subtype of primary non-small cell lung cancer (NSCLC), with no established treatment guidelines. We present a case of a young female with PPLELC who achieved a pathological complete response (pCR) in both primary and metastatic lesions after receiving combined immunotherapy and radiotherapy. Case description: We present a 33-year-old female patient with stage IVa (cT2bN0M1b) PPLELC. As a first-line treatment, the patient received seven cycles of nab-paclitaxel combined with toripalimab (a PD-1 inhibitor) and achieved stable disease. This was followed by toripalimab maintenance therapy for nearly 30 months.… More >

Mairaj Bibi¹, Muhammad Shoaib Arif ², Yasir Nawaz³, Nabil Kerdid^4,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.1, pp. 537-569, 2025, DOI:10.32604/cmes.2025.070362 - 30 October 2025

Abstract This study develops a high-order computational scheme for analyzing unsteady tangent hyperbolic fluid flow with variable thermal conductivity, thermal radiation, and coupled heat and mass transfer effects. A modified two-stage Exponential Time Integrator is introduced for temporal discretization, providing second-order accuracy in time. A compact finite difference method is employed for spatial discretization, yielding sixth-order accuracy at most grid points. The proposed framework ensures numerical stability and convergence when solving stiff, nonlinear parabolic systems arising in fluid flow and heat transfer problems. The novelty of the work lies in combining exponential integrator schemes with compact… More >

Shuo Wang, Yang Chen, Jia Li^*, Qihong Fang^*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.4, pp. 1-1, 2025, DOI:10.32604/icces.2025.010700

Abstract High entropy alloys (HEA) are considered as the candidate materials for the next generation of nuclear systems due to the excellent high temperature properties and radiation resistance. However, for the lack of atomic lattice distortion information from the micromechanical description, the existing simulation methods are difficult to capture the microstructure and damage evolution of the HEA at submicron scale. To address this, we develop the random field theory informed discrete dislocation dynamics simulations based on the results of high-resolution transmission electron microscopy to systematically clarify the role of heterogeneous lattice strain on the complex interactions… More >

Dong Liu¹, Runze Zhang¹, Anjie Hu¹, Na Liu¹, Liu Tang^2,3,*, Xiaozhou Wu⁴, Jun Wang^2,5

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.10, pp. 2579-2612, 2025, DOI:10.32604/fdmp.2025.070407 - 30 October 2025

Abstract This study compares two end-cooling systems, convective–radiant combined cooling (FR+FC) and fan coil convection (FC), through continuous experimental investigations, focusing on the impact of window-to-wall ratio (WWR) on indoor thermal comfort, temperature distribution, humidity, and energy consumption. Results show that increasing WWR amplifies indoor temperature fluctuations. While the overall predicted mean vote (PMV) remains within the Level-II comfort range (−1.0 to +1.0), the FC system exhibits pronounced local PMV gradients near west-facing windows, especially at 80% WWR, where transient PMV reaches 1.26 close to the window, 0.89 higher than at the room center. In contrast, More >

Weizheng Lu, Shuo Wang, Yang Chen, Jia Li^*, Qihong Fang^*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.3, pp. 1-1, 2025, DOI:10.32604/icces.2025.010711

Abstract The multi-principal elemental alloys (MPEAs) exhibit excellent combinations of mechanical properties and radiation-resistant, are considered potential candidates for aerospace industries and advanced reactors. However, the quantitative contribution of microstructure on the strengthening mechanism remains challenging at the micro-scale, which greatly limits the long-term application. To address this, we developed a hierarchical multiscale simulation framework that covers potential physical mechanisms to explore the hardening effects of chemical short-range order (CSRO) and irradiation defects in MPEA. Firstly, by combining atomic simulation, discrete dislocation dynamics, and crystal plasticity finite element method, a hierarchical cross-scale model covering heterostructure lattice… More >

Shaik Mohammed Ibrahim¹, Bhavanam Naga Lakshmi², Chundru Maheswari³, Hasan Koten^4,*

Frontiers in Heat and Mass Transfer, Vol.23, No.5, pp. 1555-1574, 2025, DOI:10.32604/fhmt.2025.069392 - 31 October 2025

Abstract Magnetohydrodynamic (MHD) radiative chemically reactive mixed convection flow of a hybrid nanofluid (Al₂O₃–Cu/H₂O) across an inclined, porous, and stretched sheet is examined in this study, along with its unsteady heat and mass transport properties. The hybrid nanofluid’s enhanced heat transfer efficiency is a major benefit in high-performance engineering applications. It is composed of two separate nanoparticles suspended in a base fluid and is chosen for its improved thermal properties. Thermal radiation, chemical reactions, a transverse magnetic field, surface stretching with time, injection or suction through the porous medium, and the effect of inclination, which introduces gravity-induced… More >

Pennelli Saila Kumari¹, Shaik Mohammed Ibrahim^1,*, Prathi Vijaya Kumar², Giulio Lorenzini^3,*

Frontiers in Heat and Mass Transfer, Vol.23, No.5, pp. 1639-1660, 2025, DOI:10.32604/fhmt.2025.069063 - 31 October 2025

Abstract In this paper, the authors examine various slip effects on the magnetic field and thermal radiative impacts on the flow, mass and heat transfer of a Jeffrey nanofluid over a 2-dimensional inclined stretching sheet by a porous media. The offered work is modelled to be in the form of a combination of coupled highly nonlinear partial differential equations in dimensional contexts. Governing equations were obtained, dimensionless parameters were defined in terms of similarity parameters, and the solutions were obtained by the Homotopy Analysis Method (HAM). The analysis is significant as the effects of viscosity are… More >

Shekaina Justin^1,*, Wafaa Saleh², Hind Mohammed Albalawi³, J. Shermina⁴

CMC-Computers, Materials & Continua, Vol.85, No.3, pp. 5469-5487, 2025, DOI:10.32604/cmc.2025.066888 - 23 October 2025

Abstract Solar radiation is the main source of energy on Earth and plays a major role in the hydrological cycles, surface radiation balance, weather and climate changes, and vegetation photosynthesis. Accurate solar radiation prediction is of paramount importance for both climate research and the solar industry. This prediction includes forecasting techniques and advanced modeling to evaluate the amount of solar energy available at a specific location during a given period. Solar energy is the cheapest form of clean energy, and due to the intermittent nature of the energy, accurate forecasting across multiple timeframes is necessary for… More >

Jun Li^1,#, Yang Chen^1,#, Zhijiao Hao², Zhiyong Zhang³, Jingyi Fan¹, Xiao Liu¹, Xueli Zhao³, Hongyan Zhang⁴, Chenpeng Wu^3,*

Oncology Research, Vol.33, No.11, pp. 3523-3541, 2025, DOI:10.32604/or.2025.067535 - 22 October 2025

Abstract Background: Radiation sensitive 23 homolog B (RAD23B), a DNA repair-related protein, plays a contributory role in the development of multiple malignancies. This study aimed to explore the role of RAD23B in promoting colorectal cancer (CRC) metastasis and to elucidate the underlying molecular mechanisms. Methods: RAD23B was overexpressed in CRC cell lines SW480 and HCT-8, with empty vectors serving as controls. Invasion, cell proliferation, and migration were assessed using CCK-8 and Transwell assays. A xenograft mouse model was used to evaluate metastatic potential in vivo. Immunoprecipitation-mass spectrometry (IP-MS) and transcriptomic analysis by RNA sequencing (RNA-seq) were performed… More >