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  • Open Access


    Retrospective Analysis of Postprandial Glucose-Response Data Collected in a Free-Living Environment

    Colleen Crangle1,2,*, Bude Piccin2, Lara Hyde3, Elin Östman4

    Journal of Intelligent Medicine and Healthcare, Vol.1, No.2, pp. 91-102, 2022, DOI:10.32604/jimh.2022.038379

    Abstract Postprandial glucose responses provide vital information on an individual’s risk of major diet-related chronic diseases. This study features digital health technology, namely Continuous Glucose Monitoring (CGM) sensors, along with mobile devices (iPhones running an app) used to collect data from individuals and their environment, specifically nutritional information on what they eat and drink. The paper presents a retrospective analysis of data collected during an investigation into the use of a functional drink taken as a supplement with a standardized meal to reduce postprandial responses to that meal. Given that there are consequential differences between individuals in their postprandial glucose responses,… More >

  • Open Access


    Vinorelbine in Non-Small Cell Lung Cancer: Real-World Data From a Single-Institution Experience

    Stefania Nobili*, Daniele Lavacchi, Gabriele Perrone*, Giulio Vicini, Renato Tassi‡1, Ida Landini*, AnnaMaria Grosso§, Giandomenico Roviello, Roberto Mazzanti, Carmine Santomaggio¶2, Enrico Mini

    Oncology Research, Vol.28, No.3, pp. 237-248, 2020, DOI:10.3727/096504019X15755437099308

    Abstract The use of vinorelbine as a single agent or in combination regimens in non-small cell lung cancer (NSCLC) is associated with satisfactory clinical activity. However, the role of vinorelbine-based chemotherapy in chemonaive locally advanced unresectable or metastatic NSCLC patients, according to real-world treatment patterns, has still not been widely explored. Eighty-one patients treated at a single institution were retrospectively analyzed. Thirty-seven received standard first-line single-agent vinorelbine, and 44 received vinorelbine plus platinum drugs, based on physician’s choice; 61.7% were older than 70 years, and 60.5% were affected by 2 comorbidities. Sixty-three patients were evaluable for objective response: 22% achieved partial… More >

  • Open Access


    Real-World Data: Fruquintinib in Treating Metastatic Colorectal Cancer

    Shuai Liu*†1, Lu Lu*†1, Feng Pan, Chunsheng Yang*†, Jing Liang§, Jinfeng Liu, Jian Wang#, Rong Shen**, Fu-Ze Xin††, Nan Zhang*†

    Oncology Research, Vol.29, No.1, pp. 25-31, 2021, DOI:10.3727/096504022X16427607626672

    Abstract Fruquintinib, also called HMPL-013, was first discovered by Hutchison Whampoa Pharmaceuticals Co. Ltd., Shanghai, China, and it is an oral vascular endothelial growth factor receptor (VEGFR) inhibitor. In clinical trials, fruquintinib has demonstrated a survival benefit in metastatic colorectal cancer (mCRC) patients. The purpose of this study was to retrospectively evaluate the efficacy and toxicity of fruquintinib in real-world patients. We collected data from patients with mCRC treated with oral fruquintinib from 2018 to 2020 in six different institutions. Patients with mCRC initially received 5 mg of oral fruquintinib daily for 3 weeks. Progression-free survival (PFS) was evaluated using the… More >

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