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  • Open Access


    Glycated Hemoglobin HbA1c: Permittivity Experimental Applications with Some Mathematical Concepts, Temperature and Frequency Variations

    Soliman Abdalla1,2,*, Sherif Kandil2, Waleed El-Shirbeeny1, Fatma Bahabri1,3

    Journal of Renewable Materials, Vol.10, No.9, pp. 2335-2354, 2022, DOI:10.32604/jrm.2022.021211

    Abstract Diabetes disorder turns smoothly to be a global epidemic disorder and the glycated hemoglobin (HbA1c) starts to be an efficient marker of it. The dielectric spectroscopy on different human normal- and diabetic-blood samples is used to characterize and to estimate the HbA1c concentration. “dc-” and ac-measurement of the complex conductivity in the temperature range from 280 K up to 320 K, and in the frequency range from one Hz up to 32 MHz have been performed. The thermal activation energy, ΔEσ, of dc-electric conductivity lies in the range 95 meV < ΔEσ < 115 meV; while the thermal activation energy,… More >

  • Open Access


    Investigation on Energy Characteristic of RBCs Deformability: A Quantitative Analysis of Extending and Retracting Curves Based on AFM

    Dong Chen1, Xiang Wang1,*, Fuzhou Tang2, Yajin Zhao1

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 150-150, 2019, DOI:10.32604/mcb.2019.07071

    Abstract Deformability is a fundamental property of the cells and tissues of living organisms, which is commonly detected to indicate the state of the cells. And the cell deformability usually depends on the methods that we used, which is easy to be confused. The present research is designed to explore the energy characteristic of red blood cell deformability, based on a quantitative analysis of extending-retracting curves acquired from atomic force microscopy. ATP-depleted red blood cells are prepared by treatment with free-glucose Ringer solution. Our results clearly show that the Youngs’ modulus of erythrocyte is closely depended on the concentration of intracellular… More >

  • Open Access


    Mechanosensing Dynmics of Red Blood Cells

    Sitong Zhou1, Jiandi Wan1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 70-70, 2019, DOI:10.32604/mcb.2019.06978

    Abstract Piezo proteins (Piezo1 and Piezo2) are recently identified mechanically activated cation channels in eukaryotic cells and associated with physiological responses to touch, pressure, and stretch. In particular, human RBCs express Piezo1 on their membranes, and mutations of Piezo1 have been linked to hereditary xerocytosis. To date, however, physiological functions of Piezo1 on normal RBCs remain poorly understood. Here, we show that Piezo1 regulates mechanotransductive release of ATP from human RBCs by controlling the shear-induced Ca2+ influx [1]. We find that, in human RBCs treated with Piezo1 inhibitors or having mutant Piezo1 channels, the amounts of shear-induced ATP release and Ca2+… More >

  • Open Access


    In Vitro Measurement of Blood Flow in Microvascular Network with Realistic Geometry

    Ken-ichi Tsubota1,2,*, Yuya Kodama1, Hiroyoshi Aoki2, Yutaka Yamagata2

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 38-39, 2019, DOI:10.32604/mcb.2019.07285

    Abstract We measured a blood flow in a polydimethysiloxane micro channel to reflect the complex geometry of a microvascular network. A flow rate was compared between two working fluids: water and blood. The measured flow rate reflected the bifurcation effects on the apparent viscosity determined by hematocrit, as well as the effects of the surrounding flow channels as bypasses. More >

  • Open Access


    Nonlinear Elastic and Viscoelastic Deformation of the Human Red Blood Cell with Optical Tweezers

    J. P. Mills1,1, L. Qie2,2, M. Dao1,1, C. T. Lim2,2, S. Suresh1,3

    Molecular & Cellular Biomechanics, Vol.1, No.3, pp. 169-180, 2004, DOI:10.3970/mcb.2004.001.169

    Abstract Studies of the deformation characteristics of single biological cells can offer insights into the connections among mechanical state, biochemical response and the onset and progression of diseases. Deformation imposed by optical tweezers provides a useful means for the study of single cell mechanics under a variety of well-controlled stress-states. In this paper, we first critically review recent advances in the study of single cell mechanics employing the optical tweezers method, and assess its significance and limitations in comparison to other experimental tools. We then present new experimental and computational results on shape evolution, force--extension curves, elastic properties and viscoelastic response… More >

  • Open Access


    Simulation of a Single Red Blood Cell Flowing Through a Microvessel Stenosis Using Dissipative Particle Dynamics

    L. L. Xiao, S. Chen∗,†, C. S. Lin, Y. Liu

    Molecular & Cellular Biomechanics, Vol.11, No.1, pp. 67-85, 2014, DOI:10.3970/mcb.2014.011.067

    Abstract The motion and deformation of a single red blood cell flowing through a microvessel stenosis was investigated employing dissipative particle dynamics (DPD) method. The numerical model considers plasma, cytoplasm, the RBC membrane and the microvessel walls, in which a three dimensional coarse-grained spring network model of RBC’s membrane was used to simulate the deformation of the RBC. The suspending plasma was modelled as an incompressible Newtonian fluid and the vessel walls were regarded as rigid body. The body force exerted on the free DPD particles was used to drive the flow. A modified bounce-back boundary condition was enforced on the… More >

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