Soliman Abdalla^1,2,*, Sherif Kandil², Waleed El-Shirbeeny¹, Fatma Bahabri^1,3

Journal of Renewable Materials, Vol.10, No.9, pp. 2335-2354, 2022, DOI:10.32604/jrm.2022.021211

Abstract Diabetes disorder turns smoothly to be a global epidemic disorder and the glycated hemoglobin (HbA1c) starts to be an efficient marker of it. The dielectric spectroscopy on different human normal- and diabetic-blood samples is used to characterize and to estimate the HbA1c concentration. “dc-” and ac-measurement of the complex conductivity in the temperature range from 280 K up to 320 K, and in the frequency range from one Hz up to 32 MHz have been performed. The thermal activation energy, ΔE_σ, of dc-electric conductivity lies in the range 95 meV < ΔE_σ < 115 meV; while the thermal activation energy,… More >

Dong Chen¹, Xiang Wang^1,*, Fuzhou Tang², Yajin Zhao¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 150-150, 2019, DOI:10.32604/mcb.2019.07071

Abstract Deformability is a fundamental property of the cells and tissues of living organisms, which is commonly detected to indicate the state of the cells. And the cell deformability usually depends on the methods that we used, which is easy to be confused. The present research is designed to explore the energy characteristic of red blood cell deformability, based on a quantitative analysis of extending-retracting curves acquired from atomic force microscopy. ATP-depleted red blood cells are prepared by treatment with free-glucose Ringer solution. Our results clearly show that the Youngs’ modulus of erythrocyte is closely depended on the concentration of intracellular… More >

Sitong Zhou¹, Jiandi Wan^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 70-70, 2019, DOI:10.32604/mcb.2019.06978

Abstract Piezo proteins (Piezo1 and Piezo2) are recently identified mechanically activated cation channels in eukaryotic cells and associated with physiological responses to touch, pressure, and stretch. In particular, human RBCs express Piezo1 on their membranes, and mutations of Piezo1 have been linked to hereditary xerocytosis. To date, however, physiological functions of Piezo1 on normal RBCs remain poorly understood. Here, we show that Piezo1 regulates mechanotransductive release of ATP from human RBCs by controlling the shear-induced Ca2+ influx [1]. We find that, in human RBCs treated with Piezo1 inhibitors or having mutant Piezo1 channels, the amounts of shear-induced ATP release and Ca2+… More >

Ken-ichi Tsubota^1,2,*, Yuya Kodama¹, Hiroyoshi Aoki², Yutaka Yamagata²

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 38-39, 2019, DOI:10.32604/mcb.2019.07285

Abstract We measured a blood flow in a polydimethysiloxane micro channel to reflect the complex geometry of a microvascular network. A flow rate was compared between two working fluids: water and blood. The measured flow rate reflected the bifurcation effects on the apparent viscosity determined by hematocrit, as well as the effects of the surrounding flow channels as bypasses. More >

J. P. Mills^1,1, L. Qie^2,2, M. Dao^1,1, C. T. Lim^2,2, S. Suresh^1,3

Molecular & Cellular Biomechanics, Vol.1, No.3, pp. 169-180, 2004, DOI:10.3970/mcb.2004.001.169

Abstract Studies of the deformation characteristics of single biological cells can offer insights into the connections among mechanical state, biochemical response and the onset and progression of diseases. Deformation imposed by optical tweezers provides a useful means for the study of single cell mechanics under a variety of well-controlled stress-states. In this paper, we first critically review recent advances in the study of single cell mechanics employing the optical tweezers method, and assess its significance and limitations in comparison to other experimental tools. We then present new experimental and computational results on shape evolution, force--extension curves, elastic properties and viscoelastic response… More >

L. L. Xiao^∗, S. Chen^∗,†, C. S. Lin^∗, Y. Liu^‡

Molecular & Cellular Biomechanics, Vol.11, No.1, pp. 67-85, 2014, DOI:10.3970/mcb.2014.011.067

Abstract The motion and deformation of a single red blood cell flowing through a microvessel stenosis was investigated employing dissipative particle dynamics (DPD) method. The numerical model considers plasma, cytoplasm, the RBC membrane and the microvessel walls, in which a three dimensional coarse-grained spring network model of RBC’s membrane was used to simulate the deformation of the RBC. The suspending plasma was modelled as an incompressible Newtonian fluid and the vessel walls were regarded as rigid body. The body force exerted on the free DPD particles was used to drive the flow. A modified bounce-back boundary condition was enforced on the… More >