Kennedy E. Okhawere¹, Ralph Grauer¹, Indu Saini¹, Iretiayo T. Joel¹, Alp Tuna Beksac², Oluwatoyin Ayo-Farai¹, Rutul Patel¹, Talia G. Korn¹, Kirolos N. Meilika¹, Najimdin Pedro¹, Ketan K. Badani¹

Canadian Journal of Urology, Vol.31, No.5, pp. 11992-12003, 2024

Abstract Introduction: We aim to identify factors associated with surgical refusal and non-surgical candidacy in clinical stage I kidney masses and to evaluate their impact on overall survival (OS).
Materials and methods: We conducted a retrospective cohort study using the National Cancer Database of patients with clinical stage I kidney cancer between 2004 and 2017. Logistic regression was used to determine baseline sociodemographic-, clinical-, and treatment facility-related factors associated with surgical refusal and non-surgical candidacy. Patients were 1.1 propensity score-matched and Cox regression analysis evaluated the impact of surgical refusal and non-surgical candidacy on OS.
Results: Compared to those… More >

Fuat Turk^1,*, Murat Luy², Necaattin Barışçı³, Fikret Yalçınkaya⁴

Intelligent Automation & Soft Computing, Vol.33, No.1, pp. 349-363, 2022, DOI:10.32604/iasc.2022.023710 - 05 January 2022

Abstract Cases of kidney cancer have shown a rapid increase in recent years. Advanced technology has allowed bettering the existing treatment methods. Research on the subject is still continuing. Medical segmentation is also of increasing importance. In particular, deep learning-based studies are of great importance for accurate segmentation. Tumor detection is a relatively difficult procedure for soft tissue organs such as kidneys and the prostate. Kidney tumors, specifically, are a type of cancer with a higher incidence in older people. As age progresses, the importance of having diagnostic tests increases. In some cases, patients with kidney More >

Jing Fu^1,2, Jun Ye³, Liping Xie^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.130, No.3, pp. 1751-1769, 2022, DOI:10.32604/cmes.2022.018739 - 30 December 2021

Abstract Since existing selection methods of surgical treatment schemes of renal cancer patients mainly depend on physicians’ clinical experience and judgments, the surgical treatment options of renal cancer patients lack their scientifical and reasonable information expression and group decision-making model for renal cancer patients. Fuzzy multi-sets (FMSs) have a number of properties, which make them suitable for expressing the uncertain information of medical diagnoses and treatments in group decision-making (GDM) problems. To choose the most appropriate surgical treatment scheme for a patient with localized renal cell carcinoma (RCC) (T1 stage kidney tumor), this article needs to… More >

Doreen A. Ezeife¹, Brendon Josh Morganstein², Steven Yip¹, Malcolm Ryan², Jennifer H. Law², Amy Yimin Guan³, Lisa W. Le³, Aaron R. Hansen², Adrian Sacher², Georg A. Bjarnason⁴, Mark K. Doherty⁴, Natasha B. Leighl²

Canadian Journal of Urology, Vol.28, No.4, pp. 10762-10767, 2021

Abstract Introduction: Advances in novel treatment options may render renal cell cancer (RCC) patients susceptible to the financial toxicity (FT) of cancer treatment, and the factors associated with FT are unknown.
Materials and methods: Eligible patients were ≥ 18 years old and had a diagnosis of stage IV RCC for at least 3 months. Patients were recruited from Princess Margaret Cancer Centre and Sunnybrook Odette Cancer Centre (Toronto, Canada). FT was assessed using the validated Comprehensive Score for Financial Toxicity (COST) instrument, a 12-question survey scored from 0-44, with lower scores reflecting worse FT. Patient and treatment characteristics,… More >

HASSAN M. OTIFI¹, MISHARI ALSHYARBA², MAJED AL FAYI^3,4, AYED A. DERA^3,4, PRASANNA RAJAGOPALAN^3,4,*

Oncology Research, Vol.29, No.3, pp. 217-227, 2021, DOI:10.32604/or.2022.03570 - 01 August 2022

Abstract Targeted therapies are gaining global attention to tackle Renal Cancer (RC). This study aims to screen FPMXY- 14 (novel arylidene analogue) for Akt inhibition by computational and in vitro methods. FPMXY-14 was subjected to proton NMR analysis and Mass spectrum analysis. Vero, HEK-293, Caki-1, and A498 cell lines were used. Akt enzyme inhibition was studied with the fluorescent-based kit assay. Modeller 9.19, Schrodinger 2018-1, LigPrep module, and Glide docking were used in computational analysis. The nuclear status was assessed by PI/Hoechst- 333258 staining, cell cycle, and apoptosis assays were performed using flow cytometry. Scratch wound and… More >

Kellan F. Clark¹, Matthew Risendal¹, Sharon Hill², Samuel Deem³

Canadian Journal of Urology, Vol.26, No.2, pp. 9715-9719, 2019

Abstract Introduction: The TNM staging system is used globally as the standard for interpreting the extent of cancer. Currently, T3a renal cell carcinoma is classified as tumor extending into the perinephric fat or renal vein. Prognostic outcomes may vary among renal cell carcinomas with renal vein involvement (RVI) versus those with perinephric fat involvement (PFI).
Materials and methods: We reviewed the medical records of all patients who underwent radical or partial nephrectomy at our institution by a single group of urologists between 2000 and 2014. After identifying those patients with T3a renal cell carcinoma, we further analyzed their… More >

Peter Chang^1,2,*, Peter Renehan^2,*, Kimberly N. Taylor¹, Lauren E. Dewey¹, Kyle C. McAnally¹, Sara Hyde¹, Catrina M. Crociani¹, Arie Carneiro^3,4, Lisa T. Beaule⁵, Andrew A. Wagner^1,2

Canadian Journal of Urology, Vol.25, No.4, pp. 9401-9406, 2018

Abstract Introduction: Hospital-related costs of renal cancer surgery have been described, but the societal costs of surgery-related lost productivity are poorly understood. We estimated the societal cost of renal cancer surgery by assessing surgery-related time off work (TOW) taken by patients and their caretakers.
Materials and methods: A total of 413 subjects who underwent partial or radical nephrectomy enrolled in an IRB-approved prospective study received an occupational survey assessing employment status, work physicality, income, surgery-related TOW, and caretaker assistance. We excluded subjects with incomplete occupational information or metastatic disease. We estimated potential wages lost using individual income and… More >

Makoto Isono, Akinori Sato, Kazuki Okubo, Takako Asano, Tomohiko Asano

Oncology Research, Vol.24, No.5, pp. 327-335, 2016, DOI:10.3727/096504016X14666990347635

Abstract The histone deacetylase (HDAC) inhibitor belinostat increases the amount of unfolded proteins in cells by promoting the acetylation of heat shock protein 90 (HSP90), thereby disrupting its chaperone function. The human immunodeficiency virus protease inhibitor ritonavir, on the other hand, not only increases unfolded proteins by suppressing HSP90 but also acts as a proteasome inhibitor. We thought that belinostat and ritonavir together would induce endoplasmic reticulum (ER) stress and kill renal cancer cells effectively. The combination of belinostat and ritonavir induced drastic apoptosis and inhibited the growth of renal cancer cells synergistically. Mechanistically, the combination More >

Pei Yin^*1, Jinpeng Jia^†1, Jijun Li^*, Yan Song^*, Yiyan Zhang^*, Fengkun Chen^*

Oncology Research, Vol.24, No.1, pp. 65-72, 2016, DOI:10.3727/096504016X14587366983838

Abstract Renal cell carcinoma (RCC) is the most common malignancy in the kidney in the world, and the 5-year overall survival for patients remains poor due to the lack of effective treatment strategies. Although ABT-737, as a Bcl-2/Bcl-xL inhibitor, has recently emerged as a novel cancer therapeutic reagent, apoptosis induced by ABT-737 is often blocked in several types of cancer cells. This study investigated whether the combination of the small-molecule BH3 mimetic ABT-737 and the lysosome inhibitor chloroquine was an effective strategy for treating renal cancer cells. We found that the combination of ABT-737 and chloroquine… More >

Zubair Cheema, Mazen Alsinnawi, Rowan G. Casey, John Corr

Canadian Journal of Urology, Vol.21, No.3, pp. 7277-7282, 2014

Abstract Introduction: Different techniques are used in open partial nephrectomy (OPN) for localized renal cancer, with variable impact on renal function. Regional renal ischemia technique by using different clamps and without the need to occlude renal vessels is gaining popularity. In our study, we present the largest international series; and the first in the United Kingdom; describing OPN using soft bowel clamp. We study the impact of this regional ischemia innovative technique on renal function, postoperative complications and oncological outcomes.
Materials and methods: We retrospectively analyzed the first 100 OPN cases done between 2001 and 2011. All available… More >