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  • Open Access

    REVIEW

    Nanomechanics and Ultrastructure of Bone: A Review

    Mohammad Maghsoudi-Ganjeh, Xiaodu Wang*, Xiaowei Zeng*

    CMES-Computer Modeling in Engineering & Sciences, Vol.125, No.1, pp. 1-32, 2020, DOI:10.32604/cmes.2020.012123

    Abstract In this review, a brief presentation is first given to the hierarchical structure and mechanical behavior of bone. Then, the recent advancements in nanoscale characterization of bone ultrastructure and ingredients are discussed based on an extensive quantity of references in the literature.Moreover, computational and analytical bone mechanics at ultrastructure levels are critically reviewed with the growing body of knowledge in the field. The computational and analytical models are summarized in several categories for ease of understanding bone nanomechanics and their applicability/limitations. This review is expected to provide a well-informed foundation for the researchers interested in interrogating the complex biomechanical response… More >

  • Open Access

    ARTICLE

    Simulation and Modeling of Laser-Tissue Interactions Based on a Liposome-Dye System

    F.E. Mensah∗,†, R. Sridhar, P. Misra

    Molecular & Cellular Biomechanics, Vol.7, No.4, pp. 203-212, 2010, DOI:10.3970/mcb.2010.007.203

    Abstract This work presents an overview of the use of liposomes for targeted delivery of photosensitizers to tumors for Photodynamic Therapy (PDT). It assesses the results of a quantitative model to explain the interaction of short-pulsed lasers (in the nanosecond and picosecond domains) with a liposome-dye complex in terms of a localized photo-induced thermal mechanism. Incorporation of an organic dye (sulforhodamine) within lipid vesicles has been investigated in conjunction with the effect of laser irradiation on the integrity of the liposome-dye complex. The variation of the absorption coefficient as a function of wavelength for dye-encapsulated liposomes before and after laser-induced release… More >

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