Zhedian Zhou¹, Tal Geva², Rahul H. Rathod², Alexander Tang², Chun Yang³, Kristen L. Billiar⁴, Dalin Tang^1,*,3, Pedro del Nido⁵

Molecular & Cellular Biomechanics, Vol.15, No.2, pp. 99-115, 2018, DOI: 10.3970/mcb.2018.00558

Abstract Patients with repaired Tetralogy of Fallot (ToF), a congenital heart defect which includes a ventricular septal defect and severe right ventricular outflow obstruction, account for the majority of cases with late onset right ventricle (RV) failure. The current surgical approach, which includes pulmonary valve replacement/insertion (PVR), has yielded mixed results. A computational parametric study using 7 patient-specific RV/LV models based on cardiac magnetic resonance (CMR) data as "virtual surgery" was performed to investigate the impact of patch size, RV remodeling and tissue regeneration in PVR surgery design on RV cardiac functions. Two patch sizes, three degrees of scar trimming (RV… More >

D.D. D’Lima^*, P.C. Chen^†, O. Kessler^‡, H.R. Hoenecke^*, C.W. Colwell Jr.^∗§

Molecular & Cellular Biomechanics, Vol.8, No.2, pp. 123-134, 2011, DOI:10.3970/mcb.2011.008.123

Abstract The menisci are important biomechanical components of the knee. We developed and validated a finite element model of meniscal replacement to assess the effect of surgical fixation technique on contact behavior and knee stability. The geometry of femoral and tibial articular cartilage and menisci was segmented from magnetic resonance images of a normal cadaver knee using MIMICS (Materialise, Leuven, Belgium). A finite element mesh was generated using HyperWorks (Altair Inc, Santa Ana, CA). A finite element solver (Abaqus v6.9, Simulia, Providence, RI) was used to compute contact area and stresses under axial loading and to assess stability (reaction force generated… More >

Dalin Tang^*, Chun Yang^†, Tal Geva^‡,§, Pedro J. del Nido^¶

Molecular & Cellular Biomechanics, Vol.4, No.3, pp. 159-176, 2007, DOI:10.3970/mcb.2007.004.159

Abstract A single-layer isotropic patient-specific right/left ventricle and patch (RV/LV/Patch) combination model with fluid-structure interactions (FSI) was introduced in our previous papers to evaluate and optimize human pulmonary valve replacement/insertion (PVR) surgical procedure and patch design. In this paper, an active anisotropic model with two-layer structure for ventricle wall and tissue fiber orientation was introduced to improve previous isotropic model for more accurate assessment of RV function and potential application in PVR surgery and patch design. A material-stiffening approach was used to model active heart contraction. The computational models were used to conduct ``virtual (computational)'' surgeries and test the hypothesis that… More >

Xiaorui Zhang^1,2,3,*, Jiali Duan¹, Jia Liu², Norman I. Badler³

CMC-Computers, Materials & Continua, Vol.60, No.3, pp. 1055-1071, 2019, DOI:10.32604/cmc.2019.03915

Abstract Current research on suture simulation mainly focus on the construction of suture line, and existing suture simulation systems still need to be improved in terms of diversity, soft tissue effects, and stability. This paper presents an integrated liver suture surgery system composed of three consecutive suture circumstances, which is conducive to liver suture surgery training. The physically-based models used in this simulation are based on different mass-spring models regulated by a special constrained algorithm, which can improve the model accuracy, and stability by appropriately restraining the activity sphere of the surrounding mass nodes around the suture points. We also studied… More >

Xiaorui Zhang^1,3,*, Jiali Duan¹, Lifeng Zhu², Ladislav Kavan³

CMC-Computers, Materials & Continua, Vol.57, No.3, pp. 505-519, 2018, DOI:10.32604/cmc.2018.01842

Abstract Puncture is a common operation in surgery, which involves all kinds of tissue materials with different geometry and mechanical properties. As a new cross-disciplinary research area, Virtual Surgery (VS) makes simulation of soft tissue in puncture operation possible in virtual environment. In this paper, we introduce a VS-based puncture system composed by three-layer soft tissue, simulated with spherical harmonic function (SHF), which is covered with a force mesh, constructed by mass spring model (MSM). The two models are combined together with a parameter of SHF named surface radius, which provides MSM with real-time deformation data needed in force calculation. Meanwhile,… More >

Xiaorui Zhang^1,2,3,*, Pengpai Wang¹, Wei Sun², Norman I. Badler³

CMC-Computers, Materials & Continua, Vol.55, No.2, pp. 297-319, 2018, DOI:10.3970/cmc.2018.01764

Abstract Real-time performance and accuracy are two most challenging requirements in virtual surgery training. These difficulties limit the promotion of advanced models in virtual surgery, including many geometric and physical models. This paper proposes a physical model of virtual soft tissue, which is a twist model based on the Kriging interpolation and membrane analogy. The proposed model can quickly locate spatial position through Kriging interpolation method and accurately compute the force change on the soft tissue through membrane analogy method. The virtual surgery simulation system is built with a PHANTOM OMNI haptic interaction device to simulate the torsion of virtual stomach… More >