Mohammed Majid Abed^1,2,*, Murat Aydin¹, Esma Yiğider¹, Melek Ekinci³, Ertan Yildirim³

Phyton-International Journal of Experimental Botany, Vol.94, No.12, pp. 3845-3860, 2025, DOI:10.32604/phyton.2025.073163 - 29 December 2025

Abstract Plants are continuously exposed to abiotic and biotic stresses that threaten their growth, reproduction, and survival. Adaptation to these stresses requires complex regulatory networks that coordinate physiological, molecular, and ecological responses. However, such adaptation often incurs significant costs, including reduced growth, yield penalties, and altered ecological interactions. This review systematically synthesizes recent advances published between 2018 and 2025, following PRISMA criteria, on plant responses to abiotic and biotic stressors, with an emphasis on the trade-offs between adaptation and productivity. It also highlights major discrepancies in the literature and discusses strategies for enhancing plant stress tolerance More >

Abdul Baseet Arham¹, John M. Rieth², Michael A. O’Donnell^3,*

Canadian Journal of Urology, Vol.32, No.6, pp. 605-620, 2025, DOI:10.32604/cju.2025.063632 - 30 December 2025

Abstract Background: Genitourinary (GU) sarcomas are rare soft tissue malignancies, comprising around 2% of all GU cancers. Due to their rarity, limited data exist on optimal management and long-term outcomes. This study presents a 25-year single-institution experience, evaluating clinical presentation, treatment strategies, and survival outcomes, aims to identify trends over time and potential predictors of prognosis. Methods: A retrospective review was conducted of patients aged ≥18 years diagnosed with GU sarcomas at the University of Iowa Hospitals and Clinics (1998–2023). Data on tumor subtype, staging, histopathology, treatment modalities, and survival outcomes were analyzed. Kaplan-Meier analysis estimated… More >

Manzhu Liao¹, Lan Yang¹, Liehua Tie¹, Qiqiang Guo^1,*, Weilie Zheng^2,*, Jiangrong Li², Yongxia Li²

Phyton-International Journal of Experimental Botany, Vol.94, No.11, pp. 3633-3652, 2025, DOI:10.32604/phyton.2025.072725 - 01 December 2025

Abstract Cupressus gigantea is an endemic endangered tree species in the Tibet Plateau, and studying the survival status of the different C. gigantea populations and revealing the main environmental factors that affect the population survival are particularly significant for the conservation and sustainable development of endangered species. Based on the 28 sample plots, the Hierarchical Cluster Method was used to classify the C. gigantea populations into four community types. Age structure diagrams were drawn based on the structure of each community, static life tables and survival curves were compiled, and the future development trends of each age group in… More >

Hui Yi^1,2,#, Hongjian Shi^2,3,#, Fuquan Kan^2,4,#, Fan Han², Lei Wan⁵, Xiaoyang Hong¹, Zhe Zhao¹, Junjie Shao², Gang Wang¹, Hui Wang¹, Hua Yan⁵, Xiujuan Shi¹, Ran Zhang^2,6,*, Gengxu Zhou^1,*

Congenital Heart Disease, Vol.20, No.4, pp. 519-530, 2025, DOI:10.32604/chd.2025.067164 - 18 September 2025

Abstract Background: To investigate the impact of preoperative extracorporeal membrane oxygenation (ECMO) on clinical outcomes in pediatric heart transplantation (PHT). Methods: This retrospective cohort analysis was conducted on 19 pediatric heart transplant recipients, divided into two groups: ECMO and non-ECMO, based on whether preoperative ECMO was utilized. We evaluated the patients’ surgical conditions, postoperative complications, and survival rates. Additionally, the analysis focused on the differences and correlations in clinical characteristics, inflammatory markers, and long-term survival outcomes. Results: There was no statistically significant difference in perioperative survival rates between the ECMO group (85.7%) and the non-ECMO group (83.3%). However,… More >

Meng Cao, Rundong Zhang, Anlan Hong, Shanyuan Ye, Zequn Qiu, Dongqing Li, Tong Lin^*, Yan Wang^*

Oncology Research, Vol.33, No.9, pp. 2507-2527, 2025, DOI:10.32604/or.2025.064780 - 28 August 2025

Abstract Introduction: Acral melanoma (AM) is the predominant subtype of cutaneous melanoma in Asian populations, characterized by more aggressive clinical features and limited neoadjuvant therapy response. Centrosomal protein 55 kDa (CEP55) has been implicated in the pathogenesis of various malignancies, but its role in AM remains undefined. Methods: CEP55 expression in melanoma tissues and cell lines was analyzed by RT-qPCR, Western blotting, and immunohistochemistry (IHC). Databases (GEPIA, Sangerbox, Kaplan-Meier plotter, and TIMER) were used to analyze the expression of CEP55 and its correlation with clinical data of melanoma patients. Functional assays were conducted in vitro and in vivo.… More >

Xiaobing Zhou^1,#, Ying Li^2,#, Zizi Jing¹, Wei Yu¹, Jianbin Chen^1,*

Oncology Research, Vol.33, No.9, pp. 2399-2420, 2025, DOI:10.32604/or.2025.063700 - 28 August 2025

Abstract Background: Multiple myeloma (MM) remains a formidable clinical challenge due to its high relapse rate and resistance to existing therapies. Estrogen-related receptor gamma (ERRγ), a nuclear receptor critical for cellular energy metabolism, has been implicated in various cancers. but its role in MM remains unclear. Methods: ERRγ expression was assessed using bioinformatics and RT-qPCR. Functional studies were conducted through siRNA-mediated ERRγ knockdown and treatment with the inverse agonist GSK5182 to examine their effects on MM cell proliferation and apoptosis. Results: ERRγ was significantly upregulated in the bone marrow of MM patients, correlating with advanced clinical stages… More > Graphic Abstract

Arjun Pon Avudaiappan^*, Pushan Prabhakar, Hannah Baker, Mukesh K. Roy, Manuel Ozambela Jr, Christopher Gomez, Murugesan Manoharan

Canadian Journal of Urology, Vol.32, No.3, pp. 137-143, 2025, DOI:10.32604/cju.2025.064725 - 27 June 2025

Abstract Introduction: Radical cystectomy with pelvic node dissection remains the standard of care for muscle-invasive bladder carcinoma (MIBC); however, there is a growing interest in bladder preservation alternatives among the elderly population. Guidelines indicate that partial cystectomy (PC) combined with pelvic node dissection (LND) can be considered as an alternative in carefully selected individuals. Using the National Cancer Database, we analyzed the overall survival (OS) between PC with and without LND among octogenarians. Methods: We identified octogenarians with localized muscle-invasive bladder carcinoma (cT2-3N0M0) and urothelial histology who underwent PC with or without LND between 2004 and… More >

ABDUR JAMIL¹, RIMSHA SIDDIQUE², FARYAL ALTAF³, DANIYAL WARRAICH⁴, FAIZAN AHMED⁵, ZAHEER QURESHI^6,*

Oncology Research, Vol.33, No.6, pp. 1289-1300, 2025, DOI:10.32604/or.2025.058790 - 29 May 2025

Abstract Background: Male breast cancer (MBC) is a rare but significant health concern, accounting for less than 1% of all breast cancer cases. Despite its low incidence, it presents unique clinical, genetic, and psychosocial challenges. Genetic predispositions, including BRCA2 mutations and hormonal imbalances, are key factors influencing the development of MBC. However, the rarity of the condition has led to limited research and fewer treatment guidelines specifically for male patients. Methods: A comprehensive literature review was conducted using PubMed, MEDLINE, and Embase databases to identify studies focusing on the epidemiology, risk factors, clinical presentation, diagnosis, treatment,… More >

Miguel Ángel Gómez-Luque^*, Guillermo Lendínez-Cano, Carmen Belén Congregado-Ruiz, Ignacio Osman-García, Rafael Antonio Medina-López

Canadian Journal of Urology, Vol.32, No.2, pp. 101-109, 2025, DOI:10.32604/cju.2025.063073 - 30 April 2025

Abstract Introduction: In recent years, significant advancements in the treatment of metastatic renal cell carcinoma (mRCC) have notably extended overall survival (OS) times, particularly with the introduction of tyrosine kinase inhibitors (TKIs) and combination immunotherapy. However, survival outcomes in mRCC remain highly variable. Materials and Methods: This study retrospectively analyzed clinical and demographic factors at diagnosis in patients treated for mRCC to identify predictors of long-term survival (defined as OS ≥ 48 months). Patients were categorized into long-term survivors (LTS) and non-long-term survivors (nLTS). Results: The analysis revealed that factors such as better Karnofsky Performance Status (KPS), More >

JIYUN PANG^1,2,#, WEIGANG XIU^1,#, YUEYUN CHEN⁴, WENJING LIAO^1,2, QIN ZHANG^3,*, HUASHAN SHI^4,*

Oncology Research, Vol.33, No.4, pp. 895-904, 2025, DOI:10.32604/or.2024.053363 - 19 March 2025

Abstract Background: Non-small cell lung cancer (NSCLC) is often accompanied by brain metastasis (BM), and the prognosis of patients with BM is poor. This study assesses the prognostic impact of BM in NSCLC patients with epidermal growth factor receptor (EGFR) mutations. Methods: We retrospectively evaluated 692 advanced NSCLC patients with EGFR mutations treated with tyrosine kinase inhibitors (TKIs) at West China Hospital from 2015 to 2019. The overall survival rate (OS), progression-free survival rate (PFS), objective response rate (ORR), disease control rate (DCR), and clinical parameters of the BM and non-BM groups were compared. Univariable and multivariable… More >