Jo Van Damme¹, Stijn Van Damme², Soffe Struyf¹, Ghislain Opdenakker³

European Cytokine Network, Vol.36, No.1, pp. 6-14, 2025, DOI:10.1684/ecn.2025.0501 - 05 January 2026

Abstract Since their discovery, chemotactic cytokines or chemokines have been intensively studied for about half a century. Chemokines originate from tissue cells, leukocytes, blood platelets and plasma. Here, we review a number of seminal findings on plasma chemokines within an historical and international context. These aspects include how induction and purification protocols led to the discovery of a new family of mediators, named chemokines, on the basis of protein sequencing; how molecular cloning techniques facilitated discoveries of additional family members on the basis of conserved protein structures; how blood plasma and platelets were used as a More >

Yi Feng^1,#, Haoxin Yang², Guicai Liang¹, Jun Chen³, Tao Li¹, Yingjuan Wang⁴, Jilin Chang¹, Yan Li³, Meng Yang¹, Xilong Zhou¹, Zhiqiang Wang^5,*, Chunlei Ge^1,*

Oncology Research, Vol.33, No.12, pp. 3801-3836, 2025, DOI:10.32604/or.2025.067824 - 27 November 2025

Abstract Immune checkpoint inhibitor (ICI) has limited efficacy in the treatment of immune “cold” tumors. Due to insufficient T cell infiltration and heterogeneous programmed death ligand 1 (PD-L1) expression, the ORR is only 5%–8% compared with 30%–40% of “hot” tumors. This article reviews the synergistic mechanism, clinical efficacy and optimization strategy of oncolytic virus (OVs) combined with ICIs in the treatment of refractory malignant tumors. Systematic analysis of mechanistic interactions across tumor types and clinical trial data demonstrates that OVs transform the immunosuppressive microenvironment by inducing immunogenic cell death and activating innate immunity. Concurrently, ICIs enhance… More >

Chuang Meng^1,*, Yutong Bi¹, Bingji Zhang¹, Wentao Fu², Guang Chen³

Structural Durability & Health Monitoring, Vol.19, No.6, pp. 1681-1694, 2025, DOI:10.32604/sdhm.2025.068732 - 17 November 2025

Abstract The lift-and-transverse type parking equipment, with its core advantages such as high space utilization, modular and flexible layout, and intelligent operation, has become an efficient solution to alleviate the urban parking problem. However, existing research still lacks a systematic evaluation of its structural performance, particularly in areas such as the fatigue characteristics of steel frame materials, stress distribution under dynamic loads, and resonance risk analysis. The stress amplitude (S) and fatigue life (N) relationship curve of Q235 steel, the material used in the steel frame of the lift-and-transverse type parking equipment, was obtained through fatigue… More >

Hafiza Muniba Din Muhammad¹, Safina Naz¹, Zarina Bibi², Mohamed A. A. Ahmed³, Alina-Stefania Stanciu⁴, Riaz Ahmad^5,*

Phyton-International Journal of Experimental Botany, Vol.94, No.9, pp. 2631-2648, 2025, DOI:10.32604/phyton.2025.069474 - 30 September 2025

Abstract The production of crops is badly affected by climate change globally. Mitigation of adverse effects of climate change is in need of time through different management practices such as developing tolerant genetic resources, hormonal applications to boost defense systems, nanoparticles, and balanced fertilization. The nano-hormonal synergy had the potential to mitigate the adverse effects of climate change by modulation of morpho-physiological and biochemical activities. Plant growth, yield, and quality can be enhanced with the supplementation of nano-hormonal interactions. Therefore, the current study explores the synergy between nanoparticles and phytohormonal use. The nanoparticles, even in low… More >

Cheng Yong^1,2,3,4,5, Enhui Sun^1,*, Xiaodong Fan^1,4, Zhiping Zhang⁵, Jing Zhang¹, Ling Chen¹, Ping Qu¹, Qiujun Wang¹, Hongying Huang¹, Hongmei Jin¹, Mingjie Guan^4,*

Journal of Renewable Materials, Vol.13, No.9, pp. 1803-1817, 2025, DOI:10.32604/jrm.2025.02025-0059 - 22 September 2025

Abstract Long-time fermentation has always been one of the reasons restricting the development of straw biological pulping. This study aimed to develop a novel straw pulp film with shortened solid-state fermentation time with less than 20% mass loss rate by bio-pulping synergistic treatment of straw fibers with deep eutectic solvent (DES) and Streptomyces rochei (S. rochei). Results illustrated that at 3% S. rochei concentration with 7-day fermentation, both cellulose and hemicellulose enzyme activities of the treated rice straw fiber reached peak values with a fiber mass loss rate of 17.01%. Microstructural morphology revealed that S. rochei colonization initiated on straw… More > Graphic Abstract

Sachin Sharma^1,2,*, Brajesh Kumar Singh³, Hitendra Garg²

CMC-Computers, Materials & Continua, Vol.82, No.3, pp. 4691-4708, 2025, DOI:10.32604/cmc.2025.061252 - 06 March 2025

Abstract Image tampering detection and localization have emerged as a critical domain in combating the pervasive issue of image manipulation due to the advancement of the large-scale availability of sophisticated image editing tools. The manual forgery localization is often reliant on forensic expertise. In recent times, machine learning (ML) and deep learning (DL) have shown promising results in automating image forgery localization. However, the ML-based method relies on hand-crafted features. Conversely, the DL method automatically extracts shallow spatial features to enhance the accuracy. However, DL-based methods lack the global co-relation of the features due to this… More >

Prashanth K P^1,*, Rudresh M², Venkatesh N³, Poornima Gubbi Shivarathri⁴, Shwetha Rajappa⁵

Journal of Renewable Materials, Vol.12, No.12, pp. 2115-2134, 2024, DOI:10.32604/jrm.2024.055437 - 20 December 2024

Abstract This study explores the mechanical properties of a novel composite material, blending polylactic acid (PLA) with sea shells, through a comprehensive tensile test analysis. The tensile test results offer valuable insights into the material’s behavior under axial loading, shedding light on its strength, stiffness, and deformation characteristics. The results suggest that the incorporation of sea shells decrease the tensile strength of 14.55% and increase the modulus of 27.44% for 15 wt% SSP (sea shell powder) into PLA, emphasizing the reinforcing potential of the mineral-rich sea shell particles. However, a potential trade-off between decreased strength and… More >

Jiangfeng Guo^1,2,3,*, Hongjie Yu¹

Frontiers in Heat and Mass Transfer, Vol.22, No.6, pp. 1575-1595, 2024, DOI:10.32604/fhmt.2024.058179 - 19 December 2024

Abstract Based on the first and second laws of thermodynamics, the heat transfer and flow (thermohydraulic) characteristics of horizontal supercritical pressure CO₂ (S-CO₂) in a circular pipe under heating conditions were investigated numerically. Heating flows in two different diameters (d) of 4 and 6 mm were simulated in pipes with pressures of 8 MPa, mass fluxes (G) of 300 and 400 kg/(m²·s), and heat fluxes (q) of 50, 75 and 100 kW/m². In the d = 4 mm pipe, the peak heat transfer coefficient (h_b) was about 3 times higher than in the d = 6 mm pipe, while the entropy… More > Graphic Abstract

Jiakai Li, Jianpeng Hu^*, Geng Zhang

CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 2481-2503, 2024, DOI:10.32604/cmc.2024.050005 - 15 May 2024

Abstract In the process of constructing domain-specific knowledge graphs, the task of relational triple extraction plays a critical role in transforming unstructured text into structured information. Existing relational triple extraction models face multiple challenges when processing domain-specific data, including insufficient utilization of semantic interaction information between entities and relations, difficulties in handling challenging samples, and the scarcity of domain-specific datasets. To address these issues, our study introduces three innovative components: Relation semantic enhancement, data augmentation, and a voting strategy, all designed to significantly improve the model’s performance in tackling domain-specific relational triple extraction tasks. We first… More >

Ali Akbar Firoozi^1,*, Ali Asghar Firoozi²

Structural Durability & Health Monitoring, Vol.18, No.1, pp. 1-18, 2024, DOI:10.32604/sdhm.2023.044573 - 11 January 2024

Abstract The discipline of damage tolerance assessment has experienced significant advancements due to the emergence of smart materials and self-repairable structures. This review offers a comprehensive look into both traditional and innovative methodologies employed in damage tolerance assessment. After a detailed exploration of damage tolerance concepts and their historical progression, the review juxtaposes the proven techniques of damage assessment with the cutting-edge innovations brought about by smart materials and self-repairable structures. The subsequent sections delve into the synergistic integration of smart materials with self-repairable structures, marking a pivotal stride in damage tolerance by establishing an autonomous More >