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Search Results (48)
  • Open Access

    RETRACTION

    Retraction: miR-144-3p targets FosB proto-oncogene, AP-1 transcription factor subunit (FOSB) to suppress proliferation, migration, and invasion of PANC-1 pancreatic cancer cells

    Oncology Research Editorial Office

    Oncology Research, Vol.33, No.3, pp. 735-735, 2025, DOI:10.32604/or.2024.056907 - 28 February 2025

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    TMED3 promotes prostate cancer via FOXO1a and FOXO3a phosphorylation

    XIUWANG WEI1, JIANBO LIANG1, HUANWEN HUANG1, DAMING YANG1, XINXIN WANG1, XIUJIA WANG1, CHANGSHENG CHEN1, KAIQIANG LI1, TAISEN PANG1, BIN HU1, FENGNING WU2,*

    Oncology Research, Vol.33, No.1, pp. 161-169, 2025, DOI:10.32604/or.2024.048054 - 20 December 2024

    Abstract Background: Transmembrane emp24 trafficking protein 3 (TMED3) is associated with the development of several tumors; however, whether TMED3 regulates the progression of prostate cancer remains unclear. Materials and Methods: Short hairpin RNA was performed to repress TMED3 in prostate cancer cells (DU145 cells) and in a prostate cancer mice model to determine its function in prostate cancer in vitro and in vivo. Results: In the present study, we found that TMED3 was highly expressed in prostate cancer cells. In vitro, shTMED3 treatment suppressed the proliferation, invasion, and migration and promoted the apoptosis of DU145 cells. Additionally, the Kyoto Encyclopedia… More >

  • Open Access

    ARTICLE

    The Maize WRKY Transcription Factor ZmWRKY25 Respond Drought Stress in Transgenic Tobacco

    Jianbo Fei1,2,4, Zhibo Liu1, Piwu Wang1,3, Jing Qu2, Siyan Liu1, Shuyan Guan1,3,*, Yiyong Ma1,3

    Phyton-International Journal of Experimental Botany, Vol.93, No.12, pp. 3617-3635, 2024, DOI:10.32604/phyton.2024.052704 - 31 December 2024

    Abstract The WRKY transcription factors play important roles in various biological processes such as plant development, defense regulation, and stress response. Despite this, there is limited information available on drought-related WRKY genes in maize. Through RNA sequencing (RNA-seq) analysis, a WRKY transcription factor called ZmWRKY25 was identified in this study. ZmWRKY25 belongs to Group II and is localized in the nucleus. Protein interaction analysis revealed that ZmWRKY25 interacts with several proteins involved in the abscisic acid (ABA) signal pathway. Expression of ZmWRKY25 was found to be up-regulated in response to drought, salt, and ABA treatments in tobacco plants. More >

  • Open Access

    ARTICLE

    Systematic Identification of Acer rubrum bZIP Transcription Factors and Their Potential Role in Anthocyanin Accumulation under Low Temperature with Light

    Yue Zhao1,2,#, Shah Faheem Afzal2,#, Zhu Chen2, Khan Arif Kamal1,2, Yuzhi Fei2, Xin Meng1,2, Jie Ren2,*, Hua Liu1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.11, pp. 3109-3130, 2024, DOI:10.32604/phyton.2024.056548 - 30 November 2024

    Abstract Acer rubrum is an important garden color-leafed plant. Its leaves will turn red in autumn, which is of great ornamental value. The leaf color change in Acer rubrum is closely associated with anthocyanins accumulation. In anthocyanin synthesis and accumulation, various transcription factor families play significant regulatory roles, including the basic (region) leucine zipper (bZIP). However, there is no report on the systematic identification and functional analysis of the bZIPs in Acer rubrum. In this study, 137 bZIPs distributed on 29 chromosomes of Acer rubrum were identified and renamed according to their locations on the chromosomes. According to the constructed… More >

  • Open Access

    ARTICLE

    Transcription Factors and Retained Intron Act Vital Roles in Cadmium Stress Response of Medicinal Model Plant Salvia miltiorrhiza

    Jun Yuan1, Rongpeng Liu4, Xiaoyun Wang3,*, Haihui Fu2,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.9, pp. 2267-2284, 2024, DOI:10.32604/phyton.2024.055338 - 30 September 2024

    Abstract Cadmium (Cd) has seriously affected the quality of traditional Chinese medicinal material Salvia miltiorrhiza in recent years, threatening human health. The physiological and metabolic profiles of S. miltiorrhiza in response to Cd stress have been revealed in previous studies. However, transcriptional and post-transcriptional regulation in response to different degrees of Cd (0, 25, 50, and 100 mg/kg) stress in S. miltiorrhiza remains unclear. Here, transcriptome atlas in S. miltiorrhiza under different degrees of Cd Stress was unveiled using RNA sequencing (RNA-seq). These results showed that the profiles of gene expression were different in the response to Cd treatment. Defense More >

  • Open Access

    ARTICLE

    Identification and Analysis of the WRKY Transcription Factor Gene Family in Verbena bonariensis

    Dandan Yuan, Ju Cai, Tao Zhang, Sisi Wang, Xiuliu Yang, Yan Li*

    Phyton-International Journal of Experimental Botany, Vol.93, No.8, pp. 1875-1896, 2024, DOI:10.32604/phyton.2024.052190 - 30 August 2024

    Abstract The WRKY transcription factor gene family is one of the unique gene families in plants. It plays an important role in response to abiotic stresses such as cold and drought, hormone signal transduction, regulation of biosynthesis, leaf senescence seed germination, etc. However, little information is available about WRKY transcription factors in Verbena bonariensis. In this study, 70 VbWRKY genes were identified from the whole genome. The phylogenetic analysis of the WRKY gene family in V. bonariensis and Arabidopsis shows that the WRKY genes in V. bonariensis can be divided into three groups: I, II, and III, which contain 13, 47, and… More >

  • Open Access

    ARTICLE

    Cu Stress-Induced Transcriptome Alterations in Sorghum and Expression Analysis of the Transcription Factor-Encoding Gene SbWRKY24

    Mingchuan Yang1, Jia Zheng2, Wenhui Yu1, Yanghua Li2, Yali Wang1, Zilu Zhang1, Zhenhui Kang1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.7, pp. 1503-1521, 2024, DOI:10.32604/phyton.2024.051718 - 30 July 2024

    Abstract Sorghum is not only an important bio-energy crop but also a vital raw material for brewing. Exogenous copper affects the growth and metabolism of crops in specific ways. This study identified 8475 differentially expressed genes (DEGs) by high-throughput transcriptome sequencing in the sorghum cultivar ‘Jinnuoliang 2’ after 24 h of treatment with 10 mM CuSO. Using GO analysis, 476 genes were functionally annotated, which were mainly related to catabolism and biosynthetic processes. Additionally, 90 pathways were annotated by employing the KEGG analysis. Among them, glutathione metabolism and peroxisome were induced, while photosynthesis, photosynthesis-antenna protein, and… More >

  • Open Access

    RETRACTION

    Retraction: Liquiritigenin Inhibits Colorectal Cancer Proliferation, Invasion, and Epithelial-to-Mesenchymal Transition by Decreasing Expression of Runt-Related Transcription Factor 2

    Oncology Research Editorial Office

    Oncology Research, Vol.32, No.8, pp. 1373-1373, 2024, DOI:10.32604/or.2024.055031 - 17 July 2024

    Abstract This article has no abstract. More >

  • Open Access

    CORRECTION

    Correction: MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

    HUI SUN, MASANORI KAWANO*, TATSUYA IWASAKI, ICHIRO ITONAGA, YUTA KUBOTA, HIROSHI TSUMURA, KAZUHIRO TANAKA

    Oncology Research, Vol.32, No.8, pp. 1369-1370, 2024, DOI:10.32604/or.2024.052652 - 17 July 2024

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    The NAC Transcription Factor ANAC089 Modulates Seed Vigor through the ABI5-VTC2 Module in Arabidopsis thaliana

    Yuan Tian, Lulu Zhi, Ping Li*, Xiangyang Hu*

    Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1101-1116, 2024, DOI:10.32604/phyton.2024.050220 - 27 June 2024

    Abstract Seed viability is an essential feature for genetic resource conservation as well as sustainable crop production. Long-term storage induces seed viability deterioration or seed aging, accompanied by the accumulation of toxic reactive oxygen species (ROS) to suppress seed germination. Controlled deterioration treatment (CDT) is a general approach for mimicking seed aging. The transcription factor ANAC089 was previously reported to modulate seed primary germination. In this study, we evaluated the ability of ANAC089 to control seed viability during aging. Compared with that in the wild-type line, the mutation of ANAC089 significantly increased HO, thereby reducing seed viability after… More >

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