Tao Zhu¹, Taofeng Wei¹, Mingdong Yang¹, Junjun Xu¹, Huifang Jiang¹, Wei He¹, Juyan Zheng^2,*, Haibin Dai^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070180 - 30 December 2025

Abstract Background: Aberrant expression of transcription factors (TFs) is a key mechanism mediating tumor immune escape and therapeutic resistance. The involvement of E26 transformation-specific (ETS) family of TFs in immune regulation is not fully understood. The study aimed to elucidate the function of E-twenty-six variant 4 (ETV4) in tumor immune evasion and its potential as a predictive biomarker for immunotherapy in melanoma. Methods: The expression patterns of ETS family TFs were analyzed in melanoma and hepatocellular carcinoma (HCC). Single-cell RNA sequencing (scRNA-seq) was used to dissect the cellular expression and function of ETV4 in the tumor… More >

Yongle Qiu^1,#, Kunshan Li^1,#, Wenjing Wang¹, Wenjuan Zhang², Jilun Liu², Yang Bai³, Fei Xu³, Jie Guo^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069612 - 30 December 2025

Abstract Background: The regulatory mechanisms governing vasculogenic mimicry (VM) in oral squamous cell carcinoma (OSCC) remain largely undefined. This study aimed to identify critical factors and elucidate the epigenetic mechanisms underlying VM in OSCC. Methods: Bioinformatics analysis was performed utilizing single-cell RNA-seq, bulk RNA-seq, and histone H3 lysine 27 acetylation (H3K27ac) Chromatin Immunoprecipitation (ChIP)-seq data obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. ChIP-qPCR was used to validate the binding of ETS transcription factor ELK4 (ELK4) to the dihydrofolate reductase (DHFR) enhancer. In vitro VM formation and invasion of OSCC cells were… More > Graphic Abstract

Nadia Lamsaadi¹, Oumaima Maarouf², Soukaina Lahmaoui², Hamid Msaad², Omar Farssi², Chaima Hamim², Mohamed Tamoudjout², Hafsa Hirt², Habiba Kamal², Majida El Hassni², Cherki Ghoulam^3,4, Ahmed El Moukhtari^5,*, Mohamed Farissi²

Phyton-International Journal of Experimental Botany, Vol.94, No.11, pp. 3585-3610, 2025, DOI:10.32604/phyton.2025.072311 - 01 December 2025

Abstract Abiotic stresses, such as drought, heavy metals, salinity, and extreme temperatures, are among the most common adverse threats that restrict the use of land for agriculture and limit crop growth and productivity. As sessile organisms, plants defend themselves from abiotic stresses by developing various tolerance mechanisms. These mechanisms are governed by several biochemical traits. The biochemical mechanisms are the products of key genes that express under specific conditions. Interestingly, the expression of these genes is regulated by specialized proteins known as transcription factors (TFs). Several TFs, including those from the bZIP, bHLH, MYB, HSF, WRKY,… More >

Qunlu Liu^1,#, Fiza Liaquat^1,2,#, Qiqi Tang¹, Jun Yang^3,4, Shuai Qiu⁵, Amber Malik², Kang Ye^3,4, Kai Gao⁵, Jun Qin^3,4,*

Phyton-International Journal of Experimental Botany, Vol.94, No.11, pp. 3539-3562, 2025, DOI:10.32604/phyton.2025.071989 - 01 December 2025

Abstract Hydrangea macrophylla is a popular ornamental shrub with a lot of economic and aesthetic value. It is known for its different flower shapes (lacecap and mophead) and the way its flowers change color depending on the pH of the soil. Even though it is important for gardening, we still don’t know much about the molecular processes that lead to flower growth. The purpose of this study was to find and study SNP-related genes and transcription factors that are connected to the growth of H. macrophylla flowers. Genome-wide SNP analysis identified 11 SNPs associated with MYB transcription factors… More >

Qinfu Sun, Junqiang Xing, Wanyu Zhang, Chen Lin^*

Phyton-International Journal of Experimental Botany, Vol.94, No.11, pp. 3349-3370, 2025, DOI:10.32604/phyton.2025.071525 - 01 December 2025

Abstract Extensive transcriptomic reprogramming is triggered by biotic and abiotic stresses in plants, with coordinated regulation mediated through multiple transcription factor families, such as WRKY, MYB, NAC, and BBX proteins. Among these, B-box (BBX) proteins represent a distinct class of zinc finger transcription factors characterized by the presence of conserved B-box domains. They serve as central regulators in plant photomorphogenesis and developmental processes. Accumulating genetic and biochemical evidence demonstrates that BBX family members orchestrate plant responses to biotic and abiotic stresses through multifaceted molecular mechanisms, including the regulation of reactive oxygen species (ROS) homeostasis, enhancement of… More >

Ioannis A. Voutsadakis^1,2,3,*

Oncology Research, Vol.33, No.12, pp. 4073-4092, 2025, DOI:10.32604/or.2025.069230 - 27 November 2025

Abstract Background: E26 transformation-specific (ETS) family transcription factors have confirmed roles in several types of cancers. This study aimed to clarify the role of ETS family transcription factor alterations in gastric cancers. Methods: This study examines molecular alterations of ETS transcription factors in gastric adenocarcinomas based on an analysis of publicly available cohorts from the Protein Atlas and the Cancer Genome Atlas. The expression and relationships of members of the ETS transcription factor family with other important factors in the process of gastric carcinogenesis were evaluated using the same resources. Results: mRNA expression levels of ETS family… More >

Luyao Sun^#, Ronghao Zhang^#, Kexin Su, Mengjie Wang, Kai Wang, Xiaoyu Wang^*

BIOCELL, Vol.49, No.11, pp. 2217-2237, 2025, DOI:10.32604/biocell.2025.068450 - 24 November 2025

Abstract Objectives: An allergy is an exaggerated immune response, and mast cells play central roles in allergic pathologies. Allyl isothiocyanate can suppress inflammatory responses; however, whether allyl isothiocyanate has a suppressive effect on allergic pathologies remains unclear. Methods: 2,4-dinitrofluorobenzen or ovalbumin was used to establish a mouse model of allergic contact dermatitis or food allergy, respectively. The mRNA level of cytokines was determined using real-time polymerase chain reaction. To examine the effects of allyl isothiocyanate on mast cells, degranulation and intracellular calcium measurement, RNA sequencing, real-time polymerase chain reaction, and Western blotting were performed. Results: Allyl isothiocyanate… More >

Zhong Ren^1,2,3,#, Shuiming Zhang^1,#, Yuzhi Fei¹, Zhu Chen³, Yue Zhao³, Xin Meng³, Hongfei Zhao^2,*, Jie Ren^3,*

Phyton-International Journal of Experimental Botany, Vol.94, No.9, pp. 2927-2947, 2025, DOI:10.32604/phyton.2025.067310 - 30 September 2025

Abstract Acer paxii belongs to the evergreen species of Acer, but it exhibits a unique feature of reddish leaves in fall in subtropical regions. Although the association of AP2/ERF transcription factors with color change has been well-documented in prior research, molecular investigations focusing on AP2/ERF remain notably lacking in Acer paxii. This research focuses on performing an extensive genome-wide investigation to identify and characterize the AP2/ERF gene family in Acer paxii. As a result, 123 ApAP2/ERFs were obtained. Phylogenetic analyses categorized the ApAP2/ERF family members into 15 subfamilies. The evolutionary traits of the ApAP2/ERFs were investigated by analyzing their… More >

Jianwei Wang^1,2, Xinzhi Yang³, Lvbiao Lin⁴, Jianbo Yu^5,*, Jie Mao^4,*

Oncology Research, Vol.33, No.10, pp. 3023-3040, 2025, DOI:10.32604/or.2025.065380 - 26 September 2025

Abstract Objectives: Glioma, as the most lethal primary brain malignancy with poor prognosis, requires further elucidation on the functional role of long noncoding RNA (lncRNA) DDX11 antisense RNA 1 (DDX11-AS1) in its pathogenesis, despite its established oncogenic functions in other cancers. Therefore, this study sought to characterize the oncogenic role and molecular mechanism of DDX11-AS1 in glioma. Methods: DDX11-AS1 expression levels were analyzed in clinical surgical glioma specimens and publicly available datasets. The functional roles of DDX11-AS1 on glioma cell proliferation and migration were investigated using in vitro knockdown and overexpression assays. In vivo tumor growth was assessed… More > Graphic Abstract

Imene Tatar Caliskan^1,2, George Dzorgbenya Ametefe³, Aziz Caliskan⁴, Su-Ee Lau^1,5, Yvonne Jing Mei Liew⁶, Nur Kusaira Khairul Ikram⁵, Boon Chin Tan^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.8, pp. 2229-2254, 2025, DOI:10.32604/phyton.2025.067225 - 29 August 2025

Abstract Myeloblastosis (MYB) transcription factors (TFs) are evolutionarily conserved regulatory proteins that are crucial for plant growth, development, secondary metabolism, and stress adaptation. Recent studies have highlighted their crucial role in coordinating growth–defense trade-offs through transcriptional regulation of key biosynthetic and stress-response genes. Despite extensive functional characterization in model plants such as Arabidopsis thaliana, systematically evaluating the broader functional landscape of MYB TFs across diverse species and contexts remains necessary. This systematic review integrates results from 24 peer-reviewed studies sourced from Scopus and Web of Science, focusing on the functional diversity of MYB TFs, particularly in relation… More >