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Search Results (31)
  • Open Access

    ARTICLE

    CARD11 serves as a therapeutic biomarker for the drug therapies of ccRCC

    KAIWEN TIAN#, HANZHONG CHEN#, QIANQIAN WANG, FENGLIAN JIANG, CHUNXIANG FENG, TENG LI, XIAOYONG PU, YANLIN TANG*, JIUMIN LIU*

    BIOCELL, Vol.48, No.5, pp. 817-834, 2024, DOI:10.32604/biocell.2024.048737

    Abstract Background: The incidence of clear cell renal cell carcinoma (ccRCC) is globally high; however, despite the introduction of innovative drug therapies, there remains a lack of effective biomarkers for evaluating treatment response. Recently, Caspase recruiting domain-containing protein 11 (CARD11) has garnered attention due to its significant association with tumor development and the immune system. Methods: The expression of CARD11 mRNA and protein in ccRCC were analyzed by public database and immunohistochemistry. The focus of this study is on the epigenomic modifications of CARD11, its expression of ccRCC immunophenotype, and its correlation with response to immunotherapy… More > Graphic Abstract

    CARD11 serves as a therapeutic biomarker for the drug therapies of ccRCC

  • Open Access

    REVIEW

    Clinical implications of single cell sequencing for bladder cancer

    REZA YADOLLAHVANDMIANDOAB1,#, MEHRSA JALALIZADEH1,#, FRANCIELE APARECIDA VECHIA DIONATO1, KEINI BUOSI1, PATRÍCIA A. F. LEME1, LUCIANA S. B. DAL COL1, CRISTIANE F. GIACOMELLI1, ALEX DIAS ASSIS1, NASIM BASHIRICHELKASARI1, LEONARDO OLIVEIRA REIS1,2,*

    Oncology Research, Vol.32, No.4, pp. 597-605, 2024, DOI:10.32604/or.2024.045442

    Abstract Bladder cancer (BC) is the 10th most common cancer worldwide, with about 0.5 million reported new cases and about 0.2 million deaths per year. In this scoping review, we summarize the current evidence regarding the clinical implications of single-cell sequencing for bladder cancer based on PRISMA guidelines. We searched PubMed, CENTRAL, Embase, and supplemented with manual searches through the Scopus, and Web of Science for published studies until February 2023. We included original studies that used at least one single-cell technology to study bladder cancer. Forty-one publications were included in the review. Twenty-nine studies showed… More > Graphic Abstract

    Clinical implications of single cell sequencing for bladder cancer

  • Open Access

    REVIEW

    LncRNAs unraveling their sponge role in glioblastoma and potential therapeutic applications

    CAIJUAN LIU, XINGHAO LI, YUXUAN WU, JINHUI YANG, MENGHAN WANG, YUNQI MA*

    BIOCELL, Vol.48, No.3, pp. 387-401, 2024, DOI:10.32604/biocell.2024.048791

    Abstract Glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor in adults, is the most malignant and still has no cure. However, the novel role of long non-coding RNAs (lncRNAs) in the pathogenesis of glioblastoma is attracting extensive attention. LncRNAs are transcribed RNA molecules over 200 nucleotides long that do not encode proteins. Unlike small non-coding RNAs, such as microRNAs (miRNAs), lncRNAs have more complex secondary and tertiary structures that enable them to interact with DNA, RNA, and proteins and perform multiple regulatory functions. LncRNAs act as molecular sponges, absorbing and sequestering other biomolecules,… More > Graphic Abstract

    LncRNAs unraveling their sponge role in glioblastoma and potential therapeutic applications

  • Open Access

    ARTICLE

    A novel oxaliplatin-resistant gene signatures predicting survival of patients in colorectal cancer

    QIOU GU1, CHUILIN LAI1, XIAO GUAN1, JING ZHU2, TIAN ZHAN1, JIANPING ZHANG1,*

    BIOCELL, Vol.48, No.2, pp. 253-269, 2024, DOI:10.32604/biocell.2023.028336

    Abstract Objectives: Colorectal cancer (CRC) is a serious threat to human health worldwide. Oxaliplatin is a platinum analog and is widely used to treat CRC. However, resistance to oxaliplatin restricts its effectiveness and application while its target recognition and mechanism of action also remain unclear. Therefore, we aimed to develop an oxaliplatin-resistant prognostic model to clarify these aspects. Methods: We first obtained oxaliplatin-resistant and parental cell lines, and identified oxaliplatin-resistant genes using RNA sequencing (RNA-seq) and differential gene analysis. We then acquired relevant data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases.… More > Graphic Abstract

    A novel oxaliplatin-resistant gene signatures predicting survival of patients in colorectal cancer

  • Open Access

    ARTICLE

    Glycogen metabolism-mediated intercellular communication in the tumor microenvironment influences liver cancer prognosis

    YANG ZHANG1,2,#, NANNAN QIN5,#, XIJUN WANG6,#, RUI LIANG7, QUAN LIU4, RUOYI GENG8, TIANXIAO JIANG8, YUNFEI LIU8,*, JINWEI LI3,4,*

    Oncology Research, Vol.32, No.3, pp. 563-576, 2024, DOI:10.32604/or.2023.029697

    Abstract Glycogen metabolism plays a key role in the development of hepatocellular carcinoma (HCC), but the function of glycogen metabolism genes in the tumor microenvironment (TME) is still to be elucidated. Single-cell RNA-seq data were obtained from ten HCC tumor samples totaling 64,545 cells, and 65 glycogen metabolism genes were analyzed by a nonnegative matrix factorization (NMF). The prognosis and immune response of new glycogen TME cell clusters were predicted by using HCC and immunotherapy cohorts from public databases. HCC single-cell analysis was divided into fibroblasts, NT T cells, macrophages, endothelial cells, and B cells, which… More >

  • Open Access

    ARTICLE

    NAD+ associated genes as potential biomarkers for predicting the prognosis of gastric cancer

    XIANGDONG SUN1,2,#, HUIJUAN WEN1,2,#, FAZHAN LI1,2, IHTISHAM BUKHARI1,2, FEIFEI REN1,2, XIA XUE1,2, PENGYUAN ZHENG1,2,*, YANG MI1,2,*

    Oncology Research, Vol.32, No.2, pp. 283-296, 2024, DOI:10.32604/or.2023.044618

    Abstract Nicotinamide adenine dinucleotide (NAD+) plays an essential role in cellular metabolism, mitochondrial homeostasis, inflammation, and senescence. However, the role of NAD+-regulated genes, including coding and long non-coding genes in cancer development is poorly understood. We constructed a prediction model based on the expression level of NAD+ metabolism-related genes (NMRGs). Furthermore, we validated the expression of NMRGs in gastric cancer (GC) tissues and cell lines; additionally, β-nicotinamide mononucleotide (NMN), a precursor of NAD+, was used to treat the GC cell lines to analyze its effects on the expression level of NMRGs lncRNAs and cellular proliferation, cell… More > Graphic Abstract

    NAD+ associated genes as potential biomarkers for predicting the prognosis of gastric cancer

  • Open Access

    ARTICLE

    Analysis of functional hub genes indicates DLGAP5 is linked to lung adenocarcinoma prognosis

    HAOSHENG ZHENG1,#, RUIJUN LIN2,#, WEIJIE CAI1, YUZHEN ZHENG1, XINGPING YANG1, ZUI LIU1, FEI QIN1, YONGJIE CAI3, XIANYU QIN1,*, HONGYING LIAO1,*

    BIOCELL, Vol.47, No.11, pp. 2453-2469, 2023, DOI:10.32604/biocell.2023.030032

    Abstract Introduction: The difficulty in treating lung adenocarcinoma (LUAD) is caused by a shortage of knowledge about the biological mechanisms and a lack of treatment choices. Objectives: The aim of this study was to identify a valuable molecular target for the treatment of LUAD. Methods: Using multiple databases, we screened for hub genes in LUAD using Cytoscape and explored the expression and prognosis of DLG associated protein 5 (DLGAP5) in LUAD. We investigated the genetic variation, functional enrichment, and epigenetic activity of DLGAP5. Furthermore, we evaluated the relationship between the tumor microenvironment (TME) and DLGAP5. Results: Our… More > Graphic Abstract

    Analysis of functional hub genes indicates DLGAP5 is linked to lung adenocarcinoma prognosis

  • Open Access

    EDITORIAL

    Editorial: Transcriptome analysis in tumor microenvironment and tumor heterogeneity

    JINHUI LIU1,*, JIAHENG XIE2,*, PEIXIN DONG3

    Oncology Research, Vol.32, No.1, pp. 99-100, 2024, DOI:10.32604/or.2023.045719

    Abstract This article has no abstract. More >

  • Open Access

    REVIEW

    New perspectives on biology, disease progression, and therapy response of head and neck cancer gained from single cell RNA sequencing and spatial transcriptomics

    GERWIN HELLER1,*, THORSTEN FUEREDER1, ALEXANDER MICHAEL GRANDITS1, ROTRAUD WIESER1,2,*

    Oncology Research, Vol.32, No.1, pp. 1-17, 2024, DOI:10.32604/or.2023.044774

    Abstract Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent cancers worldwide. The main risk factors are consumption of tobacco products and alcohol, as well as infection with human papilloma virus. Approved therapeutic options comprise surgery, radiation, chemotherapy, targeted therapy through epidermal growth factor receptor inhibition, and immunotherapy, but outcome has remained unsatisfactory due to recurrence rates of ~50% and the frequent occurrence of second primaries. The availability of the human genome sequence at the beginning of the millennium heralded the omics era, in which rapid technological progress has advanced our knowledge… More >

  • Open Access

    ARTICLE

    TonEBP expression is essential in the IL-1β–induced migration and invasion of human A549 lung cancer cells

    HEE JU SONG, TAEHEE KIM, HAN NA CHOI, SOO JIN KIM, SANG DO LEE*

    Oncology Research, Vol.32, No.1, pp. 151-161, 2024, DOI:10.32604/or.2023.030690

    Abstract Lung cancer has the highest mortality rate among all cancers, in part because it readily metastasizes. The tumor microenvironment, comprising blood vessels, fibroblasts, immune cells, and macrophages [including tumor-associated macrophages (TAMs)], is closely related to cancer cell growth, migration, and invasion. TAMs secrete several cytokines, including interleukin (IL)-1β, which participate in cancer migration and invasion. p21-activated kinase 1 (PAK1), an important signaling molecule, induces cell migration and invasion in several carcinomas. Tonicity-responsive enhancer-binding protein (TonEBP) is also known to participate in cancer cell growth, migration, and invasion. However, the mechanisms by which it increases lung… More > Graphic Abstract

    TonEBP expression is essential in the IL-1β–induced migration and invasion of human A549 lung cancer cells

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