Norbert Nass^1,2,#, Mohamad-Kamal Yaakoub^1,#, Alexandra-Victorita Simion³, Hartmut Kroll⁴, Sabine Westphal³, Judith Pannier¹, Gerhard Behre^1,*

Oncology Research, Vol.33, No.10, pp. 2923-2935, 2025, DOI:10.32604/or.2025.067561 - 26 September 2025

Abstract Background: Patients with hemato-oncological malignancies may respond insufficiently to vaccination, especially in terms of antibody titer. The antibody response depends on the type of malignancy as well as the type and timing of treatment. We intended to evaluate this using real-world data from patients of our regional hospital. This study also considers the role of immune status, including T-cell activation markers, in predicting vaccination success. Methods: Seventeen patients of our hospital having a hematological malignancy were included in this study, including myeloma, lymphoma, as well as acute myeloid leukemia (AML) and chronic lymphoid leukemia (CLL).… More >

VERA RUZANOVA¹, ANASTASIA PROSKURINA¹, GENRIKH RITTER¹, EVGENIYA DOLGOVA¹, SOFYA OSHIKHMINA^1,2, SVETLANA KIRIKOVICH¹, EVGENIY LEVITES¹, YAROSLAV EFREMOV^2,3, OLEG TARANOV⁴, ALEXANDR OSTANIN⁵, ELENA CHERNYKH⁵, NIKOLAY KOLCHANOV⁶, SERGEY BOGACHEV^1,*

Oncology Research, Vol.33, No.5, pp. 1229-1248, 2025, DOI:10.32604/or.2025.059411 - 18 April 2025

Abstract Objectives: Currently, there exist two approaches to the treatment of malignant neoplasms: the Karanahan technology and in situ vaccination, which are based on chronometric delivery of therapeutic agents to the tumor depending on the characteristics of tumor cells, as well as the immune status. The main purpose of this study was to experimentally prove the feasibility of combining the Karanahan technology and in situ vaccination with αOX40 antibodies into a single therapeutic platform to achieve a potent additive antitumor therapeutic effect. Methods: BALB/c mice grafted with B-cellular lymphoma A20 were treated using the Karanahan technology consisting of… More >

Shira Cohen Rubin^1,*, Nadav Zacks¹, Ori Wand², Ophir Freund³, Evgeni Gershman³, Anna Breslavsky², Rotem Givoli-Vilensky¹, Anat Tzurel Ferber², Natalya Bilenko^1,4, Amir Bar-Shai³

European Cytokine Network, Vol.35, No.1, pp. 13-19, 2024, DOI:10.1684/ecn.2024.0494 - 05 January 2026

Abstract COVID-19 vaccination and acute infection result in cellular and humoral immune responses with various degrees of protection. While most studies have addressed the difference in humoral response between vaccination and acute infection, studies on the cellular response are scarce. We aimed to evaluate differences in immune response among vaccinated patients versus those who had recovered from COVID-19. Materials and Methods: This was a prospective study in a tertiary medical centre. The vaccinated group included health care workers, who had received a second dose of the BNT162b2 vaccine 30 days ago. The recovered group included adults… More >

Muhammad Altaf Khan^1,*, Mahmoud H. DarAssi², Irfan Ahmad³, Noha Mohammad Seyam⁴, Ebraheem Alzahrani⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.141, No.2, pp. 1365-1394, 2024, DOI:10.32604/cmes.2024.053681 - 27 September 2024

Abstract A mathematical model is designed to investigate Tuberculosis (TB) disease under the vaccination, treatment, and environmental impact with real cases. First, we introduce the model formulation in non-integer order derivative and then, extend the model into fractional order derivative. The fractional system’s existence, uniqueness, and other relevant properties are shown. Then, we study the stability analysis of the equilibrium points. The disease-free equilibrium (DFE) is locally asymptotically stable (LAS) when . Further, we show the global asymptotical stability (GAS) of the endemic equilibrium (EE) for and for . The existence of bifurcation analysis in the More >

Ibtehal Alazman¹, Kholoud Saad Albalawi¹, Pranay Goswami^2,*, Kuldeep Malik²

CMES-Computer Modeling in Engineering & Sciences, Vol.137, No.3, pp. 2409-2425, 2023, DOI:10.32604/cmes.2023.028674 - 03 August 2023

Abstract This paper presents a restricted SIR mathematical model to analyze the evolution of a contagious infectious disease outbreak (COVID-19) using available data. The new model focuses on two main concepts: first, it can present multiple waves of the disease, and second, it analyzes how far an infection can be eradicated with the help of vaccination. The stability analysis of the equilibrium points for the suggested model is initially investigated by identifying the matching equilibrium points and examining their stability. The basic reproduction number is calculated, and the positivity of the solutions is established. Numerical simulations More >

Lakhlifa Sadek¹, Otmane Sadek¹, Hamad Talibi Alaoui², Mohammed S. Abdo³, Kamal Shah^4,5, Thabet Abdeljawad^4,6,*

CMES-Computer Modeling in Engineering & Sciences, Vol.136, No.2, pp. 1931-1950, 2023, DOI:10.32604/cmes.2023.025033 - 06 February 2023

Abstract In this work, we present a model that uses the fractional order Caputo derivative for the novel Coronavirus disease 2019 (COVID-19) with different hospitalization strategies for severe and mild cases and incorporate an awareness program. We generalize the SEIR model of the spread of COVID-19 with a private focus on the transmissibility of people who are aware of the disease and follow preventative health measures and people who are ignorant of the disease and do not follow preventive health measures. Moreover, individuals with severe, mild symptoms and asymptomatically infected are also considered. The basic reproduction… More >

Abeer S. Alnahdi^1,*, Mdi B. Jeelani¹, Hanan A. Wahash², Mansour A. Abdulwasaa^3,4

CMES-Computer Modeling in Engineering & Sciences, Vol.135, No.2, pp. 1315-1343, 2023, DOI:10.32604/cmes.2022.023694 - 27 October 2022

Abstract This study aims to structure and evaluate a new COVID-19 model which predicts vaccination effect in the Kingdom of Saudi Arabia (KSA) under Atangana-Baleanu-Caputo (ABC) fractional derivatives. On the statistical aspect, we analyze the collected statistical data of fully vaccinated people from June 01, 2021, to February 15, 2022. Then we apply the Eviews program to find the best model for predicting the vaccination against this pandemic, based on daily series data from February 16, 2022, to April 15, 2022. The results of data analysis show that the appropriate model is autoregressive integrated moving average… More >

Badriya Murdhi Alenzi, Muhammad Badruddin Khan, Mozaherul Hoque Abul Hasanat, Abdul Khader Jilani Saudagar^*, Mohammed AlKhathami, Abdullah AlTameem

Intelligent Automation & Soft Computing, Vol.34, No.2, pp. 1311-1331, 2022, DOI:10.32604/iasc.2022.025861 - 03 May 2022

Abstract With the recent boom in the corpus size of sentiment analysis tasks, automatic annotation is poised to be a necessary alternative to manual annotation for generating ground truth dataset labels. This article aims to investigate and validate the performance of two widely used lexicon-based automatic annotation approaches, TextBlob and Valence Aware Dictionary and Sentiment Reasoner (VADER), by comparing them with manual annotation. The dataset of 5402 Arabic tweets was annotated manually, containing 3124 positive tweets, 1463 negative tweets, and 815 neutral tweets. The tweets were translated into English so that TextBlob and VADER could be More >

Phi-Hung Nguyen^1,2,*

CMC-Computers, Materials & Continua, Vol.72, No.3, pp. 5059-5078, 2022, DOI:10.32604/cmc.2022.027630 - 21 April 2022

Abstract The main objective of this study is to comprehensively investigate individuals’ vaccination intention against COVID-19 during the second wave of COVID-19 spread in Vietnam using a novel hybrid approach. First, the Decision-Making Trial and Evaluation Laboratory based on Grey Theory (DEMATEL-G) was employed to explore the critical factors of vaccination intention among individuals. Second, Partial Least Squares-Structural Equation Modeling (PLS-SEM) was applied to test the hypotheses of individual behavioral intention to get the vaccine to prevent the outbreak of COVID-19. A panel of 661 valid respondents was collected from June 2021 to July 2021, and… More >

FEI CHEN^1,*, CHUN LUAN¹, ZICHUN WEI¹, DECHEN CAI¹, ZHIWEN CUI¹, YUYANG LI¹, HAO WU², XIAOXIA ZHANG¹, XIAOLI WU²

BIOCELL, Vol.46, No.6, pp. 1425-1433, 2022, DOI:10.32604/biocell.2022.019868 - 07 February 2022

Abstract The coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has posed a potential threat to infant health. The World Health Organization recommended that the benefits of breastfeeding far outweigh the potential risk of transmission, but there is no denying that the current evidence is insufficient. Moreover, although the COVID-19 mRNA vaccine has played an effective role in protection against infection, individuals have increasing concerns about the safety of breastfeeding after vaccination, and which have caused some breastfeeding women to postpone vaccination or stop breastfeeding early. Thus, in this… More >