JIAN TANG¹, CHENQIANG ZHU¹, YUN CHEN¹, YUNLONG WU¹, MING HE¹, YI ZHOU², MINGHUA XIE^2,*

BIOCELL, Vol.48, No.4, pp. 639-651, 2024, DOI:10.32604/biocell.2024.047562

Abstract Background: The specific impact of sphingolipid metabolism on developing hepatocellular Carcinoma (HCC) remains unclear. This study aims to explore the relationship between sphingolipid metabolism and HCC prognosis, immune response, and drug sensitivity. Methods: Data were obtained from The Cancer Genome Atlas (TCGA)-Hepatocellular Carcinoma (LIHC) and Gene Expression Omnibus (GEO, GSE14520 datasets). 47 sphingolipid metabolism genes were obtained from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. After classifying HCC samples using the Non-negative Matrix Factorization (NMF) clustering method, differentially expressed genes were screened. Then, 8 risk genes were obtained by univariate analysis, survival random forest reduction and lasso analysis.… More > Graphic Abstract

Thomas Leduc, Xenia Stavropulos-Laffaille, Ignacio Requena-Ruiz

Revue Internationale de Géomatique, Vol.31, No.2, pp. 241-263, 2022, DOI:10.3166/RIG.31.241-263©2022

Abstract The adaptation of public spaces to episodes of intense heat is now a major challenge for cities. With this in mind, this article presents a contribution aimed at delineating and handling the shadows on the ground or in a horizontal plane at a given height, whether it comes from buildings, street furniture or the tree cover. After a comparison with shadows obtained via two reference tools, we present two urban sites that mix shadows of different origins and, in addition, different indicators. The results of the simulations are compared with pyranometric surveys carried out on site. The aim of these… More >

YANAN MA¹, SHANSHAN WANG^2,*, HUIGUO DING^1,*

BIOCELL, Vol.48, No.3, pp. 463-471, 2024, DOI:10.32604/biocell.2024.048244

Abstract Background: Hepatocellular carcinoma (HCC) is a common malignant tumor with poor prognosis and high mortality worldwide. Although cystathionine-gamma-lyase (CSE) plays an important role in the development of multiple tumors, the clinical implication and potential mechanisms of CSE in HCC development remain elusive. Methods: In our study, the CSE expression in HCC was analyzed in Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) datasets and further confirmed by RT-qPCR and immunohistochemistry assays in HCC samples. Furthermore, the associations between CSE expression and HCC malignancy as well as survival were analyzed in GSE14520 and validated in HCC patients. Finally, the… More >

Chili Li¹, Xinxin Zhao², Ziwen Pan³, Ting Yi⁴, Long Qian^5,6,*

International Journal of Mental Health Promotion, Vol.26, No.2, pp. 161-175, 2024, DOI:10.32604/ijmhp.2023.029896

Abstract While a plethora of studies has been conducted to explore demotivation and its impact on mental health in second language (L2) education, scanty research focuses on demotivation in L2 speaking learning. Particularly, little research explores the measures to quantify L2 speaking demotivation. The present two-phase study attempts to develop and validate an English Speaking Demotivation Scale (ESDS). To this end, an independent sample of 207 Chinese tertiary learners of English as a Foreign Language (EFL) participated in the development phase, and another group of 188 Chinese EFL learners was recruited for the validation of the scale. Exploratory Factor Analysis (EFA)… More >

Siyuan Bi¹, Junfeng Yuan^1,2, Lin Luo^1,2,3,*

International Journal of Mental Health Promotion, Vol.26, No.1, pp. 51-60, 2024, DOI:10.32604/ijmhp.2023.041614

Abstract Purpose: The core component theory of addiction behavior provides a multidimensional theoretical model for measuring social networking addiction. Based on this theoretical model, the Social Networking Addiction Scale (SNAS) was developed. The aim of this study was to test the psychometric properties of the Chinese version of the SNAS (SNAS-C). Methods: This study used a sample of 3383 Chinese university students to conduct confirmatory factor analysis (CFA) to explore the structural validity of the SNAS-C. This study examined the Pearson correlations between the six subscales of the SNAS-C (i.e., salience, mood modification, tolerance, withdrawal symptoms, conflict, and relapse) and “social… More >

HENG ZHANG^1,#, WENJING CHENG^2,#, HAIBO ZHAO², WEIDONG CHEN², QIUJIE ZHANG^2,*, QING-QING YU^2,*

Oncology Research, Vol.32, No.2, pp. 297-308, 2024, DOI:10.32604/or.2023.043138

Abstract Background: Colorectal cancer (CRC) belongs to the class of significantly malignant tumors found in humans. Recently, dysregulated fatty acid metabolism (FAM) has been a topic of attention due to its modulation in cancer, specifically CRC. However, the regulatory FAM pathways in CRC require comprehensive elucidation. Methods: The clinical and gene expression data of 175 fatty acid metabolic genes (FAMGs) linked with colon adenocarcinoma (COAD) and normal cornerstone genes were gathered through The Cancer Genome Atlas (TCGA)-COAD corroborating with the Molecular Signature Database v7.2 (MSigDB). Initially, crucial prognostic genes were selected by uni- and multi-variate Cox proportional regression analyses; then, depending… More >

ZEPENG DONG, CHENYE ZHAO, SHIBO HU, KUI YANG, JUNHUI YU^*, XUEJUN SUN, JIANBAO ZHENG^*

BIOCELL, Vol.47, No.12, pp. 2735-2745, 2023, DOI:10.32604/biocell.2023.043422

Abstract Objectives: Angiogenesis plays a significant role in the occurrence and development of inflammatory bowel disease (IBD). The aim of this study is to explore potential angiogenesis related genes (ARGs) in IBD through bioinformatics analysis and in vivo experiments. Methods: GSE57945, GSE87466, and GSE36807 were obtained from the Gene Expression Omnibus database. GSE57945 was used as the training set, while GSE87466 and GSE36807 were used as the validation set. The key ARGs associated with IBD were identified using the least absolute shrinkage and selection operator (LASSO) and random forest methods. These identified ARGs were then utilized to construct a diagnostic model… More >

Yaping Luo¹, Na Guo^1,*, Dong Liu², Shuming Peng³, Xinchen Wang⁴, Jie Wu³

Revue Internationale de Géomatique, Vol.32, pp. 39-52, 2023, DOI:10.32604/RIG.2023.046014

Abstract Using hyperspectral data collected in January and June 2022 from the Sha River, the concentrations of total nitrogen (TN) and total phosphorus (TP) were estimated using the differential method. The results indicate that the optimal bands for estimation vary monthly due to temperature fluctuations. In the TN model, the power function model at 586 nm in January exhibited the strongest fit, yielding a fit coefficient (R²) of 0.95 and F-value of 164.57 at a significance level (p) of less than 0.01. Conversely, the exponential model at 477 nm in June provided the best fit, with R² = 0.93 and F… More > Graphic Abstract

Biswajit De^*, Rajsekhar Panua

Frontiers in Heat and Mass Transfer, Vol.5, pp. 1-6, 2014, DOI:10.5098/hmt.5.7

Abstract This paper presents a pre-mixed combustion model for diesel and Jatropha oil blends combustion studies. Jatropha oil blends are considered as a mixture of diesel and Jatropha oil. CFD package, FLUENT 6.3 is used for modeling the complex combustion phenomenon in compression ignition engine. The experiments are carried out on a single cylinder, four strokes, water cooled direct injection compression ignition engine at compression ratio of 17.5 at full load condition at constant speed of 1500 rpm fuelled with diesel and jatropha oil blends with diesel. The numerical model is solved by considering pressure based, implicit and unsteady solver and… More >

Biswajit De^*, Rajsekhar Panua

Frontiers in Heat and Mass Transfer, Vol.6, pp. 1-6, 2015, DOI:10.5098/hmt.6.11

Abstract An incorporated arithmetical model has been urbanized and investigated for CFD replication of a solitary cylinder, four stroke, straight inoculation, compressed ignition diesel engine of 3.5 kW for in-cylinder combustion analysis and authenticated under engine simulations at full load functioning conditions with foundation fuel diesel and 10% JME (volume basis) blend with diesel at invariable speed of 1500 rpm. For advancing the exactness of the exertion, a number of sub models, such as species transport model explaining the actual biodiesel energy content and molecular structure as soon as fuel blend is initiated, spray break-up model, wave model and pre-mixed combustion… More >