NARAYANAN NAMPOOTHIRI V. P.¹, VIGNESH SUNDARARAJAN¹, PALLAVI DAN¹, G. DEVANAND VENKATASUBBU^2,*, SAHABUDEEN SHEIK MOHIDEEN^1,*

BIOCELL, Vol., , DOI:10.32604/biocell.2021.015090

Abstract Alzheimer’s disease (AD) is one of the most common forms of dementia. Cognitive dysfunction and memory loss are the two main clinical symptoms of AD. Drosophila melanogaster models of AD, which are based on overexpression of human amyloid β (Aβ) or human tau (hTau) protein, have been used to study the mechanism underlying AD and to screen potential therapeutic compounds. Drugs that are currently available for AD provide only symptomatic relief. Huge unmet medical needs exists to slow, stop, or reverse the progression of AD. Thymoquinone (TQ) is an active ingredient isolated from Nigella sativa (NS) and possesses various pharmacological… More >

CHEN-LIANG TSAI¹, YU-HUEI LIN², CHIH-YING CHANGCHIEN³, CHIH-FENG CHIAN^1,#,*, CHI-HUEI CHIANG^4,#,*

BIOCELL, Vol., , DOI:10.32604/biocell.2021.014279

Abstract Primary lung graft dysfunction could significantly attribute to ischemia-reperfusion lung injury (IRLI) during transplantation surgery. β2-adrenergic agonists were one of the bronchodilators that had been well-established in the management of asthma and chronic obstructive pulmonary disease (COPD) with anti-inflammatory potency. By applying the model of isolated rat lung, we evaluated the efficacy of short-acting β2-agonist inhalation to ameliorate ischemia-reperfusion damage. The experiment protocol was 180 min of global ischemia and then reperfusion for 60 min. In the β2-agonist inhalation group, aerosolized albuterol was administrated prior ischemia procedure. Increased weight ratios of wet to dry lung and microvascular permeability were characterized… More >

ALAA OMRAN ALMAGRABI¹, YASER DAANIAL KHAN², SHER AFZAL KHAN^3,*

BIOCELL, Vol., , DOI:10.32604/biocell.2021.013770

Abstract Phosphoaspartate is one of the major components of eukaryotes and prokaryotic two-component signaling pathways, and it communicates the signal from the sensor of histidine kinase, through the response regulator, to the DNA alongside transcription features and initiates the transcription of correct response genes. Thus, the prediction of phosphoaspartate sites is critical, and its experimental identification can be expensive, time-consuming, and tedious. For this purpose, we propose iPhosD-PseAAC, a new computational model for predicting phosphoaspartate sites in a particular protein sequence using Chou’s 5-steps rues: (1) Benchmark dataset. (2) The feature extraction techniques such as pseudo amino acid composition (PseAAC), statistical… More >

Ling Wang^1,2, Chenchen Huang¹, Ping Zhang³, Fenghua Liu^1,*, Ting Zou¹, Zhixiang Li¹, Jianfei Zhang¹, Gaojie Xu¹

Journal of Renewable Materials, Vol., , DOI:10.32604/jrm.2021.013884

Abstract Using palygorskite (PAL) as template, the PAL/TiO₂/PANI nano-rods were synthesized by heterogeneous precipitation and in-situ polymerization. The synthesized PAL/TiO₂/PANI nanorods were used as a novel electrorheological (ER) fluid by mixing with silicone oil, which showed excellent ER effect. The yield stress of the PAL/TiO₂/PANI based ER fluid (15 vol%) reached 8.8 kPa under 4 kV mm⁻¹ electric field. The dynamic shear stress of the PAL/TiO₂/PANI based ER fluid could maintain a stable level in the shear rate range of 0.1–100 s⁻¹ . Furthermore, the PAL/TiO₂/PANI ER fluid exhibited excellent suspension stability. More >

P. Veeresha¹, Esin Ilhan², D. G. Prakasha³, Haci Mehmet Baskonus⁴, Wei Gao^5,*

CMES-Computer Modeling in Engineering & Sciences, Vol., , DOI:10.32604/cmes.2021.014988

Abstract In this paper, we analyze the behaviour of solution for the system exemplifying model of tumour invasion and metastasis by the help of q-homotopy analysis transform method (q-HATM) with the fractional operator. The analyzed model consists of a system of three nonlinear differential equations elucidating the activation and the migratory response of the degradation of the matrix, tumour cells and production of degradative enzymes by the tumour cells. The considered method is graceful amalgamations of q-homotopy analysis technique with Laplace transform (LT), and Caputo–Fabrizio (CF) fractional operator is hired in the present study. By using the fixed point theory, existence… More >

Yinhe Bu¹, Xingping Zhang^1,2,3,*

Energy Engineering, Vol., , DOI:10.32604/EE.2021.015893

Abstract With the explosive growth of variable renewable energy, the balance between the supply and demand of the power grid is faced with new challenges. Based on the development experience from typical countries and the state quo in China, this paper further analyzes the system architecture and development trend of demand response under the background of Energy Internet. Five dimensions are considered: Energy Internet platform, demand response application scenarios, system architecture, information technology system construction, and demand response development trend. The results show that the application of the Energy Internet platform can effectively solve the problems of data acquisition and processing,… More >

Huiwen Xu^*, Zhen Wang

Energy Engineering, Vol., , DOI:10.32604/EE.2021.015028

Abstract In recent years, China has developed rapidly in terms of natural gas. Driven by regional economic integration, a regional natural gas market composed of neighboring provinces and cities has taken shape gradually, and it tends to grow toward the same direction in policy formulation, resource coordination, facility construction and market expansion. Based on the factors such as geographical location, economic conditions and natural gas consumption, this thesis tends to conduct a horizontal comparative analysis on the economic development conditions, natural gas consumption characteristics and natural gas pipeline network density of the three regions with obvious regional integration feature in China.… More >

Heru Suryanto^1,2,*, Muhamad Muhajir¹, Bili Darnanto Susilo¹, Yanuar Rohmat Aji Pradana¹, Husni Wahyu Wijaya^2,3, Abu Saad Ansari⁴, Uun Yanuhar⁵

Journal of Renewable Materials, Vol., , DOI:10.32604/jrm.2021.015312

Abstract The microstructure of bacterial cellulose nanofibers (BCNs) film affects its characteristic. One of several means to engineer the microstructure is by changing the BCNs size and fiber distribution through a high-pressure homogenizer (HPH) process. This research aimed to find out the effects of repetition cycles on HPH process towards BCNs film characteristics. To prepare BCNs films, a pellicle from the fermentation of pineapple peels waste with Acetobacter xylinum (A. xylinum) was extracted, followed by crushing the pellicle with a high-speed blender, thereafter, homogenized using HPH at 150 bar pressure with variations of 5, 10, 15, and 20 cycles. The BCNs… More >

Dequan Guo¹, Qiao Yang², Yu-Dong Zhang³, Tao Jiang¹, Hanbing Yan^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol., , DOI:10.32604/cmes.2021.014119

Abstract The problem of domestic refuse is becoming more and more serious with the use of all kinds of equipment in medical institutions. This matter arouses people’s attention. Traditional artificial waste classification is subjective and cannot be put accurately; moreover, the working environment of sorting is poor and the efficiency is low. Therefore, automated and effective sorting is needed. In view of the current development of deep learning, it can provide a good auxiliary role for classification and realize automatic classification. In this paper, the ResNet-50 convolutional neural network based on the transfer learning method is applied to design the image… More >

Huinan Sun^1,*, Siqiang Wang², Zhuoqing Zhang¹, Chaoyong Xia¹, Xu Chen¹

CMES-Computer Modeling in Engineering & Sciences, Vol., , DOI:10.32604/cmes.2021.015791

Abstract Grains are widely present in industrial productions and processing, and are stored in silos. In the silo, auxiliary structures are added to achieve efficient production. However, little effort has been devoted to the influence of the internal structure of the silo on the granular flow. In this work, a silo with a central decompression tube is studied through experimental measurements and discrete element methods. Then, the influences of the central decompression tube on the flow behavior of grains and wall pressure are analyzed. Results show that the grains are in mass flow in the silo without a central decompression tube,… More >