Kerlin P. Robert¹, Jiaoyan Li², James D. Lee^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 74-74, 2019, DOI:10.32604/mcb.2019.07125

Abstract This presentation focuses on the new and upcoming concept of 4D printing and its vast scope and importance in the research and development in industry. The 3D printing object is considered as a layered structure. Each layer may have different orientation. Therefore each layer may behave differently under the change of its environment. We formulate the theoretical shape changing process of 4D printing resulted from (I) the biological growth or swelling, (II) the change of temperature, and (III) the effect of electric field on piezoelectric material of the 3D printing product. Then we illustrate this More >

Frederick H. Silver^1,*, Ruchit G. Shah², Dominick Benedetto³

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 73-73, 2019, DOI:10.32604/mcb.2019.08150

Abstract Previous literature reports suggest that tissue stiffness is a predictor of cancer and metastatic behavior of lesions. We have used optical coherence tomography and vibrational analysis (VOCT) to characterize normal skin, scar, a verrucous carcinoma (a squamous cell carcinoma subtype), a basal cell carcinoma and benign skin lesions non-invasively and non-destructively. The results suggest that epidermal thickening and increased keratin and basal cell production occur in malignant lesions and lead to increases in surface hills and valleys as well as subsequent increases in epidermal stiffness values. Increased stiffness of the epidermis is a result of… More >

Dominick Benedetto^1,*, Frederick H. Silver²

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 72-72, 2019, DOI:10.32604/mcb.2019.08149

Abstract Vibrational Optical Coherence Tomography (VOCT) is new technique capable of nondestructively measuring the biomechanical properties of ocular tissues in vivo. The technology utilizes audible sound combined with OCT imaging to obtain the resonant frequencies of both the cellular and extracellular components of tissue. The measured value of the resonant frequency is converted into a modulus using the tissue thickness, determined by OCT imaging, and a calibration curve of tissue modulus versus resonant frequency squared divided by sample thickness obtained from in vitro experiments. In this presentation we extend our analysis to ocular tissues specifically the… More >

Frederick H. Silver^1,*, Ruchit Shah²

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 71-71, 2019, DOI:10.32604/mcb.2019.08147

Abstract Vibrational Optical Coherence Tomography (VOCT) is new technique capable of noninvasively and nondestructively measuring the biomechanical properties of tissues in vivo. The technology utilizes audible sound combined with infra-red light applied transversely to the tissue surface to obtain the resonant frequencies of both the cellular and extracellular components of tissue. The measured value of the resonant frequency is related to the elastic modulus and the sample dimensions. The technique is calibrated by making in vitro measurements of the Young’s modulus using uniaxial tensile experiments on the same samples used to make VOCT measurements. In this presentation we… More >

Sitong Zhou¹, Jiandi Wan^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 70-70, 2019, DOI:10.32604/mcb.2019.06978

Abstract Piezo proteins (Piezo1 and Piezo2) are recently identified mechanically activated cation channels in eukaryotic cells and associated with physiological responses to touch, pressure, and stretch. In particular, human RBCs express Piezo1 on their membranes, and mutations of Piezo1 have been linked to hereditary xerocytosis. To date, however, physiological functions of Piezo1 on normal RBCs remain poorly understood. Here, we show that Piezo1 regulates mechanotransductive release of ATP from human RBCs by controlling the shear-induced Ca2+ influx [1]. We find that, in human RBCs treated with Piezo1 inhibitors or having mutant Piezo1 channels, the amounts of More >

Zhu Zeng^1,*, Zuquan Hu¹, Qinni Zheng¹, Xiaoli Xu¹, Rong Dong¹, Hui Xue¹, Hui Yang¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 68-69, 2019, DOI:10.32604/mcb.2019.07085

Abstract Dendritic cells (DCs) play a crucial role in initiating and amplifying both the innate and adaptive immune responses [1]. Clinically, the DCs-based immunotherapy against cancer is considered one of the most promising therapies to overcome cancers, but there are still many challenges need to be overcome [2]. The motility of DCs is especially crucial for migration of immature DCs into peripheral tissue and dynamic physical interaction between mature DCs and naive T cells in the secondary lymph node. This study focuses on the investigations of DCs at different differentiation stages and under various suppressive cytokines… More >

Wenhui Hu¹, Yun Wang¹, Jin Chen¹, Yonggang Song¹, Jinhua Long¹, Zhu Zeng^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 67-67, 2019, DOI:10.32604/mcb.2019.07083

Abstract The responses of dendritic cells (DCs) to the mechanical microenvironment caused by implanted materials are highly correlated to the host immune responses and largely determines the outcome of tissue regeneration [1,2]. In the early stage of the inflammations following injury or implantation, a large amount of fibrin would deposit around the implanted materials and form a microporous fibrous-liked network structure, which can provide mechanical microenvironment with different spatial confinement in dimensions for following recruited DCs. Herein, we have established a useful model by salmon fibrin to mimic the deposited fibrin matrix and found that DCs More >

Angran Li¹, Xiaoqi Chai², Ge Yang^2,3, Yongjie Jessica Zhang^1,2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 66-66, 2019, DOI:10.32604/mcb.2019.07633

Abstract Neurons exhibit remarkably complex geometry in their neurite networks. So far, how materials are transported in the complex geometry for survival and function of neurons remains an unanswered question. Answering this question is fundamental to understanding the physiology and disease of neurons. Here, we have developed an isogeometric analysis (IGA) based platform for material transport simulation in neurite networks. We modeled the transport process by reaction-diffusion-transport equations and represented geometry of the networks using truncated hierarchical tricubic B-splines (THB-spline3D). We solved the Navier-Stokes equations to obtain the velocity field of material transport in the networks. More >

Mingxing Ouyang^1,*, Zhili Qian¹, Yang Jin¹, Linhong Deng¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 65-65, 2019, DOI:10.32604/mcb.2019.06642

Abstract The collective functions at cell population level rely on cell-cell communications with or without direct contacts [1-3]. The long-range biomechanical force propagating across certain scales far beyond single cell size may reserve the capability to trigger coordinative biological responses within cell population [3-5]. Whether and how cells communicate with each other mechanically in a distant manner remains largely to be explored. Airway smooth muscle (ASM) cells are one crucial component in providing mechanical support and contraction force for the bronchial tubes in respiratory system, whereas the mechanical property of ASM is also associated with asthma… More >

Wei Sun^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 64-64, 2019, DOI:10.32604/mcb.2019.08533

Abstract Fluid–structure interaction (FSI) is a common phenomenon in biological systems. FSI problems of practical interest, such as fish/mammalian swimming, insect/bird flight, and human cardiac blood flow and respiration often involve multiple 3D immersed bodies with complex geometries undergoing very large structural displacements, and inducing very complex flow phenomena. Simulation of heart valve FSI is a technically challenging problem due to the large deformation of the valve leaflets through the cardiac fluid domain in the atrium and ventricular chambers.
Recently, we developed a FSI computational framework [1] for modeling patient-specific left heart (LH) dynamics using smoothed… More >