Jung-Il Chae^1,#, Ji-Hye Seo^1,#, Goo Yoon², Young-Joo Jeon^3,*, Woo-Keun Kim^4,*

BIOCELL, DOI:10.32604/biocell.2025.062137

Abstract Background: Picropodophllotoxin (PPT), a principal component of Podophyllum hexandrum root, demonstrates various beneficial biological activities in multiple cancer types, including antitumor and antiproliferative properties. Despite its known effects, the specific mechanisms by which PPT induces apoptosis in oral squamous cell carcinoma (OSCC) cells lack full clarification. Aims: This study aimed to evaluate the role of PPT in inducing apoptosis in OSCC cells by targeting signal transducer and activator of transcription 3 (STAT3) and to investigate the underlying molecular pathways. Methods: Human OSCC cell lines (HN22 and HSC4) were treated with PPT. Cell viability, colony formation, and apoptotic… More >

Gloria Krajnc¹, Lara Metlika², Uroš Potočnik^1,2,3, Boris Gole^2,*

BIOCELL, DOI:10.32604/biocell.2025.063486

Abstract Vedolizumab is a humanized monoclonal antibody and one of the safest biologics for the treatment of both forms of inflammatory bowel disease (IBD)-Crohn’s disease and ulcerative colitis. It targets the α4β7 integrin and blocks leukocyte trafficking to the gut. Regardless of its efficacy in many patients, non-response to vedolizumab treatment poses a significant clinical challenge. In this review, we synthesize recent findings on genomic, transcriptomic, proteomic, and cellular biomarkers of vedolizumab response, emphasizing their roles in predicting therapeutic outcomes and understanding non-responsiveness. Key insights include the identification of epigenetic and transcriptomic signatures, the involvement of More >

Zahra Alhawsa^*, Rewaa Jalal, Nouf Asiri

Phyton-International Journal of Experimental Botany, DOI:10.32604/phyton.2025.061918

Abstract Salinity stress is a major constraint on agricultural productivity, particularly in arid and semi-arid regions. This study evaluated the potential of Ascophyllum nodosum extract (ANE) in mitigating salinity-induced stress and enhancing the growth and physiological performance of Portulaca oleracea L. under NaCl concentrations of 0, 50, 70, and 100 mM for 50 days. A two-way ANOVA assessed the effects of NaCl concentration, ANE treatment, and their interaction. The results showed that ANE significantly increased plant height at 50 mM NaCl (p = 0.0011) but had no effect at higher salinity levels (p > 0.05). Shoot dry weight was… More >

YUFENG WANG¹, HUIFENG DANG¹, QIANQIAN WANG¹, SHUXIAO WU¹, LEI HAN¹, XU LUO¹, YINGXIA TIAN^1,*, HAILIN TANG^2,*

Oncology Research, DOI:10.32604/or.2025.063716

Abstract This review focuses on the metabolic issues related to mitochondrial pyruvate dehydrogenase phosphatase (PDP) in malignant tumors and its potential mechanisms. Recent research on tumor metabolic mechanisms has shown that PDP dysregulation is closely linked to metabolic reprogramming in tumor cells, and potentially promotes tumor. Research has comprehensively explored the structural-functional characteristics of PDP, its metabolic regulatory mechanisms, and its role in various types of malignant tumors. Nevertheless, several questions still exist regarding its potential mechanisms within acetylation, phosphorylation, hypoxia, immune infiltration, mitochondrial metabolism, drug resistance, oxidative phosphorylation, and tumor prognosis. This article intends to More >

YU ZHANG^1,2, QINGKUN WANG², YUE HAN², JUNJIE PIAO^2,*, XIUYING JIN^1,2,*

Oncology Research, DOI:10.32604/or.2025.063395

Abstract Background: Colorectal adenocarcinoma (COAD) is one of the most common gastrointestinal malignancies. There is a pressing need to recognize reliable biomarkers that can improve diagnostic accuracy, predict prognosis, and serve as effective molecular targets. Glutathione peroxidase 4 (GPX4) is an important antioxidant protein. Evidence demonstrates that abnormal expression of GPX4 is related to cancer initiation and progression. However, the role of GPX4 in COAD remains unclear. Methods: We employed bioinformatics analysis and conducted subsequent validation of biological processes, including cell counting kit-8 assay (CCK-8), colony formation assay, reverse transcription-quantitative polymerase chain reaction (RT-qPCR), 5-ethynyl-2′-deoxyuridine assay… More >

KHANH TOAN NGUYEN^*, THI HUONG PHAM, VAN LAM NGO, VAN TUAN BUI, VAN NHAT NGUYEN, THI PHUONG THAO NGUYEN, THI KHANH HA NGUYEN, THI THUY VAN NGUYEN

Oncology Research, DOI:10.32604/or.2025.061905

Abstract Aims: The study aimed to evaluate the effectiveness and adverse events of tyrosine kinase inhibitors (TKIs) in the first-line treatment of advanced non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations. Methods: A retrospective study on advanced NSCLC patients with EGFR mutations treated with TKIs as a first-line therapy at Nghe An Oncology Hospital, Vietnam between January 2017 and August 2023. The primary endpoints included objective response rate, progression-free survival, and tolerability. The secondary endpoint was overall survival. Results: A total of 211 patients received first-line treatment with Erlotinib (n = 74), Gefitinib (n… More >

CHENG CHENG^1,2,3, CHAO SHI^1,2, SHANG WU^1,2, WEIXING WU³, JINGPING LI^1,2, SINUO GAO^1,2, MENG HAN³, YIMIN WANG³, XIANGMEI ZHANG^2,4,*, YUNJIANG LIU^1,2,*

Oncology Research, DOI:10.32604/or.2025.061637

Abstract Objectives: While programmed cell death 1 (PD-1) inhibitors have improved cancer treatment, the function and mechanisms of programmed cell death ligand 1 (PD-L1), particularly when expressed by cancer cells, remain unclear. This study aims to explore the role of PD-L1 within breast cancer cells and identify key targets for future immunotherapy. Methods: RNA-seq was performed on breast cancer cells with silenced PD-L1 to screen for differentially expressed genes, followed by bioinformatics analysis. Clinical specimens from breast cancer patients undergoing primary surgery without preoperative treatment were collected, along with in vitro analysis to validate the potential mechanism. Results:… More >

Duc Hoa Pham, Bijender Kumar, Samia Adil, Jaehwan Kim^*

Journal of Renewable Materials, DOI:10.32604/jrm.2025.02025-0040

Abstract Increasing bio-based content in composites without compromising performance is an urgent duty toward sustainability and carbon neutralization. This paper reports high bio-content thermoset resin and cellulose long filament (CLF)-reinforced green composite by using a semi-bio imine-based hardener. The hardener (VDDM) is synthesized from DDM grafted with vanillin, and a bio-based vanillyl alcohol epoxy (VAE) monomer is used to prepare highly bio-based thermoset resin. The VAE-VDDM thermoset shows high tensile strength and Young’s modulus up to 94.8 MPa and 2.69 GPa, respectively. Further, a natural fiber-reinforced green composite is made with CLF and the prepared VAE-VDDM More >

Kun Li¹, Tianfu Li^2,*, Xiuwei Wang¹, Qingchun Meng¹, Zhenjie Wang¹, Jinyang Luo^1,2, Zhaohui Wang¹, Yuedong Yao²

Energy Engineering, DOI:10.32604/ee.2025.062876

Abstract CO₂ flooding for enhanced oil recovery (EOR) not only enables underground carbon storage but also plays a critical role in tertiary oil recovery. However, its displacement efficiency is constrained by whether CO₂ and crude oil achieve miscibility, necessitating precise prediction of the minimum miscibility pressure (MMP) for CO₂-oil systems. Traditional methods, such as experimental measurements and empirical correlations, face challenges including time-consuming procedures and limited applicability. In contrast, artificial intelligence (AI) algorithms have emerged as superior alternatives due to their efficiency, broad applicability, and high prediction accuracy. This study employs four AI algorithms—Random Forest Regression (RFR), Genetic… More >

Dongfeng Yang, Ruirui Zhang, Chuang Liu^*, Guoliang Bian

Energy Engineering, DOI:10.32604/ee.2025.062154

Abstract Under the current long-term electricity market mechanism, new energy and thermal power face issues such as deviation assessment and compression of generation space. The profitability of market players is limited. Simultaneously, the cooperation model among various energy sources will have a direct impact on the alliance’s revenue and the equity of income distribution within the alliance. Therefore, integrating new energy with thermal power units into an integrated multi-energy complementary system to participate in the long-term electricity market holds significant potential. To simulate and evaluate the benefits and internal distribution methods of a multi-energy complementary system… More >