QIUQIANG CHEN^1,*, XUEJUN GUO², WENXUE MA^3,*

Oncology Research, Vol., , DOI:10.32604/or.2023.042383

Abstract Cancer immunotherapy has emerged as a promising strategy for the treatment of cancer, with the tumor microenvironment (TME) playing a pivotal role in modulating the immune response. CD47, a cell surface protein, has been identified as a crucial regulator of the TME and a potential therapeutic target for cancer therapy. However, the precise functions and implications of CD47 in the TME during immunotherapy for cancer patients remain incompletely understood. This comprehensive review aims to provide an overview of CD47’s multifaced role in TME regulation and immune evasion, elucidating its impact on various types of immunotherapy outcomes, including checkpoint inhibitors and… More >

Guodong Zhang¹, Huifang Tao¹, Da Li¹, Kewei Chen², Guoxiang Li^1,*, Shuzhan Bai¹, Ke Sun^1,*

FDMP-Fluid Dynamics & Materials Processing, Vol., , DOI:10.32604/fdmp.2023.025566

Abstract A suitable channel structure can lead to efficient gas distribution and significantly improve the power density of fuel cells. In this study, the influence of two channel design parameters is investigated, namely, the ratio of the channel width to the bipolar plate ridge width (i.e., the channel ridge ratio) and the channel depth. The impact of these parameters is evaluated with respect to the flow pattern, the gas composition distribution, the temperature field and the fuel cell output capability. The results show that a decrease in the channel ridge ratio and an increase in the channel depth can effectively make… More >

POOJA BHADORIYA¹, RICHA SHARMA¹, REKHA MEHROTRA¹, SIMRAN KAUR¹, ISHA SRIVASTAVA¹, MUKUL JAIN², PRASHANT KAUSHIK^3,*

BIOCELL, Vol., , DOI:10.32604/biocell.2023.029564

Abstract In the present medicine world antibiotic resistance is one of the key threats to universal health coverage. Researchers continue to work hard to combat this global health concern. Phage therapy, an age-old practice during the early twentieth century, was outshined by the discovery of antibiotics. With the advent of widespread antibiotic resistance, phage therapy has again redeemed itself as a potential alternative owing to its adeptness to target bacteria precisely. Limited side effects, the ability to migrate to different body organs, a distinct mode of action, and proliferation at the infection site, make phages a profitable candidate to replace conventional… More >

Weigang Jin¹, Lei Chen^2,*, Yifei Li², Shencong Zheng², Yuqi Jiang², Hongkun Chen²

Energy Engineering, Vol., , DOI:10.32604/ee.2023.043021

Abstract Along with the increasing integration of renewable energy generation in AC-DC power networks, investigating the dynamic behaviors of this complex system with a proper equivalent model is significant. This paper presents an equivalent modeling method for the AC-DC power networks with doubly-fed induction generator (DFIG) based wind farms to decrease the simulation scale and computational burden. For the AC-DC power networks, the equivalent modeling strategy in accordance with the physical structure simplification is stated. Regarding the DFIG-based wind farms, the equivalent modeling based on the sequential identification of multi-machine parameters using the improved chaotic cuckoo search algorithm (ICCSA) is conducted.… More >

Yiwen Li^1,#, Hongyan Si^1,#, Peng Wang¹, Hai Luo¹, Minggui Shen², Xiaoping Rao³, Zhanqian Song², Shibin Shang², Zongde Wang^1,*, Shengliang Liao^1,*

Journal of Renewable Materials, Vol., , DOI:10.32604/jrm.2023.031089

Abstract Turpentine is a renewable and resourceful forest product. The deep processing and utilization of turpentine, particularly its primary component β-pinene, has garnered widespread attention. This study aimed to synthesize 40 derivatives of β-pinene, including nopinone, 3-cyanopyridines of nopinone, myrtanyl acid, myrtanyl acylthioureas, and myrtanyl amides. We assessed the antiviral activities of these β-pinene derivatives against influenza virus A/Puerto Rico/8/34 (H1N1) using the 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method. The β-pinene derivatives were used before and after cellular infection with the influenza virus to evaluate their preventive and therapeutic effects against the H1N1 virus. The results showed that only compound 10o exhibited a preventive… More >

Hyangjin Park¹, Haeryun Cho², So Yeon Yoo^3,*

International Journal of Mental Health Promotion, Vol., , DOI:10.32604/ijmhp.2023.041490

Abstract This study examined factors related to the psychological well-being of older adults and built and verified a model for predicting psychological well-being. The participants were 350 older adults aged over 60 years who lived in South Korea and were active in the local community. The model proposed in this study was found to be suitable. Depression, self-efficacy, and social support had a direct effect on the psychological well-being of older adults, while depression, activities of daily living (ADLs), and self-efficacy had an indirect effect. Self-efficacy and social support mediated the relationship between depression and psychological well-being, and self-efficacy mediated the… More >

Guangyan Fan, Fuyong Su^*, Cunwang Li, Bin Li

Frontiers in Heat and Mass Transfer, Vol., , DOI:10.32604/fhmt.2023.043221

Abstract To investigate the flow and heat transfer process of blast furnace slag through the slag trench after the slag is discharged, a three-dimensional physical model is established and simulated according to the actual size of the slag trench and the physical properties of the high-temperature slag. The temperature fied and flow field distribution of the high-temperature slag liquid inside the slag trench is obtained by numerical simulation under different working conditions, and the effects of operating conditions such as slag trench inclination, high-temperature slag inlet flow rate, and inlet temperature are investigated. The results show that the flow rate of… More >

Jennifer Marini^1,*, Audrey Vanhaudenhuyse^2,3, Marie Lacasse¹, Maud Jaspard¹, Marie-Elisabeth Faymonville⁴, Hadrien Tasset³, Christophe F. Chantrain^1,#, Charlotte Grégoire^2,#

Psycho-Oncologie, Vol., , DOI:10.32604/po.2023.043341

Abstract Hypnosis is a modified state of consciousness which showed its benefits to decrease different symptoms, mainly pain. During the last decade, this technique has also been proposed to adults with cancer to improve other symptoms, such as emotional distress, fatigue, or sleep difficulties. In pediatric oncology, hypnosis is also used to decrease disease-, treatment-, and procedure-related pain and anxiety. The learning of self-hypnosis and self-care techniques also improves the well-being of adults or children with cancer, their parents, and their siblings. Through several clinical cases, we will illustrate how hypnosis and self-care techniques have been implemented in the pediatric haemato-oncology… More >

Quan Zhou^1,*, Yulong Zheng¹, Minhui Chen², Kaijun Wei²

Computer Systems Science and Engineering, Vol., , DOI:10.32604/csse.2023.039908

Abstract In recent years, the issue of preserving the privacy of parties involved in blockchain transactions has garnered significant attention. To ensure privacy protection for both sides of the transaction, many researchers are using ring signature technology instead of the original signature technology. However, in practice, identifying the signer of an illegal blockchain transaction once it has been placed on the chain necessitates a signature technique that offers conditional anonymity. Some illegals can conduct illegal transactions and evade the law using ring signatures, which offer perfect anonymity. This paper firstly constructs a conditionally anonymous linkable ring signature using the Diffie-Hellman key… More >

Awny Sayed¹, Sohair Kinlany², Alaa Zaki², Ahmed Mahfouz^2,3,*

CMC-Computers, Materials & Continua, Vol., , DOI:10.32604/cmc.2023.040256

Abstract Face verification systems are critical in a wide range of applications, such as security systems and biometric authentication. However, these systems are vulnerable to adversarial attacks, which can significantly compromise their accuracy and reliability. Adversarial attacks are designed to deceive the face verification system by adding subtle perturbations to the input images. These perturbations can be imperceptible to the human eye but can cause the system to misclassify or fail to recognize the person in the image. To address this issue, we propose a novel system called VeriFace that comprises two defense mechanisms, adversarial detection, and adversarial removal. The first… More >