Dan Zhao¹, Yang You², Chuanwen Luo^3,*, Ting Chen^4,*, Yang Liu⁵

CMES-Computer Modeling in Engineering & Sciences, Vol., , DOI:10.32604/cmes.2023.045400

Abstract In recent years, the research field of data collection under local differential privacy (LDP) has expanded its focus from elementary data types to include more complex structural data, such as set-value and graph data. However, our comprehensive review of existing literature reveals that there needs to be more studies that engage with key-value data collection. Such studies would simultaneously collect the frequencies of keys and the mean of values associated with each key. Additionally, the allocation of the privacy budget between the frequencies of keys and the means of values for each key does not yield an optimal utility tradeoff.… More >

Peng Liao¹, Chaoge Liu², Jie Yin^1,3,*, Zhi Wang², Xiang Cui²

CMES-Computer Modeling in Engineering & Sciences, Vol., , DOI:10.32604/cmes.2024.043855

Abstract Digital assets have boomed over the past few years with the emergence of Non-fungible Tokens (NFTs). To be specific, the total trading volume of digital assets reached an astounding $55.5 billion in 2022. Nevertheless, numerous security concerns have been raised by the rapid expansion of the NFT ecosystem. NFT holders are exposed to a plethora of scams and traps, putting their digital assets at risk of being lost. However, academic research on NFT security is scarce, and the security issues have aroused rare attention. In this study, the NFT ecological process is comprehensively explored. This process falls into five different… More >

Yuming Tang^1,#, Yitian Zhang^2,#, Tao Niu¹, Zhen Li^2,3,*, Zijian Zhang^1,3, Huaping Chen⁴, Long Zhang⁴

CMES-Computer Modeling in Engineering & Sciences, Vol., , DOI:10.32604/cmes.2024.030084

Abstract Federated Learning (FL), as an emergent paradigm in privacy-preserving machine learning, has garnered significant interest from scholars and engineers across both academic and industrial spheres. Despite its innovative approach to model training across distributed networks, FL has its vulnerabilities; the centralized server-client architecture introduces risks of single-point failures. Moreover, the integrity of the global model—a cornerstone of FL—is susceptible to compromise through poisoning attacks by malicious actors. Such attacks and the potential for privacy leakage via inference starkly undermine FL’s foundational privacy and security goals. For these reasons, some participants unwilling use their private data to train a model, which… More >

ANGUO WU^1,#, JIAO YAN^2,3,#, TING SU^2,4, CHI FENG¹, XIN LONG^5,6, YIRU PAN¹, RUPEI YE², TIAN XIA², HANAN LONG², JIANMING WU^1,*, XIULI XIAO^2,*

Oncology Research, Vol., , DOI:10.32604/or.2024.046139

Abstract Breast cancer, a predominant global health issue, requires ongoing exploration of new therapeutic strategies. Palbociclib (PAL), a well-known cyclin-dependent kinase (CDK) inhibitor, plays a critical role in breast cancer treatment. While its efficacy is recognized, the interplay between PAL and cellular autophagy, particularly in the context of the RAF/MEK/ERK signaling pathway, remains insufficiently explored. This study investigates PAL’s inhibitory effects on breast cancer using both in vitro (MCF7 and MDA-MB-468 cells) and in vivo (tumor-bearing nude mice) models. Aimed at elucidating the impact of PAL on autophagic processes and exploring the potential of combining it with trametinib (TRA), an MEK… More > Graphic Abstract

ANDI ZHAO^1,2,#, YUE WANG^3,#, ZIJIN WANG^1,2, QING SHAO^1,2, QI GONG^1,2, HUI ZHU^1,2, SHIYA SHEN^1,2, HU LIU^1,2,*, XUEJUAN CHEN^1,2,*

Oncology Research, Vol., , DOI:10.32604/or.2024.045972

Abstract Numerous studies have characterized the critical role of circular RNAs (circRNAs) as regulatory factors in the progression of multiple cancers. However, the biological functions of circRNAs and their underlying molecular mechanisms in the progression of uveal melanoma (UM) remain enigmatic. In this study, we identified a novel circRNA, circ_0053943, through re-analysis of UM microarray data and quantitative RT-PCR. Circ_0053943 was found to be upregulated in UM and to promote the proliferation and metastatic ability of UM cells in both in vitro and in vivo settings. Mechanistically, circ_0053943 was observed to bind to the KH1 and KH2 domains of insulin-like growth… More > Graphic Abstract

Anas Bilal¹, Azhar Imran², Talha Imtiaz Baig^3,4, Xiaowen Liu^1,*, Haixia Long¹, Abdulkareem Alzahrani⁵, Muhammad Shafiq⁶

Computer Systems Science and Engineering, Vol., , DOI:10.32604/csse.2023.039672

Abstract Artificial Intelligence (AI) is being increasingly used for diagnosing Vision-Threatening Diabetic Retinopathy (VTDR), which is a leading cause of visual impairment and blindness worldwide. However, previous automated VTDR detection methods have mainly relied on manual feature extraction and classification, leading to errors. This paper proposes a novel VTDR detection and classification model that combines different models through majority voting. Our proposed methodology involves preprocessing, data augmentation, feature extraction, and classification stages. We use a hybrid convolutional neural network-singular value decomposition (CNN-SVD) model for feature extraction and selection and an improved SVM-RBF with a Decision Tree (DT) and K-Nearest Neighbor (KNN)… More >

Awais Ahmad¹, Sohail Jabbar^1,*, Sheeraz Akram¹, Anand Paul², Umar Raza³, Nuha Mohammed Alshuqayran¹

CMC-Computers, Materials & Continua, Vol., , DOI:10.32604/cmc.2024.045385

Abstract This paper presents an innovative approach to enhance the querying capability of ChatGPT, a conversational artificial intelligence model, by incorporating voice-based interaction and a convolutional neural network (CNN)-based impaired vision detection model. The proposed system aims to improve user experience and accessibility by allowing users to interact with ChatGPT using voice commands. Additionally, a CNN-based model is employed to detect impairments in user vision, enabling the system to adapt its responses and provide appropriate assistance. This research tackles head-on the challenges of user experience and inclusivity in artificial intelligence (AI). It underscores our commitment to overcoming these obstacles, making ChatGPT… More >

Yunhong Zhang^1,2,*, Yonghui Yang^1,2, Jiawei Mao^1,2

Phyton-International Journal of Experimental Botany, Vol., , DOI:10.32604/phyton.2023.046811

Abstract Alginate oligosaccharides (AOS) enhance drought resistance in wheat (Triticum aestivum L.), but the definite mechanisms remain largely unknown. The physiological and transcriptome responses of wheat seedlings treated with AOS were analyzed under drought stress simulated with polyethylene glycol-6000. The results showed that AOS promoted the growth of wheat seedlings and reduced oxidative damage by improving peroxidase and superoxide dismutase activities under drought stress. A total of 10,064 and 15,208 differentially expressed unigenes (DEGs) obtained from the AOS treatment and control samples at 24 and 72 h after dehydration, respectively, were mainly enriched in the biosynthesis of secondary metabolites (phenylpropanoid biosynthesis,… More >

XINFENG ZHANG^1,2,#, SHUANG LI^2,#, MEIRU SONG^1,2, YUE CHEN³, LIANGZHENG CHANG³, ZHERUI LIU⁴, HONGYUAN DAI³, YUTAO WANG⁴, GANGQI YANG³, YUN JIANG^5,6,*, YINYING LU^1,2,*

Oncology Research, Vol., , DOI:10.32604/or.2024.046231

Abstract Liver cancer is a prevalent malignant cancer, ranking third in terms of mortality rate. Metastasis and recurrence primarily contribute to the high mortality rate of liver cancer. Hepatocellular carcinoma (HCC) has low expression of focal adhesion kinase (FAK), which increases the risk of metastasis and recurrence. Nevertheless, the efficacy of FAK phosphorylation inhibitors is currently limited. Thus, investigating the mechanisms by which FAK affects HCC metastasis to develop targeted therapies for FAK may present a novel strategy to inhibit HCC metastasis. This study examined the correlation between FAK expression and the prognosis of HCC. Additionally, we explored the impact of… More >

Isabelle Cuchet^1,*, Michael Dambrun², Axelle Van Lander³

Psycho-Oncologie, Vol., , DOI:10.32604/po.2024.047213

Abstract The need for home palliative care is increasing in all Western countries. Community pharmacists are local professionals whose role in end-of-life care at home remains poorly understood. The aim of this study is to understand how community pharmacists see their role in end-of-life home care in France, and to analyze their experiences of this care. An online questionnaire was distributed to community pharmacists working in France between December 2022 and March 2023. Of the 136 respondents to the questionnaire, 87% had accompanied at least one patient at the end of life in the 3 months preceding the survey. Therapeutic education… More >