BEHROOZ JOHARI1,2,#,*, MILAD PARVINZAD LEILAN1,#, MAHMOUD GHARBAVI3, YOUSEF MORTAZAVI1, ALI SHARAFI2, HAMED REZAEEJAM4
Oncology Research, Vol., , DOI:10.32604/or.2023.043576
Abstract The Myc gene is the essential oncogene in triple-negative breast cancer (TNBC). This study investigates the
synergistic effects of combining Myc decoy oligodeoxynucleotides-encapsulated niosomes-selenium hybrid
nanocarriers with X-irradiation exposure on the MDA-MB-468 cell line. Decoy and scramble ODNs for Myc
transcription factor were designed and synthesized based on promoter sequences of the Bcl2 gene. The nanocarriers
were synthesized by loading Myc ODNs and selenium into chitosan (Chi-Se-DEC), which was then encapsulated in
niosome-nanocarriers (NISM@Chi-Se-DEC). FT-IR, DLS, FESEM, and hemolysis tests were applied to confirm its
characterization and physicochemical properties. Moreover, cellular uptake, cellular toxicity, apoptosis, cell cycle, and
scratch repair… More >
Graphic Abstract