Karunanithi Praveen kumar, Perumal Sivanesan^*

Computer Systems Science and Engineering, Vol.41, No.1, pp. 67-82, 2022, DOI:10.32604/csse.2022.018867

Abstract In this work, we propose a context-aware switching of routing protocol scheme for specific application requirements of IoT in real-time using a software-defined networking controller in wireless sensor networks. The work planned has two stages i) Selection of suitable routing protocol (RP) for given IoT applications using higher cognitive process and ii) Deployment of the corresponding routing protocol. We use the supervised learning-regression method for classification of the routing protocol while considering the network parameters like stability, path delay, energy utilization, and throughput. The chosen routing protocol will be set in the sensor network using a software-defined networking controller in… More >

Baiqing Zhou¹, Na Li^1,*, Duan Lu¹, Jinyue Xia²

Computer Systems Science and Engineering, Vol.41, No.1, pp. 127-140, 2022, DOI:10.32604/csse.2022.017750

Abstract With the rapid development of the economy, China’s environment has been damaged severely, which has attracted much attention from scholars and the local government. The concept of green development has been an underlying trend since 2012, and it is of great significance to explore the relationship between economic growth and environmental quality. Huzhou is a prefecture-level city under the jurisdiction of Zhejiang Province, and it is one of the 27 cities in the central area of the Yangtze River Delta. In recent years, this city develops well not only in economic development but also in maintaining a green environment. In… More >

Hongfei Wei^1,*, Hui Zhao², Xinlong Shi¹, Shuang Liang³

Computer Systems Science and Engineering, Vol.41, No.1, pp. 51-65, 2022, DOI:10.32604/csse.2022.017739

Abstract A laser beam is a heat source with a high energy density; this technology has been rapidly developed and applied in the field of welding owing to its potential advantages, and supplements traditional welding techniques. An in-depth analysis of its operating process could establish a good foundation for its application in China. It is widely understood that the welding process is a highly nonlinear and multi-variable coupling process; it comprises a significant number of complex processes with random uncertain factors. Because of their nonlinear mapping and self-learning characteristics, artificial neural networks (ANNs) have certain advantages in comparison to traditional methods… More >

MENGQIU CHENG^1,2, WEI CAO², GUODONG CAO¹, XIN XU^1,2,*, BO CHEN^1,*

BIOCELL, Vol.46, No.1, pp. 97-109, 2022, DOI:10.32604/biocell.2021.015608

Abstract Gastric cancer (GC) is one of the most common cancer worldwide. Although emerging evidence indicates that autophagy-related long non-coding RNA (lncRNA) plays an important role in the progression of GC, the prognosis of GC based on autophagy is still deficient. The Cancer Genome of Atlas stomach adenocarcinoma (TCGA-STAD) dataset was downloaded and separated into a training set and a testing set randomly. Then, 24 autophagy-related lncRNAs were found strongly associated with the survival of the TCGA-STAD dataset. 11 lncRNAs were selected to build the risk score model through the least absolute shrinkage and selection operator (LASSO) regression. Every patient got… More >

JIANFEI GAO¹, KANGNING XIONG^2,*, WEIJIE LI¹, WEI ZHOU³

BIOCELL, Vol.46, No.1, pp. 285-296, 2022, DOI:10.32604/biocell.2021.016253

Abstract Kadsura coccinea (Lem.) is a woody wine plant with a peculiar fruit enriched in important health-promoting compounds. The non-editable part of the fruit, i.e., the seed and peel, represents more than 60% of the fruit and is considered a biowaste. This significantly restricts the development of the K. coccinea fruit industry. Clarifying the metabolic components of the different fruit parts can help to improve the utilization rate and valorization of K. coccinea. Herein, we evaluated K. coccinea fruit peel, pulp, and seed using widely-targeted metabolomics and quantified a set of 736 bioactive compounds from 11 major metabolite classes. The most… More >

PENG YANG^1,*, ZHIYING ZOU¹, XULING GAO²

BIOCELL, Vol.46, No.1, pp. 207-218, 2022, DOI:10.32604/biocell.2021.014728

Abstract Recent studies have shown that the microtubule disrupting protein Stathmin 1 (STMN1) is differentially expressed in AML patients and healthy control. The aim of this study was to explore the effects and molecular mechanism of STMN1 in AML. Here, the expression of STMN1 in peripheral blood cells (PBMCs) and bone marrow of AML patients and healthy volunteers was detected by RT-PCR and Western blot. STMN1 expression was regulated by transfected with STMN1 overexpressed plasmid or shRNA in two human leukemia cell lines K562 and HL60. Cell proliferation was examined by CCK8 and Edu staining. Annexin V and TUNEL assays were… More >

JIANBO LU^1,2,#,*, XIAOHAN SUN^3,#, XU MA^1,2,*

BIOCELL, Vol.46, No.1, pp. 185-193, 2022, DOI:10.32604/biocell.2021.015301

Abstract The concentration of cell-free fetal DNA fragments should be detected before noninvasive prenatal testing (NIPT). The fetal DNA molecules have significant clinical potential in determining the overall performance of NIPT and clinical interpretation. It is important to measure fetal DNA fraction before NIPT. However, there is still little research on how to calculate the concentration of female fetuses. Two estimation approaches were proposed to calculate fetal DNA fraction, including the fragments size-based approach, aneuploid-based approach, which are all approaches based on chromosome segments. Based on high-throughput sequencing data, two approaches to calculate the DNA fraction of male fetuses were tested… More >

QIANSHAN TAO^#, QING ZHANG^#, HUIPING WANG, HAO XIAO, MEI ZHOU, LINLIN LIU, HUI QIN, JIYU WANG, FURUN AN, ZHIMIN ZHAI^*, YI DONG^*

BIOCELL, Vol.46, No.1, pp. 159-169, 2022, DOI:10.32604/biocell.2021.014139

Abstract Acute myeloid leukemia (AML) is regarded as a stem cell disease. However, no one unique marker is expressed on leukemia stem cells (LSC) but not on leukemic blasts nor normal hematopoietic stem cells (HSC). CD34⁺ CD38- with or without CD123 or CD44 subpopulations are immunophenotypically defined as putative LSC fractions in AML. Nevertheless, markers that can be effectively and simply held responsible for the intrinsical heterogeneity of LSC is still unclear. In the present study, we examined the frequency of three different LSC subtypes (CD34⁺ CD38^-, CD34⁺ CD38^- CD123⁺ , CD34⁺ CD38^- CD44⁺ ) in AML at diagnosis. We then… More >

SICONG WANG¹, RUIJIN LIU², QIUYUAN HAN², KAIJIANG YU^3,*

BIOCELL, Vol.46, No.1, pp. 149-158, 2022, DOI:10.32604/biocell.2021.013027

Abstract Acute kidney injury (AKI), commonly occurring as complications of sepsis, cardiac surgery, and liver or kidney transplantation, is a critical care syndrome. It is well known that lipopolysaccharide (LPS) shock is a common triggering factor for AKI. This study is aimed to examine the effect of flavonoid compound hispidulin on LPS-induced AKI. For this, renal tubular epithelial cell HK-2 was treated with LPS to establish an in vitro model of AKI. The effect of hispidulin on HK-2 cell viability was examined using CCK-8 assay. Cell apoptosis was determined by TUNEL and flow cytometry. Apoptosis marker proteins were determined by using… More >

AASTHA MITTAL¹, NEELAM MAHALA¹, KOWTHAVARAPU VENKATA KRISHNA², UMA S. DUBEY^1,*, SUNIL KUMAR DUBEY^2,3,*

BIOCELL, Vol.46, No.1, pp. 127-136, 2022, DOI:10.32604/biocell.2021.015932

Abstract Sorafenib, a multikinase inhibitor used for the treatment of hepatocellular carcinoma, is limited by its low oral bioavailability. To overcome this drawback, we have developed novel camel milk casein-derived nanoparticles as a drug delivery system. Camel milk casein is not only biocompatible on oral administration but is actually a dietary protein of pharmaceutical relevance. Casein is used because of its amphiphilic nature, self-assembling property, ability to show sustained release, and capability of encapsulating both hydrophilic and hydrophobic drugs. In this study, camel milk casein nanoparticles loaded with sorafenib were developed and characterized. Characterization of casein nanoparticles was done by dynamic… More >