Ran Ma^1,#, Chunyang Zhang^2,#, Wei Xu^1,*

International Journal of Mental Health Promotion, DOI:10.32604/ijmhp.2025.060351

Abstract Maintaining optimal quality of life (QoL) is a pivotal for “successful aging”. Understanding how the QoL of the elderly develops and what role psychological factors play in its development will help improve QoL from a psychological perspective. Embedded within the lifespan theory of control, this longitudinal study aimed to (1) map the temporal trajectory of QoL among Chinese older adults, (2) examine differential effects of tripartite negative emotions (stress, anxiety, depression), and (3) test the moderating role of control strategies (goal engagement, goal disengagement, self-protection) in emotion-QoL dynamics. A prospective cohort of 345 community-dwelling older… More >

Zhen-Yu Chen¹, Yue-RU Wang¹, De-Yi Teng¹, Yan-Fang Xue¹, Gui-Chang Jiang^1,2,*

Journal of Polymer Materials, DOI:10.32604/jpm.2025.063342

Abstract PU, or polyurethane, features a repeating urethane group (-NH-COO-) in its molecular structure. Traditionally, PUs are synthesized from isocyanate and polyol compounds derived from fossil resources through polymerization reactions. The depletion of fossil fuels and the increasing climate problems call for the expansion of more renewable sources of chemicals, such as modern biomass. However, the conversion of biomass into chemicals is challenging due to the inherent molecular complexity of its composition. In recent years, advances in green chemistry have led researchers to focus on developing bio-based polyurethanes by sourcing polyols, isocyanates, and chain extender precursors More >

JINGDAN QUAN¹, ZIXIN WAN¹, WEI WU², XINYUAN CAO², JIAYUAN QIU², XIAOYE LIU², ZHIWEI ZHANG^1,*

Oncology Research, DOI:10.32604/or.2025.063005

Abstract One of the most prevalent malignant tumors worldwide, stomach cancer still has a high incidence and fatality rate in China, and the number of young people developing early-onset gastric cancer is steadily increasing. The 5-year survival rate of stomach cancer is typically 30%–35%, the prognosis is bad, the patients’ quality of life is low, and the progression of advanced gastric cancer cannot be effectively managed despite the use of surgical surgery, chemotherapy, and other medicines. We urgently need molecular biomarkers with high specificity and sensitivity to increase the early gastric cancer detection rate, extend patient… More >

WENYING ZHENG^1,#, YANYAN SHANG^1,#, KAI DU¹, AILING LUO¹, LIJUN PEI¹, MEIQI LI¹, GUOPING ZHANG^2,*, MIN DENG^1,*

Oncology Research, DOI:10.32604/or.2025.060958

Abstract Background: Alterations in splicing factors contribute to aberrant alternative splicing (AS), which subsequently promotes tumor progression. The splicing factor polypyrimidine tract binding protein 1 (PTBP1) has been shown to facilitate cancer progression by modulating oncogenic variants. However, its specific role and underlying mechanisms in hepatocellular carcinoma (HCC) remain to be elucidated. Methods: PTBP1 expression was evaluated in HCC tissues and cell lines. Subsequently, cells were transfected with vectors designed for PTBP1 overexpression or downregulation. The biological function of PTBP1 was assessed in vitro and in vivo using MTS assays, colony formation assays, transwell assays, xenograft formation, tail… More > Graphic Abstract

YOUYANG HU^1,#, YISHU LUO^1,#, TIANYUE XIE¹, YUEHUA CHEN^1,2, JUN ZHAO¹, WEICHAO JI³, ZHIWEI YAN³, SITONG QIU³, KEXIN GAO³, HAIXIA ZHU⁴, LIMIN MA^1,*, QIYOU YIN^1,*

Oncology Research, DOI:10.32604/or.2025.060021

Abstract Objective: Neuroblastoma (NB) is frequently associated with high-risk pediatric cases that demonstrate limited response to cisplatin, contributing to a poor prognosis. Recent studies have explored the role of tumor cell senescence in increasing sensitivity to this chemotherapy agent. This study aims to identify genes related to cell senescence in children diagnosed with NB, evaluate their influence on cisplatin sensitivity, and investigate potential strategies to enhance the efficacy of chemotherapy. Methods: Gene expression profiles and clinical data were obtained for 498 NB patients from the GEO database (GSE49710). The study focused on identifying genes that were… More >

THAINá RODRIGUES^1,2, PATRíCIA CANDIDO^1,3, FERES CAMARGO MALUF¹, POLIANA ROMãO¹, CAROLINA MIE MIOSHI¹, VANESSA RIBEIRO GUIMARãES¹, JULIANA ALVES DE CAMARGO¹, KARINA SERAFIM DA SILVA^1,4, GABRIEL ARANTES DOS SANTOS¹, IRAN AMORIM SILVA¹, KATIA RAMOS MOREIRA LEITE¹, WILLIAM C. NAHAS⁵, SABRINA T. REIS^1,3, RUAN PIMENTA^1,6, NAYARA IZABEL VIANA^1,7,*

Oncology Research, DOI:10.32604/or.2025.055306

Abstract Objectives: Bladder Cancer (BC) is one of the most commonly diagnosed malignancies worldwide, with high rates of mortality and morbidity. It can be classified as non-muscle invasive bladder cancer (NMIBC) or muscle-invasive bladder cancer (MIBC), with radical cystectomy being the treatment for MIBC, which significantly reduces quality of life. MicroRNAs (miRs) act as critical genetic regulators, with both oncogenic and tumor-suppressive roles. MiR-10a is described as a tumor suppressor in various neoplasms, but its role in BC is controversial. This study aims to assess the activity of miR-10a in cellular invasion and proliferation in two… More >

Tatyana Lyubimova^1,*, Anatoly Lepikhin², Yanina Parshakova¹, Andrey Bogomolov², Alibek Issakhov³

FDMP-Fluid Dynamics & Materials Processing, DOI:10.32604/fdmp.2025.061649

Abstract The article presents the results of in-kind measurements and numerical modeling of the formation of water characteristics in the Kama River, which is used for technical water supply in the production of potash fertilizers. In the warm season, risks arise that threaten the sustainability of the water supply. It was found that in the summer, when the studied section of the Kama River is backed up by the Kama Hydroelectric Power Station, there is a significant decrease in flow rates, which leads to vertical stratification of water properties. This, in turn, significantly limits the possibilities… More >

Yining Zhou¹, Yufeng Li², Chen Zhang², Tao Wu¹, Jingru Zhang², Bowen Yun², Rui Tan², Wei Yan^2,*

Energy Engineering, DOI:10.32604/ee.2025.062199

Abstract This study investigated the micro-sliding frictional behavior of shale in fracturing fluids under varying operational conditions using Chang 7 shale oil reservoir core samples. Through systematic micro-sliding friction experiments, the characteristics and governing mechanisms of shale friction were elucidated. Complementary analyses were conducted to characterize the mineral composition, petrophysical properties, and micromorphology of the shale samples, providing insights into the relationship between microscopic structure and frictional response. In this paper, the characteristics and variation law of shale micro-sliding friction under different types of graphite materials as additives in LGF-80 (Low-damage Guar Fluid) oil flooding recoverable… More >

Sagvan Y. Musa^1,2, Baravan A. Asaad^3,4,*, Hanan Alohali⁵, Zanyar A. Ameen⁶, Mesfer H. Alqahtani⁷

CMES-Computer Modeling in Engineering & Sciences, DOI:10.32604/cmes.2025.062524

Abstract This paper introduces fuzzy N-bipolar soft (FN-BS) sets, a novel mathematical framework designed to enhance multi-criteria decision-making (MCDM) processes under uncertainty. The study addresses a significant limitation in existing models by unifying fuzzy logic, the consideration of bipolarity, and the ability to evaluate attributes on a multinary scale. The specific contributions of the FN-BS framework include: (1) a formal definition and set-theoretic foundation, (2) the development of two innovative algorithms for solving decision-making (DM) problems, and (3) a comparative analysis demonstrating its superiority over established models. The proposed framework is applied to a real-world case More >

Magdy Nagy^*

CMES-Computer Modeling in Engineering & Sciences, DOI:10.32604/cmes.2025.061865

Abstract In this present work, we propose the expected Bayesian and hierarchical Bayesian approaches to estimate the shape parameter and hazard rate under a generalized progressive hybrid censoring scheme for the Kumaraswamy distribution. These estimates have been obtained using gamma priors based on various loss functions such as squared error, entropy, weighted balance, and minimum expected loss functions. An investigation is carried out using Monte Carlo simulation to evaluate the effectiveness of the suggested estimators. The simulation provides a quantitative assessment of the estimates accuracy and efficiency under various conditions by comparing them in terms of More >