Cai Ming Liu^1,2,3, Yan Zhang^1,2,*, Zhihui Hu^1,2, Chunming Xie¹

CMC-Computers, Materials & Continua, Vol., , DOI:10.32604/cmc.2023.045282

Abstract Artificial immune detection can be used to detect network intrusions in an adaptive approach and proper matching methods can improve the accuracy of immune detection methods. This paper proposes an artificial immune detection model for network intrusion data based on a quantitative matching method. The proposed model defines the detection process by using network data and decimal values to express features and artificial immune mechanisms are simulated to define immune elements. Then, to improve the accuracy of similarity calculation, a quantitative matching method is proposed. The model uses mathematical methods to train and evolve immune elements, increasing the diversity of… More >

Ruchun Jia, Jianwei Zhang^*, Yi Lin

CMC-Computers, Materials & Continua, Vol., , DOI:10.32604/cmc.2024.044149

Abstract With the popularization of the Internet and the development of technology, cyber threats are increasing day by day. Threats such as malware, hacking, and data breaches have had a serious impact on cybersecurity. The network security environment in the era of big data presents the characteristics of large amounts of data, high diversity, and high real-time requirements. Traditional security defense methods and tools have been unable to cope with the complex and changing network security threats. This paper proposes a machine-learning security defense algorithm based on metadata association features. Emphasize control over unauthorized users through privacy, integrity, and availability. The… More >

MIN SHEN^1,2, XIAOMAN XU^1,2, GUANGLING SUN¹, LIANGZHU WANG¹, TAO YING¹, HANG SU¹, WEI WANG¹, QINGHUA CAO^1,*, ZHEZHE SUN^1,*

BIOCELL, Vol., , DOI:10.32604/biocell.2023.047640

Abstract Objective: Circular RNAs (circRNAs) have been shown to involve in pathological processes of ischemic stroke (IS), including autophagy. This study was designed to explore the effect of circR-ZC3HC1 on neuronal autophagy in IS and the related mechanisms. Methods: Expression of circR-ZC3HC1 in blood samples of IS patients and healthy controls was detected. Hippocampal neurons were treated with oxygen and glucose deprivation (OGD) to establish IS in vitro model. The expression of LC3 and p62 and the number of autophagosomes were examined to evaluate the autophagy level of OGD induced neurons using western blotting and transmission electron microscope. Cell apoptosis rate… More >

YANG XU^1,#, HONGYUN LI^1,#, GE YOU^2,*

BIOCELL, Vol., , DOI:10.32604/biocell.2023.045030

Abstract Background: Colorectal cancer (CRC) constitutes the leading cause of death worldwide. Chemoresistance and tumor immune evasion are critical contributors to therapeutic failure in cancer patients. CKLF-like MARVEL transmembrane domain-containing 6 (CMTM6) is aberrantly expressed in various cancers and can regulate tumor immunity. However, its role in chemoresistance and tumor immunity of CRC is not well understood. Methods: Online bioinformatics tools were used to analyze expression and prognosis of CMTM6 in CRC patients. CRC cells were transfected with si-CMTM6. Subsequently, the effects on CRC cell viability and chemoresistance were investigated by CCK-8 assay and flow cytometer. Furthermore, CRC cell-induced macrophage recruitments… More > Graphic Abstract

WEI ZHENG¹, CHENG LIU^2,*

BIOCELL, Vol., , DOI:10.32604/biocell.2023.044211

Abstract Objective: Intracranial aneurysm (IA) represents a devastating disease with high rates of disability and mortality, which is initiated by dysfunction of endothelial cells (ECs). Evidence suggests the dysregulation of the E3 ubiquitin ligase family during EC injury. In this work, the role of an E3 ubiquitin ligase, casitas B lymphoma-B (CBL-B), was explored in human brain microvascular EC (HBMEC) function through the NLRP3 pathway. Methods: In vitro IA model was induced by treating HBMECs with oxidized low-density lipoprotein (ox-LDL). The levels of CBL-B and pyroptosis-related proteins NLRP3, ASC, cleaved caspase-1, and GSDME-N were determined by real-time-quantitative polymerase chain reaction and… More >

XIAOFENG GAO^1,2,3,4, JUANJUAN GE³, XUZHENG GAO^1,3, NA MEI^1,3, YANTING SU³, SHIGANG SHAN³, WENBIN QIAN³, JIANGHENG GUAN⁵, ZHENWANG ZHANG^1,3,*, LONG WANG^2,3,4,*

Oncology Research, Vol., , DOI:10.32604/or.2023.046712

Abstract Background: IQGAP3 plays a crucial role in regulating cell proliferation, division, and cytoskeletal organization. Abnormal expression of IQGAP3 has been linked to various tumors, but its function in glioma is not well understood. Methods: Various methods, including genetic differential analysis, single-cell analysis, ROC curve analysis, Cox regression, Kaplan-Meier analysis, and enrichment analysis, were employed to analyze the expression patterns, diagnostic potential, prognostic implications, and biological processes involving IQGAP3 in normal and tumor tissues. The impact of IQGAP3 on immune infiltration and the immune microenvironment in gliomas was evaluated using immunofluorescence. Additionally, the cBioPortal database was used to analyze copy number… More > Graphic Abstract

ZHEN LIU^1,#, LIANGWANG YANG^2,#, ZHENGXING XIE¹, HUI YU³, TIANYI GU³, DAOMING SHI⁴, NING CAI^1,*, SHENGHUA ZHUO^2,*

Oncology Research, Vol., , DOI:10.32604/or.2024.045769

Abstract Clinical data indicates that glioma patients have poor treatment outcomes and clinical prognosis. The role of olfactory signaling pathway-related genes (OSPRGs) in glioma has not been fully elucidated. In this study, we aimed to investigate the role and relationship between OSPRGs and glioma. Univariate and multivariate Cox regression analyses were performed to assess the relationship between OSPRGs and the overall survival of glioma based on public cohorts, and the target gene (G Protein Subunit Alpha L, GNAL) was screened. The association of GNAL expression with clinicopathological characteristics, gene mutation landscape, tumor immune microenvironment (TIME), deoxyribonucleic acid (DNA) methylation, and naris-occlusion… More >

Yaping Zhou^1,2,5,#, He Zhong^3,#, Xiaojun Li^4,*, Yanhui Xiang^1,2,5,*

International Journal of Mental Health Promotion, Vol., , DOI:10.32604/ijmhp.2023.046598

Abstract Fathers play an important role in adolescents’ development, which is significant for their development and influences their mental health, including feeling of loneliness. However, the effects and mechanisms of father-love absence on individual loneliness are not clear. Based on the social functionalist theory and the social needs theory, this study examines the influence of individual father-love absence on loneliness and its underlying mechanisms. A questionnaire survey was administered to 319 junior high school students and 1,476 high school students. The results showed that adolescents with father-love absence had higher levels of loneliness, and that father-love absence affected loneliness levels through… More >

Muhannad J. Alshareef^*

Intelligent Automation & Soft Computing, Vol., , DOI:10.32604/iasc.2023.046722

Abstract Photovoltaic (PV) systems utilize maximum power point tracking (MPPT) controllers to optimize power output amidst varying environmental conditions. However, the presence of multiple peaks resulting from partial shading poses a challenge to the tracking operation. Under partial shade conditions, the global maximum power point (GMPP) may be missed by most traditional maximum power point tracker. The flower pollination algorithm (FPA) and particle swarm optimization (PSO) are two examples of metaheuristic techniques that can be used to solve the issue of failing to track the GMPP. This paper discusses and resolves all issues associated with using the standard FPA method as… More >

Lingjie Zhao, Cong Li^*

Energy Engineering, Vol., , DOI:10.32604/ee.2024.046918

Abstract The Miller cycle is a program that effectively reduces NOx emissions from marine diesel engines by lowering the maximum combustion temperature in the cylinder, thereby reducing NOx emissions. To effectively investigate the impact of Miller cycle optimum combustion performance and emission capability under high load conditions, this study will perform a one-dimensional simulation of the performance of a marine diesel engine, as well as a threedimensional simulation of the combustion in the cylinder. A 6-cylinder four-stroke single-stage supercharged diesel engine is taken as the research object. The chassis dynamometer and other related equipment are used to build the test system,… More >