Open Access

ARTICLE

Differential modulation of interleukin-6 expression by interleukin-1β in neuronal and glial cultures

Silvia Di Loreto, Rita Maccarone, Luigi Corvetti, Pierluigi Sebastiani, Daniela Piancatelli, Domenico Adorno

Istituto Trapianti d’Organo e Immunocitologia (ITOI), CNR, L’Aquila, Italy

* Corresponding Author: S. Di Loreto,

European Cytokine Network 2003, 14(2), 97-102.

Accepted 02 December 2002;

Abstract

We analysed the specific effects of IL-1β immunoneutralization on the expression of IL-6 in different pure cultures of neurones and glia after both experimental subliminal hypoxia and recovery. Whereas the IL-1β-deprivation signal induced a decrease in IL-6 expression and release of normoxic neurones, it provoked an increase in IL-6 protein in hypoxic neurones. Moreover, the direct correlation between IL-1β and IL-6, observed in normal and recovering neuronal cultures, was reversed in hypoxic conditions. These reversals were not observed in glial cells, in which IL-1β immunosuppression led to a decrease in IL-6 under all conditions considered. In conclusion, the IL-1β modulates IL-6 in different ways according to the ambient physiological or pathological conditions, and also acts via different mechanisms, depending on the cellular phenotype.

---

Keywords

---