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Carcinoembryonic antigen inhibits neutrophil activation by N-formyl-methionyl-leucyl-phenylalanine

Anna PAŃCZYSZYN1 *, Anna KROP-WATOREK1,2, Maciej WIECZOREK1

1 University of Opole, Department of Biotechnology and Molecular Biology, Opole, Poland
2 Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland

* Address correspondence to: Anna Pańczyszyn, email

BIOCELL 2015, 39(2-3), 1-4. https://doi.org/10.32604/biocell.2015.39.001

Abstract

Carcinoembryonic antigen (CEA) is a surface glycoprotein expressed in human epithelial cells and is released from their surface, especially during colorectal cancer. Frequently, colorectal cancer is accompanied by inflammation, where tumor-infiltrating neutrophils play an important role. CEA was also found to be a strong chemotactic agent for neutrophils. The purpose of this study was to find out if CEA can enhance neutrophil priming and activation. Primed neutrophils were activated by N-formyl-methionyl-leucyl-phenylalanine (formyl-MLP) and the resulting oxidative burst was measured luminometrically. Unexpectedly, in vitro priming of neutrophils by CEA, alone or preceded by LPS, inhibited subsequent activation of these cells by formyl-MLP. CEA may have anti-inflammatory properties in vivo.

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APA Style
PAŃCZYSZYN, A., KROP-WATOREK, A., WIECZOREK, M. (2015). Carcinoembryonic antigen inhibits neutrophil activation by n-formyl-methionyl-leucyl-phenylalanine. BIOCELL, 39(2-3), 1-4. https://doi.org/10.32604/biocell.2015.39.001
Vancouver Style
PAŃCZYSZYN A, KROP-WATOREK A, WIECZOREK M. Carcinoembryonic antigen inhibits neutrophil activation by n-formyl-methionyl-leucyl-phenylalanine. BIOCELL . 2015;39(2-3):1-4 https://doi.org/10.32604/biocell.2015.39.001
IEEE Style
A. PAŃCZYSZYN, A. KROP-WATOREK, and M. WIECZOREK "Carcinoembryonic antigen inhibits neutrophil activation by N-formyl-methionyl-leucyl-phenylalanine," BIOCELL , vol. 39, no. 2-3, pp. 1-4. 2015. https://doi.org/10.32604/biocell.2015.39.001



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