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Carcinoembryonic antigen inhibits neutrophil activation by N-formyl-methionyl-leucyl-phenylalanine

Anna PAŃCZYSZYN1 *, Anna KROP-WATOREK1,2, Maciej WIECZOREK1
1 University of Opole, Department of Biotechnology and Molecular Biology, Opole, Poland
2 Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
* Address correspondence to: Anna Pańczyszyn,

BIOCELL 2015, 39(2-3), 1-4. https://doi.org/10.32604/biocell.2015.39.001

Abstract

Carcinoembryonic antigen (CEA) is a surface glycoprotein expressed in human epithelial cells and is released from their surface, especially during colorectal cancer. Frequently, colorectal cancer is accompanied by inflammation, where tumor-infiltrating neutrophils play an important role. CEA was also found to be a strong chemotactic agent for neutrophils. The purpose of this study was to find out if CEA can enhance neutrophil priming and activation. Primed neutrophils were activated by N-formyl-methionyl-leucyl-phenylalanine (formyl-MLP) and the resulting oxidative burst was measured luminometrically. Unexpectedly, in vitro priming of neutrophils by CEA, alone or preceded by LPS, inhibited subsequent activation of these cells by formyl-MLP. CEA may have anti-inflammatory properties in vivo.

Keywords

CEA, oxidative burst, formyl-MLP

Cite This Article

PAŃCZYSZYN, A., KROP-WATOREK, A., WIECZOREK, M. (2015). Carcinoembryonic antigen inhibits neutrophil activation by N-formyl-methionyl-leucyl-phenylalanine. BIOCELL, 39(2-3), 1–4.



This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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