Open Access
ARTICLE
3-epi-bufotalin suppresses the proliferation in colorectal cancer cells through the inhibition of the JAK1/STAT3 signaling pathway
SANHUA LI1,2,#, QINGHONG KONG1,2,#, XIAOKE ZHANG1,2, XINTING ZHU1,3, CHUNBO YU3, CHANGYAN YU1,2, NIAN JIANG1,2, JING HUI1,2, LINGJIE MENG1,2,*, YUN LIU1,2,3,*
1 Guizhou Provincial College–Based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi, 563000, China
2 Life Science Institute of Zunyi Medical University, Zunyi, 563000, China
3 School of Preclinical Medicine of Zunyi Medical University, Zunyi, 563000, China
* Corresponding Authors: LINGJIE MENG. Email: ; YUN LIU. Email:
(This article belongs to this Special Issue: Recent Advancement in Cancer Molecular Signaling)
BIOCELL 2022, 46(11), 2425-2432. https://doi.org/10.32604/biocell.2022.019916
Received 24 October 2021; Accepted 06 April 2022; Issue published 07 July 2022
Abstract
Traditional Chinese medicine (TCM) has been increasingly employed in the last decades in China for both preventing and treating a variety of cancers. 3-
epi-bufotalin is an active ingredient of TCM “Chanpi” with anti-tumor potential. However, the effect and mechanism of 3-
epi-bufotalin on colorectal cancers were not well disclosed. The present study demonstrated that 3-
epi-bufotalin could reduce viability, trigger apoptosis, and block the cell cycle at the G
2/M stage in colorectal cancer cell lines HT29, RKO, and COLO205
in vitro. Moreover, 3-
epi-bufotalin inhibited the JAK1/STAT3 signaling pathway. These results indicated the anti-proliferation ability of 3-
epi-bufotalin in colorectal cancer cells.
Keywords
Cite This Article
LI, S., KONG, Q., ZHANG, X., ZHU, X., YU, C. et al. (2022). 3-
epi-bufotalin suppresses the proliferation in colorectal cancer cells through the inhibition of the JAK1/STAT3 signaling pathway.
BIOCELL, 46(11), 2425–2432.