Table of Content

Open Access

REVIEW

Effect of demethyltransferase FTO on tumor progression

LING SHENG1,2, YUEHONG SHEN1,2, HONGYU YANG1,2,*
1 School of Stomatology, Weifang Medical University, Weifang, 261035, China
2 Department of Oral and Maxillofacial Surgery, Shenzhen Hospital, Peking University, Shenzhen, 518036, China
* Corresponding Author: HONGYU YANG. Email:
(This article belongs to this Special Issue: Recent Advancement in Cancer Molecular Signaling)

BIOCELL 2022, 46(11), 2387-2397. https://doi.org/10.32604/biocell.2022.021032

Received 27 December 2021; Accepted 10 March 2022; Issue published 07 July 2022

Abstract

N6-methyladenosine (m6A) modification is the most widespread and conserved internal mRNA modification in mammalian cells. It greatly affects genetic regulation by enhancing the involvement of diverse cellular enzymes and thus, plays a significant role in basic life processes. Numerous studies on m6A modification identified FTO as a crucial demethylase that participates in various biological processes. Not only does FTO play a pivotal role in obesity-related conditions, but it also influences the occurrence, development, and prognosis of several cancers, such as acute myeloid leukemia, breast cancer, liver cancer, and lung cancer. Moreover, FTO also shows a close association with immunity and viral infections. This article summarized the molecular mechanism of FTO in tumorigenesis and tumor progression.

Keywords

m6A modification; Fat mass and obesity-associated protein; Molecular functional mechanism

Cite This Article

SHENG, L., SHEN, Y., YANG, H. (2022). Effect of demethyltransferase FTO on tumor progression. BIOCELL, 46(11), 2387–2397.



This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • 321

    View

  • 127

    Download

  • 0

    Like

Related articles

Share Link

WeChat scan