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Effect of demethyltransferase FTO on tumor progression


1 School of Stomatology, Weifang Medical University, Weifang, 261035, China
2 Department of Oral and Maxillofacial Surgery, Shenzhen Hospital, Peking University, Shenzhen, 518036, China

* Corresponding Author: HONGYU YANG. Email: email

(This article belongs to this Special Issue: Recent Advancement in Cancer Molecular Signaling)

BIOCELL 2022, 46(11), 2387-2397.


N6-methyladenosine (m6A) modification is the most widespread and conserved internal mRNA modification in mammalian cells. It greatly affects genetic regulation by enhancing the involvement of diverse cellular enzymes and thus, plays a significant role in basic life processes. Numerous studies on m6A modification identified FTO as a crucial demethylase that participates in various biological processes. Not only does FTO play a pivotal role in obesity-related conditions, but it also influences the occurrence, development, and prognosis of several cancers, such as acute myeloid leukemia, breast cancer, liver cancer, and lung cancer. Moreover, FTO also shows a close association with immunity and viral infections. This article summarized the molecular mechanism of FTO in tumorigenesis and tumor progression.


Cite This Article

SHENG, L., SHEN, Y., YANG, H. (2022). Effect of demethyltransferase FTO on tumor progression. BIOCELL, 46(11), 2387–2397.

cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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