Open Access
ARTICLE
Elp3 modulates neural crest and colorectal cancer migration requiring functional integrity of HAT and SAM domains
XIANGCAI YANG1,2,*, YA XU3, SHUTING MEI1, JIEJING LI3,*
1 Department of R&D, Biotech & Science Company of UP, Guangzhou Branch, Guangzhou, 510000, China
2 State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China
3 Laboratory of Developmental Disease and Natural Medicine, Medical Faculty, Kunming University of Science and Technology, Kunming, 650000, China
* Corresponding Authors:XIANGCAI YANG, ; JIEJING LI,
BIOCELL 2022, 46(2), 463-470. https://doi.org/10.32604/biocell.2021.014834
Received 03 November 2020; Accepted 23 December 2020; Issue published 20 October 2021
Abstract
Cell migration is a finely tuned biological process that often involves epithelial-mesenchymal transition (EMT).
EMT is typically characterized by the upregulation of mesenchymal markers such as Snail1. This process has been shown
to be of critical importance to normal developmental processes, including neural crest migration and invasion.
Interestingly, similar mechanisms are utilized in disease processes, such as tumor metastasis and migration. Notably,
EMT and EMT-like processes confer tumor cells with the ability to migrate, invade, and adopt stem cell-like
properties that largely account for immunosuppression and tumor recurrence. Therefore, identifying sensitive EMT
markers may contribute to cancer prognosis and diagnosis in many facets. Previously, we showed that Elp3 plays an
essential role during neural crest migration by stabilizing Snail1. In the current study, we further elucidate the
molecular mechanism underlying colorectal cancer migration. We found that mElp3 exerted an identical function to
xElp3 in modulating neural crest migration, and both HAT and SAM domains are imperative during this migratory
process. Interestingly, overexpression of mElp3 in SW480 cells promoted cell migration and invasion, and we further
showed that Elp3 stabilized Snail1 requiring integrity of both SAM and HAT domains. Our findings warrant further
exploration of the specific target of Elp3 in cancer cells.
Keywords
Cite This Article
YANG, X., XU, Y., MEI, S., LI, J. (2022). Elp3 modulates neural crest and colorectal cancer migration requiring functional integrity of HAT and SAM domains.
BIOCELL, 46(2), 463–470. https://doi.org/10.32604/biocell.2021.014834