Open Access iconOpen Access

REVIEW

crossmark

ER exit pathways and the control of proteostasis: Crucial role of the UPR, COPII, and ER-phagy in the secretory pathway

GIUSEPPINA AMODIO1, VALENTINA PAGLIARA1, PAOLO REMONDELLI1,*, ORNELLA MOLTEDO2

1 Dipartimento di Medicina, Chirurgia e Odontoiatria “Scuola Medica Salernitana”, Università degli Studi di Salerno, Baronissi, 84034, Italy
2 Dipartimento di Farmacia, Università degli Studi di Salerno, Fisciano, 84084, Italy

* Address correspondence to: Paolo Remondelli, email

BIOCELL 2022, 46(5), 1131-1137. https://doi.org/10.32604/biocell.2022.018638

Abstract

The endoplasmic reticulum (ER) is the site of entry of all proteins that function in the secretory pathway including the extracellular environment. Because it controls the folding of newly synthesized secretory proteins, the ER is indispensable for the maintenance of proteostasis in the secretory pathway. Within the ER and, in part, in post-ER compartments, the quality control of protein folding is under the regulation of the unfolded protein response (UPR) pathways. The UPR strategy is to enhance protein folding, increase the ER degradation pathway of misfolded proteins, and allow the exit from the ER of only correctly folded proteins. The latter is controlled by the multimeric complex COPII, which also provides some of the components for ER-phagy the only route for the disposal of protein aggregates. In this overview, we wish to contribute to the introduction of new perspectives in the study of the mechanisms underlying the control of proteostasis within the secretory pathway.

Keywords


Cite This Article

APA Style
AMODIO, G., PAGLIARA, V., REMONDELLI, P., MOLTEDO, O. (2022). ER exit pathways and the control of proteostasis: crucial role of the UPR, COPII, and er-phagy in the secretory pathway. BIOCELL, 46(5), 1131-1137. https://doi.org/10.32604/biocell.2022.018638
Vancouver Style
AMODIO G, PAGLIARA V, REMONDELLI P, MOLTEDO O. ER exit pathways and the control of proteostasis: crucial role of the UPR, COPII, and er-phagy in the secretory pathway. BIOCELL . 2022;46(5):1131-1137 https://doi.org/10.32604/biocell.2022.018638
IEEE Style
G. AMODIO, V. PAGLIARA, P. REMONDELLI, and O. MOLTEDO, “ER exit pathways and the control of proteostasis: Crucial role of the UPR, COPII, and ER-phagy in the secretory pathway,” BIOCELL , vol. 46, no. 5, pp. 1131-1137, 2022. https://doi.org/10.32604/biocell.2022.018638



cc Copyright © 2022 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • 2167

    View

  • 1382

    Download

  • 0

    Like

Share Link