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Current and future therapies for abnormal early embryogenesis with assisted reproductive technology

XIAOXIA WANG1,#, ZHONGYUAN YAO1,2,#, DI LIU1, CHUNHONG YU3,*, HUI LI1,3,*

1 Department of Reproductive Medicine, Xiangya Hospital, Central South University, Changsha, 410000, China
2 Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, 410078, China
3 Hunan Key Laboratory of Molecular Precision Medicine, Xiangya Hospital & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, 410000, China

* Corresponding Authors: CHUNHONG YU. Email: email; HUI LI. Email: email

(This article belongs to this Special Issue: Reproductive Health and Embryonic Development)

BIOCELL 2022, 46(8), 1803-1806. https://doi.org/10.32604/biocell.2022.019731

Abstract

Each stage of embryonic development, including normal gamete maturation, fertilization, zygotic genome activation, and cleavage, is crucial for human reproduction. Early embryo arrest is a common phenomenon. It is estimated that about 40%–70% of human embryos are arrested at early developmental stages. However, the exact mechanism remains largely uncertain. Embryos can be investigated in vitro by way of the development of in vitro fertilization/intracytoplasmic sperm injection. In addition to iatrogenic factors related to abnormal oocyte/embryo development, multiple gene mutations have been found to be involved in such phenotypes. Based on the knowledge of known etiological factors, several therapies are proposed to improve clinical outcomes. Here, we shed light on current and potential therapies for treating these conditions through reviewing articles and combining with our clinical and research experience.

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Cite This Article

WANG, X., YAO, Z., LIU, D., YU, C., LI, H. (2022). Current and future therapies for abnormal early embryogenesis with assisted reproductive technology. BIOCELL, 46(8), 1803–1806.



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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