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Exploring exosomes to provide evidence for the treatment and prediction of Alzheimer’s disease

XIANGYU QUAN1, XUETING MA1, GUODONG LI2, XUEQI FU1, JIANGTAO LI1, LINLIN ZENG1,*

1 Edmond H. Fischer Signal Transduction Laboratory, School of Life Sciences, Jilin University, Changchun, 130012, China
2 Department of General Surgery, The Second Hospital of Jilin University, Changchun, 130041, China

* Corresponding Author: LINLIN ZENG. Email: email

(This article belongs to the Special Issue: Novel Biomarkers in Diseases for Detection, Diagnosis, and Prognosis)

BIOCELL 2023, 47(10), 2163-2176. https://doi.org/10.32604/biocell.2023.031226

Abstract

Exosomes are extracellular vesicles with a 30–150 nm diameter originating from endosomes. In recent years, scientists have regarded exosomes as an ideal small molecule carrier for the targeted treatment of Alzheimer’s disease (AD) across the blood-brain barrier due to their nanoscale size and low immunogenicity. A large amount of evidence shows that exosomes are rich in biomarkers, and it has been found that the changes in biomarker content in blood, cerebrospinal fluid, and urine are often associated with the onset of AD patients. In this paper, some recent advances in the use of exosomes in the treatment of AD are reviewed, and various exosome markers and some latest detection methods are summarized to provide some evidence for the detection or treatment of AD by exosomes.

Graphical Abstract

Exploring exosomes to provide evidence for the treatment and prediction of Alzheimer’s disease

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APA Style
QUAN, X., MA, X., LI, G., FU, X., LI, J. et al. (2023). Exploring exosomes to provide evidence for the treatment and prediction of alzheimer’s disease. BIOCELL, 47(10), 2163-2176. https://doi.org/10.32604/biocell.2023.031226
Vancouver Style
QUAN X, MA X, LI G, FU X, LI J, ZENG L. Exploring exosomes to provide evidence for the treatment and prediction of alzheimer’s disease. BIOCELL . 2023;47(10):2163-2176 https://doi.org/10.32604/biocell.2023.031226
IEEE Style
X. QUAN, X. MA, G. LI, X. FU, J. LI, and L. ZENG "Exploring exosomes to provide evidence for the treatment and prediction of Alzheimer’s disease," BIOCELL , vol. 47, no. 10, pp. 2163-2176. 2023. https://doi.org/10.32604/biocell.2023.031226



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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