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Molecular basis of COVID-19, ARDS and COVID-19-associated ARDS: Diagnosis pathogenesis and therapeutic strategies

PRIYADHARSHINI THANJAVUR SRIRAMAMOORTHI1,2, GAYATHRI GOPAL1,2, SHIBI MURALIDAR1,2, SAI RAMANAN ESWARAN1,2, DANUSH NARAYAN PANNEERSELVAM1,2, BHUVANESWARAN MEIYANATHAN1,2, SRICHANDRASEKAR THUTHIKKADU INDHUPRAKASH1,2, SENTHIL VISAGA AMBI1,2,*

1 Biopharmaceutical Research Lab, Anusandhan Kendra-1, SASTRA Deemed-to-be University, Thanjavur, 613401, India
2 School of Chemical and Biotechnology, SASTRA Deemed-to-be University, Thanjavur, 613401, India

* Corresponding Author: SENTHIL VISAGA AMBI. Email: email

(This article belongs to the Special Issue: The aberrant signaling cascade transduction during disease development )

BIOCELL 2023, 47(11), 2335-2350. https://doi.org/10.32604/biocell.2023.029379

Abstract

The novel coronavirus pneumonia (COVID-19) is spreading worldwide and threatening people greatly. The routes by which SARS-CoV-2 causes lung injury have grown to be a major concern in the scientific community since patients with new Coronavirus, severe acute respiratory syndrome coronavirus (SARS-CoV-2) have a high likelihood of developing acute respiratory distress syndrome (ARDS) in severe cases. The mortality rate of COVID-19 has increased over the period due to rapid spread, and it becomes crucial to understand the disease epidemiology, pathogenic mechanisms, and suitable treatment strategies. ARDS is a respiratory disorder and is one of the clinical manifestations observed in patients with severe COVID-19. In this scenario, it is important to address this problem to develop suitable treatment strategies. This review attempts to present the prevalence of ARDS in COVID-19 patients and their predictive causes and risk factors, highlighting the contrasting features of COVID-19-induced ARDS with typical ARDS. This review also presents insights into the association between SARS-CoV-2 and lung damage while exploring the potential COVID-19 mechanisms in ARDS from the perspective of the angiotensin-converting enzyme 2 protein, cytokine storm, immune responses, and other signaling pathways. The review also discusses the diagnosis strategies, pathogenesis, risk factors, and treatment options of COVID-19-related ARDS.

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Molecular basis of COVID-19, ARDS and COVID-19-associated ARDS: Diagnosis pathogenesis and therapeutic strategies

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APA Style
SRIRAMAMOORTHI, P.T., GOPAL, G., MURALIDAR, S., ESWARAN, S.R., PANNEERSELVAM, D.N. et al. (2023). Molecular basis of COVID-19, ARDS and covid-19-associated ARDS: diagnosis pathogenesis and therapeutic strategies. BIOCELL, 47(11), 2335-2350. https://doi.org/10.32604/biocell.2023.029379
Vancouver Style
SRIRAMAMOORTHI PT, GOPAL G, MURALIDAR S, ESWARAN SR, PANNEERSELVAM DN, MEIYANATHAN B, et al. Molecular basis of COVID-19, ARDS and covid-19-associated ARDS: diagnosis pathogenesis and therapeutic strategies. BIOCELL . 2023;47(11):2335-2350 https://doi.org/10.32604/biocell.2023.029379
IEEE Style
P.T. SRIRAMAMOORTHI et al., "Molecular basis of COVID-19, ARDS and COVID-19-associated ARDS: Diagnosis pathogenesis and therapeutic strategies," BIOCELL , vol. 47, no. 11, pp. 2335-2350. 2023. https://doi.org/10.32604/biocell.2023.029379



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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