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Mesenchymal stem cells and the angiogenic regulatory network with potential incorporation and modification for therapeutic development

VAN THI TUONG NGUYEN1,2, KHUONG DUY PHAM1,2,3, HUONG THI QUE CAO1,2, PHUC VAN PHAM1,2,*

1 Stem Cell Institute, University of Science Ho Chi Minh City, Ho Chi Minh City, Viet Nam
2 Viet Nam National University Ho Chi Minh City, Ho Chi Minh City, Viet Nam
3 Laboratory of Stem Cell Research and Application, University of Science Ho Chi Minh City, Ho Chi Minh City, Viet Nam

* Corresponding Author: PHUC VAN PHAM. Email: email

(This article belongs to the Special Issue: Perspectives on Stem Cells and Regenerative Medicine)

BIOCELL 2024, 48(2), 173-189. https://doi.org/10.32604/biocell.2023.043664

Abstract

Mesenchymal stem cells (MSCs) have been proposed in regenerative medicine, especially for angiogenic purposes, due to their potential to self-renew, differentiate, and regulate the microenvironment. Peripheral vascular diseases, which are associated with reduced blood supply, have been treated but not cured. An effective therapy is to recover blood supply via vessel regeneration in the affected area, and MSCs appear to be promising for such conditions. Several studies aimed to explore the role of MSCs in performing angiogenesis and have revealed numerous potential methods to enhance MSC capacity in vessel formation. Efforts have been made to modify standard MSCs to optimize their prospective characteristics. Thus, understanding the mechanism underlying MSC angiogenic potential, and learning how to control their effect in the in vivo environment is critical for success in clinical settings. This review covers the angiogenesis process and discusses the role of some of the key angiogenic regulators. Possible techniques to enhance the angiogenic capacity of MSCs are also mentioned to suggest potential methods for therapeutic application.

Graphic Abstract

Mesenchymal stem cells and the angiogenic regulatory network with potential incorporation and modification for therapeutic development

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APA Style
NGUYEN, V.T.T., PHAM, K.D., CAO, H.T.Q., PHAM, P.V. (2024). Mesenchymal stem cells and the angiogenic regulatory network with potential incorporation and modification for therapeutic development. BIOCELL, 48(2), 173-189. https://doi.org/10.32604/biocell.2023.043664
Vancouver Style
NGUYEN VTT, PHAM KD, CAO HTQ, PHAM PV. Mesenchymal stem cells and the angiogenic regulatory network with potential incorporation and modification for therapeutic development. BIOCELL . 2024;48(2):173-189 https://doi.org/10.32604/biocell.2023.043664
IEEE Style
V.T.T. NGUYEN, K.D. PHAM, H.T.Q. CAO, and P.V. PHAM "Mesenchymal stem cells and the angiogenic regulatory network with potential incorporation and modification for therapeutic development," BIOCELL , vol. 48, no. 2, pp. 173-189. 2024. https://doi.org/10.32604/biocell.2023.043664



cc Copyright © 2024 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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