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Identifying Driver Genes Mutations with Clinical Significance in Thyroid Cancer

Hyeong Won Yu1, Muhammad Afzal2, Maqbool Hussain2, Hyungju Kwon3, Young Joo Park4, June Young Choi1,*, Kyu Eun Lee5

1 Department of Surgery, Seoul National University Bundang Hospital, Seongnam-si, Korea
2 Department of Software, Sejong University, Seoul, Korea
3 Department of Surgery, College of Medicine, Ewha Womans University, Seoul, Korea
4 Department of Internal Medicine, Seoul National University Hospital and College of Medicine, Seoul, Korea
5 Department of Surgery, Seoul National University Hospital and College of Medicine, Seoul, Korea

* Corresponding Author: June Young Choi. Email: email

(This article belongs to this Special Issue: Machine Learning-based Intelligent Systems: Theories, Algorithms, and Applications)

Computers, Materials & Continua 2021, 67(1), 1241-1251.


Advances in technology are enabling gene mutations in papillary thyroid carcinoma (PTC) to be analyzed and clinical outcomes, such as recurrence, to be predicted. To date, the most common genetic mutation in PTC is in BRAF kinase (BRAF). However, whether mutations in other genes coincide with those in BRAF remains to be clarified. The aim of this study was to find mutations in other genes that co-exist with mutated BRAF, and to analyze their frequency and clinical relevance in PTC. Clinical and genetic data were collected from 213 PTC patients with a total of 36,572 mutation sites in 735 genes. After matching with genes from PTC entries in a global database (NCBI Gene), 69 genes with mutations in coding regions were chosen for further study. Through frequency-based analysis, we identified commonly mutated genes co-existing with mutated BRAF and, using the mutation count correlation matrix (MCCM) method, analyzed their incidence according to age and gender. We designed Chord diagrams to reveal gene relationships concerning age and gender, and found that mutations in ALK, ATM, COL1A1, MSTIR, PRKCA, and WNK1 most commonly coincide with mutated BRAF, followed by APC, AURKA, and AURKB. These findings provide further insight into the genetic profile of PTC.


Cite This Article

H. Won Yu, M. Afzal, M. Hussain, H. Kwon, Y. Joo Park et al., "Identifying driver genes mutations with clinical significance in thyroid cancer," Computers, Materials & Continua, vol. 67, no.1, pp. 1241–1251, 2021.

cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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