Open Access
ARTICLE
Optimization of Chemically Reactive Radiative MHD Casson Hybrid Nanofluid Flow over a Time-Dependent Stretching Surface Using Response Surface Methodology and ANOVA
1 Department of Mathematics, Koneru Lakshmaiah Education Foundation, Green Fields, Vaddeswaram, Andhra Pradesh, India
2 Department of Mathematics, Vignan’s Nirula Institute of Technology and Science for Women, Guntur, Andhra Pradesh, India
3 Department of Industrial Systems and Technologies Engineering, University of Parma, Parma, Italy
* Corresponding Author: Giulio Lorenzini. Email:
Fluid Dynamics & Materials Processing 2026, 22(8), 3 https://doi.org/10.32604/fdmp.2026.083129
Received 30 March 2026; Accepted 17 June 2026; Issue published 04 September 2026
Abstract
This study examines transient heat and mass transfer characteristics in a Casson-based hybrid nanofluid (Au–Cu/water) flowing over a time-dependent stretching elastic surface in the presence of porous media and viscous dissipation. The mathematical model further incorporates the effects of magnetic fields, thermal radiation, chemical reactions, and velocity slip conditions to capture realistic transport phenomena encountered in advanced thermal systems. Through suitable similarity transformations, the governing partial differential equations are reduced to a system of nonlinear ordinary differential equations, which are solved numerically using the MATLAB bvp4c solver. To identify optimal operating conditions, Response Surface Methodology (RSM) is employed to develop predictive correlations for skin-friction coefficient, heat transfer rate, and mass transfer rate. The statistical significance and adequacy of the developed models are assessed using Analysis of Variance (ANOVA). Validation against previously published results demonstrates excellent agreement, confirming the accuracy and robustness of the proposed formulation. The results reveal that variations in the magnetic field substantially modify the Lorentz force distribution, leading to pronounced changes in the velocity, temperature, and concentration profiles. Furthermore, magnetic field strength, slip effects, and hybrid nanofluid properties significantly influence surface shear stress, thermal transport, and concentration boundary-layer development. The RSM optimization framework successfully identifies parameter combinations that maximize heat and mass transfer performance while controlling frictional resistance.Keywords
There are many different types of engineering devices, including electrodes for heat transfer and fuel cells, that require fluids in order to increase the amount of heat that is transmitted through them. In order to provide a more precise explanation of the movement of a particular fluid, models that are utilized in the study of fluid flow are constructed. According to the research that has been done, these structures are categorized as either Newtonian or non-Newtonian fluids studied by Lu et al. [1]. There are a few fundamental laws, such as Fourier’s and Fick’s, that play an important part in fluid movement issues. Rauf et al. [2] have focused a large amount of emphasis on the movement and transport processes of non-Newtonian fluids. This is due to the fact that non-Newtonian fluids have an extensive variety of applications in the disciplines of industry, biology, technology, and chemistry. Among these are flow tracers, increased capacity, a component of friction in oil pipelines, and several cooling and heating systems examined by Khan et al. [3]. In the fields of mechanical engineering, business, and manufacturing, non-Newtonian materials have become more common than Newtonian ones in the last several decades. This is because, according to research by Abbas et al. [4], non-Newtonian fluids predict elastic characteristics more accurately than Newtonian fluids because they exhibit significant viscoelastic behavior. It is also well known that the majority of physiological fluids behave differently from Newtonian fluids.
The extraordinary thermal properties and potential medicinal uses of nanofluids have sparked a never-ending stream of research into these materials. Nanofluids may be used in place of more traditional fluids due to research showing that they are more effective heat transfer agents. Many researchers have shifted their attention to researching small fluids because of their superior thermal performance. Nanoparticles distinguish themselves from other fluid types and give them a competitive advantage due to their better thermal conductivity. Medical, transportation, electronics, food, and energy production are just a few of the many industries that rely on them because of this property. Choi & Eastman [5] further claim that the original liquids’ conductivity properties improve with the introduction of these nanoparticles, which may be anywhere from one nanometre to one hundred nanometres in size. The results of the studies stated earlier support this. Improving particle properties, including size, medicinal content, and overall structure, can enhance their usefulness in numerous biomedical research sectors. Said et al. [6] research into the preparation of nanofluids has begun at both the industrial and academic levels, following the new door that the concept of nanofluids opened. Surface roughness for condensation flow inside microchannels was investigated by Rashidi et al. [7]. Nanofluids, as discussed by Jazaa et al. [8], are of paramount importance because of the vast range of industries that rely on them and the tremendous heat transmission capabilities they possess.
Hybrid nanofluids have recently supplanted conventional nanofluids due to their substantially higher capabilities for heat transfer. An analysis of nanofluid/hybrid nanofluid for improved heat transmission was conducted by Guo et al. [9]. Narankhishig et al. [10] reviewed many nanofluids (NFs) features related to convective heat transfer, with an emphasis on the function of magnetism in improving heat transfer. There are several possible benefits and uses for hybrid nanofluids, which have piqued the curiosity of researchers. Heat transfer efficiency and thermophysical properties are best achieved by hybrid nanofluids (HNFs) that combine several nanoparticles, as opposed to single-phase NFs [11,12]. Naganthran et al. [13] have taken a keen interest in hybrid nanofluids as a result of the wide variety of processes they use in a broad spectrum of scientific, industrial, and biological fields. An intriguing new option is hybrid nanofluids, which, because of their unusual makeup, have better thermal characteristics than competing materials. These materials have the potential to recover the capacity for heat transmission and thermal conductivity through the combined action of two sorts of nanoparticles, non-metallic and non-ferromagnetic, scattered in a standard fluid. Scientists and investigators from all around the world have taken to using the hybrid nanofluid model in their work. Research on the intricate rheological characteristics of non-Newtonian hybrid nanofluids may be conducted using a variety of distinct methods. The following kinds of fluids are known: Maxwell (Haneef et al. [14]), Casson (Gohar et al. [15]), Williamson (Rashad et al. [16]), Viscoelastic (Ummeda & Ontela [17]), Micropolar (Gumber et al. [18]), Jeffery (Asjad et al. [19]), Sutterby (Khan et al. [20]), and so on. Small gold particles were examined by Ellahi et al. [21] in their inquiry into the peristaltic blood-flowing behavior of catheters with pliable walls and two stress fluids.
The development of efficient, temperature-sensitive medication delivery devices depends on our ability to comprehend the behavior of nanofluids in porous media. Akbar et al. [22] studied the wave-like motion created by the cyclic motion of the ducts’ ability to contract and expand when their walls are flexible to move fluid. In engineering and physiology, this system plays a significant role in assisting digestion, slurry movement, and blood circulation. Important products like tube pumps and medical equipment use peristaltic motion to manage fluid transfer precisely. The intricacies of peristaltic flow have been the subject of mathematical investigations, which consider various fluid kinds and duct designs. Using an exponentially stretched sheet, by adding copper (Cu) and gold (Au) nanoparticles, Madiha Takreem et al. [23] investigate the flow behavior of a blood-based Casson HNF. Vishalakshi et al. [24] and Chahregh and Dinarvand [25] have shown that porous structures have the potential to greatly impact thermal performance and flow resistance. Rauf et al. [26] investigated the mass and heat transfer properties of a boundary layer of a two-dimensional mixed convective Maxwell nanofluid across a porous linearly stretched surface in the presence of an external magnetic field. The Dufour and Soret phenomena, together with the effects of thermal radiation, were also involved in the research. Heat systems that make use of hybrid nanofluids to work more efficiently were one of the 18 engineering domains studied by Hanif et al. [27]. Habib et al. [28] analyzed the impacts of thermal radiation on porous surfaces on the temperature transfer and flow properties of hybrid nanofluids composed of Graphene nanotubes with one or more walls. For the purpose of analyzing fluid flow issues, several methods, geometries, and assumptions have been put forward over the past many decades. Magnetohydrodynamic (MHD) fluid movement with a boundary layer conducting is one of the components. Khan [29] examined the impacts of a magnetic field on the movement of molybdenum disulfide nanofluids used in heat transfer enhancement treatments. The mixed convection motion in a square enclosure using a magnetic field was also investigated by Chamkha & Ismael [30]. Mabood et al. [31] detailed the many physical characteristics of a nanofluid that combines water and other substances, and studied the behavior of these qualities change when exposed to heat. A lot of investigation has been focused on the impacts of thermal radiation on the dynamics of the transmission of heat inside the hybrid nanofluid flows. In their study, Shatnawi et al. [32] investigated the behavior of magnetic and nonlinear radiation impacting the movement of Casson fluid in a hybrid nanofluid. The entropy production of nanofluid flows across heated sheets influenced by viscous dissipation and thermal radiation using the RSM technique was discussed in detail in [33,34].
Environmental management, biochemistry, food processing, atmospheric dynamics, and freezing damage reduction in crops are just a handful of the several fields that rely heavily on chemical interactions. When species exist in distinct phases of a system or at interfaces, it becomes very difficult to account for their molecular diffusion. Investigating the consequences of heat production, thermal radiation, and chemical processes, Agbaje and Leach [35] examined a viscoelastic Jeffrey NF’s natural convectional descent through the porous surface. Fatunmbi and Salawu [36] discussed chemical reaction-induced micropolar nanofluid flow, mass flux, and multiple slip hybrid nanofluid flow. Ramzan et al. [37] investigated the thermophysical characteristics of the Casson fluid movement on an inclined surface. Several impacts, such as Dufour, Soret, and chemical reactions, were investigated in this study.
Viscous dissipation, sometimes called frictional heating, is the energy transfer from motion to heat in a fluid when it is subjected to forces that are both viscous and mechanically strong. The boundary sheet flow, which is formed when a surface is either shrunk or stretched, has many practical uses throughout the manufacturing and industrial phases, such as continuous glass casting, wire drawing, and metal or polymer extrusions [38]. Alzahrani et al. [39] investigated the viscosity effect of Casson fluid flow over a rotating tube. Alali and Megahed [40] formulated the notion of MHD Casson nanofluid concerning viscous dissipation in a liquid film over a stretching sheet, incorporating heat radiation and slip effects. Devi and Devi [41] developed the concept of augmenting heat transfer in hybrid nanofluid flow across an elongating sheet.
Gaps between This Study and Existing Literature
Current research indicates that there has been no examination of the two-dimensional time-dependent dynamics of a novel non-Newtonian system, which integrates Casson-type fluid flow of a hybrid nanofluid comprising gold and copper with water as the base fluid, through the stretched permeability of a porous medium. Consequently, the proposed research constitutes a vital strategy to bridge this gap and encourages academics to create an innovative methodology for examining the flow, temperature, and concentration distribution behavior over a stretched sheet. This research effectively examines the physical factors and their effects on the flow, thermal, and concentration properties of a hybrid nanoparticle-water fluid system over a stretched sheet within a permeable porous medium, utilizing numerical techniques, graphical representations, and tables. This comprehensive framework captures the interplay between nanoscale particle dynamics, slip effects, and stochastic electromagnetic forces, advancing the predictive modeling of nanofluid boundary layers with direct applications in thermal management, coating, materials processing, and biomedical engineering.
2 Formulation of the Physical System
This work aims to analyze the time-dependent dynamics of a novel hybrid non-Newtonian nanofluid system, which integrates a Casson base fluid, characterized by a Γ factor, with dual nanoparticle suspensions of copper (Cu) and gold (Au). An external field with a strength of
For the base fluid, the kinematic viscosity is denoted as
Figure 1: A schematic representation of the physical model.
2.1 Dimensional Analysis Framework
The four coupled conservation principles that mathematically describe the system’s dynamics are mass balance (continuity), momentum transport with non-Newtonian effects, energy transfer with radiative heat flux and thermal slip boundary conditions, and species transport with reaction kinetics. Within the specified physical limits, this formulation accurately depicts the interaction of hydrodynamics, heat, and chemical processes (Devi and Devi [41]):
The dimensional temperature (T), diffusion coefficient
2.2 Physical System Boundary Definitions
Crucial interfacial phenomena driving fluid-wall interactions are captured by formally defining the domain’s boundary constraints. Three crucial physical phenomena are included in these mathematically determined conditions: momentum slip, thermal slip, and solutal slip at the boundary surface. Their strict application guarantees that the solutions to the governing equations are physically compatible with the behavior of systems in the real world. A mathematical summary of these phenomena is:
The suction velocity, denoted as
2.3 Canonical Dimensionless Quantities
We simplify the governing partial differential equations by applying a similarity transformation that captures the inherent scaling behavior of the boundary layer flow, thereby reducing these equations to a more manageable set of ordinary differential equations. Both transformations work together to reduce system complexity. There are three major benefits to this approach: better numerical stability due to the elimination of unit dependency, more physical understanding through characteristic parameter ratios, and easier pattern recognition in solution behavior. The full nondimensionalization process is described in the section that follows, which involves methodically obtaining each transformed equation from its dimensional equivalent. This method relies on the following structure (Devi and Devi [41]).
2.4 Similarity-Transformed Equation Set
Both the characteristic scaling method and the system complexity reduction and the universalization of conclusions for broader physical interpretation are essential analytical aims of the transformation to dimensionless form. The key dynamics of the governing equations are revealed by introducing normalized variables, which in turn disclose the dominant dimensionless groups that drive the mechanisms of flow, thermal and mass transport. The transformed system, which includes the boundary restrictions and the ordinary differential equations, is a generalized form that may be applied to other scales and different types of operations. The improved mathematical foundation that underpins our following analysis is presented below:
These formulas comprise the boundary edge conditions:
The eight main control variables that govern the coupled transport phenomena are shown by the parametric analysis. These include the following: the magnetic field factor M, which modifies Lorentz forces; permeability of porous media
The momentum contour, thermal contour, and concentration contours for various values of the controlling parameters are the main quantities of interest in this investigation. In addition, accurate characterization of surface behavior and boundary layer structure is vital for engineering and industrial applications involving Casson-type hybrid nanofluid movement and thermal transport, such as advanced cooling technologies, materials processing, and magnetically guided drug delivery. To this end, it is important to quantify the heat, mass and momentum transfer at the linearly stretching surface. The nondimensional parameters of practical relevance include the coefficient of skin friction
2.5.1 Skin Friction Coefficient
The coefficient of skin friction
The local Nusselt number
Similarly, the local Sherwood number
The solution of the current analysis is obtained by implementing the bvp4c code with respect to related boundary constraints. The Lobato scheme is used on the base of the finite difference method.
The MATLAB software built-in code is used here.
The corresponding equations take the form of
In the above equations, the subscripts a and b represent the equivalent constraints at
Figure 2: Flow chart of solution and optimization technique procedure.
Table 1: Thermophysical features of nanoparticles and base fluid [Shaiq [42]].
| Properties | Cu | Au | Water |
|---|---|---|---|
| ρ (kg/m3) | 8933 | 19,300 | 997.1 |
| Cp (J/kg·k) | 385 | 129 | 4179 |
| k (W/m·k) | 386 | 318 | 0.613 |
| σ | 5.96 × 107 | 4.1 × 107 | 0.05 |
| Pr | - | - | 6.2 |
Table 2: Physical thermo properties of HNF (Cu-Au/Water) (Shaiq [42]).
| Properties | HNF (Cu-Au/Water) |
|---|---|
| Density (ρ) | |
| Viscosity (μ) | |
| Heat Capacity | |
| Thermal conductivity (k) | |
| Electrical Conductivity |
Numerical comparison with current numerical results is done to confirm the accuracy of the generated simulator. Devi & Devi [41] reported in the literature for relevant limiting cases. We implement those problems in our simulator and calculate heat transfer. We present the generated data by our simulator and the existing data available in the literature in Table 3. Numerical outcomes for heat transfer rate in terms of
Table 3: Values of −θ(0) for distinct values of Pr when
| Pr | Present Study | Devi & Devi [41] |
|---|---|---|
| 20.0 | 3.352000 | 3.35390 |
| 2.00 | 0.910035 | 0.91135 |
| 6.13 | 1.749682 | 1.75968 |
| 7.00 | 1.895399 | 1.89540 |
The numerical results obtained by solving the transformed system of nonlinear ordinary differential equations regulating the nanofluid flow over a linearly stretching sheet are presented and analyzed in this section using graphs. The influence of the physical constraints, such as Casson parameter
The effect of M on momentum and thermal distribution is depicted in Fig. 3 and Fig. 4. When the magnetic field is stronger, the Lorentz force is increased, which diminishes fluid movement and lowers momentum while also snowballing the efficiency of thermal energy dissipation. As a result of the Ohmic heating impacts that enhance the MHD heating mechanism, Joule heating is responsible for a significant surge in the temperature profile. In general, this suppression of momentum upsurges the thermal boundary sheet, thickness, which results in an upsurge in the thermal of the fluid near the surface due to a declination of convective heat transfer. An upsurge in the value of M results in a decline in fluid flow and a rise in thermal, both of which negatively impact the heat transfer rate within the system. In border layer flows, the Lorentz force also influences a species’ solutal contour, especially in Magnetohydrodynamic (MHD) flows, which are studied in Fig. 5 and involve the interaction of a fluid that conducts electricity with a magnetic field. It is evident from this graph that the Lorentz force tends to cause the concentration boundary sheet to thicken. The species diffuses deeper into the fluid before reaching the free-stream solutal because of the decreased velocity. Finally, as M values increase, the solutal contour declines.
Figure 3: Fluctuations of M on
Figure 4: Fluctuations of M on
Figure 5: Fluctuations of M on
The porosity parameter
Figure 6: Fluctuations of Kp on
Figure 7: Fluctuations of Kp on
Fig. 8 demonstrates that raising the porous medium constraint
Figure 8: Fluctuations of Kp on
Fig. 9 depicts the difference of
Figure 9: Fluctuations of
Fig. 10 exemplifies the impact of the Casson constraint
Figure 10: Fluctuations of
Fig. 11 displays the effect of the Casson parameter
Figure 11: Fluctuations of
The fluid’s velocity is significantly decelerated by the unsteadiness constraint
Figure 12: Fluctuations of
Figure 13: Fluctuations of
Figure 14: Fluctuations of
Fig. 15 displays a decreasing trend in the momentum contour as a function of the momentum slip constraint
Figure 15: Fluctuations of
Figure 16: Fluctuations of
Figure 17: Fluctuations of
The velocity change with suction constraint
Figure 18: Fluctuations of
Fig. 19 exemplifies the effect of the temperature radiation parameter (Rd) on the thermal contour
Figure 19: Fluctuations of Rd on
Fig. 20 illustrates the impact of the viscous dissipation constraint Ec on the thermal contours. Physically, viscous dissipation in the boundary layer represents Kinetic energy conversion for moving fluid into internal thermal energy due to the viscous fluid friction within the fluid layers. Moreover, the viscous-dissipation source term appears in the energy equation in our problem of interest, and thereby the increased value of viscous dissipation parameter Ec raises the fluid thermal and increases the temperature border sheet.
Figure 20: Fluctuations of Ec on
A reduction in the thermal contour is exemplified in Fig. 21, which displays thermal contours for a range of Prandtl number (Pr) values (3–10) as Pr increases. As Prandtl numbers upsurges, thermal contours that are physically smaller are formed. When it comes to practical applications, selecting a fluid on the basis of its Prandtl number value is of the utmost importance in order to get the best possible thermal performance. To give an example, in systems that necessitate effective surface cooling, oils with high the impact of the changing magnetic field and the Prandtl number on the thermal and movement behavior of Cu-Au/water HNFs in porous media is inspected in this study. The variable magnetic field is essential in MHD because it has the ability to affect the flow of fluid by modifying the momentum contour, minimizing turbulence, and changing the way that heat is transferred. It is particularly helpful in applications such as reactors and electronic cooling, where controlling the magnetic field is essential to the management of temperature and movement properties. The Prandtl number is an important variable because it symbolizes the balance between thermal contour and momentum contour in a fluid. The study is able to signify the ways in which modifications to the properties of fluids have an impact on heat transport by employing a variable Prandtl number. Heat transfer is improved when the temperature boundary sheet is narrower, as indicated by a low Prandtl value. Conversely, a high Prandtl number results in a bigger thermal boundary layer, which lowers heat transmission efficiency.
Figure 21: Fluctuations of Pr on
Fig. 22 displays the concentration curve of
Figure 22: Fluctuations of Sc on
Figure 23: Fluctuations of Cr on
The skin-friction factor is revealed in Fig. 24 as a function of M and
Figure 24: Impact on skin friction with M and
Figure 25: Impact on Nusselt number with M and
Figure 26: Impact on Sherwood number with M and
Figure 27: Impact on Nusselt number with Rd and
Figure 28: Impact on Sherwood number with Cr and
5 Optimization Analysis Using Response Surface Method
In the MHD flow of Casson hybrid nanofluid, the RSM was used to improve the efficiency of heat and mass transfer as well as skin friction factors. The results showed that, especially at low levels of thermal radiation, the sensitivity of heat and mass movement decreased as important parameters increased. Additionally, a greater Forchheimer parameter increased the sensitivity of the friction factor rate, whereas the Casson-fluid parameter showed the opposite effect.
5.1 Response Surface Regression: Cfx Versus M, Kp and λ1
Overview of the model
| S | R2 | R2 (Adj.) | R2 (Pred.) |
| 0.0066002 | 99.99% | 99.99% | 98.98% |
Variance examination
| Source | DF | Adj. SS | Adj. MS | F-Value | p-Value |
| Model | 9 | 22.2993 | 2.4777 | 56,876.36 | 2.4 × 10−22 |
| Linear | 3 | 21.5777 | 7.1926 | 165,107.35 | 9.1 × 10−24 |
| M | 1 | 0.0420 | 0.0420 | 963.33 | 2.8 × 10−11 |
| Kp | 1 | 0.0306 | 0.0306 | 702.93 | 1.3 × 10−10 |
| 1 | 21.5051 | 21.5051 | 493,655.79 | 8.4 × 10−25 | |
| Square | 3 | 0.7085 | 0.2362 | 5421.01 | 2.4 × 10−16 |
| M ∗ M | 1 | 0.0000 | 0.0000 | 0.91 | 0.363 |
| Kp ∗ Kp | 1 | 0.0000 | 0.0000 | 0.51 | 0.491 |
| 1 | 0.3979 | 0.3979 | 9133.86 | 3.9 × 10−16 | |
| 2-Way Interaction | 3 | 0.0132 | 0.0044 | 100.71 | 9.0 × 10−8 |
| M ∗ Kp | 1 | 0.0004 | 0.0004 | 8.51 | 0.015 |
| M ∗ | 1 | 0.0074 | 0.0074 | 169.74 | 1.3 × 10−7 |
| Kp ∗ | 1 | 0.0054 | 0.0054 | 123.87 | 5.9 × 10−7 |
| Error | 10 | 0.0004 | 0.0000 | ||
| Lack-of-Fit | 5 | 0.0004 | 0.0001 | * | * |
| Pure Error | 5 | 0.0000 | 0.0000 | ||
| Total | 19 | 22.2997 | |||
| *: not applicable (NA). |
Regression equation
A response surface regression analysis was conducted in order to evaluate the effect of various parameters on the skin friction coefficient in Fig. 29. The analysis revealed a highly accurate model, achieving an R2 value of 99.99%, a modified R2 of 99.99% and an anticipated R2 of 98.98%, illustrating a strong correlation between the predicted and actual results. The ANOVA findings validated the model’s significance, with an overall F-value of 56,876.36 and a p-value below 0.0001, confirming its reliability. The linear effects of M (F = 963.33, p = 2.8 × 10−11), Kp (F = 702.93, p = 1.3 × 10−10) and
Figure 29: Residual analysis plots for the skin-friction coefficient (
Figure 30: (Color online) contour plot of
Figure 31: (Color online) surface plot of
Figure 32: (Color online) contour plot of
Figure 33: (Color online) surface plot of
5.2 Response Surface Regression: Nux Versus Rd, Ec, λ2
Model Summary
| S | R2 | R2 (Adj.) | R2 (Pred.) |
| 0.369036 | 99.75% | 99.53% | 97.67% |
Analysis of variance
| Source | DF | Adj. SS | Adj. MS | F-Value | p-Value |
| Model | 9 | 546.741 | 60.749 | 446.07 | 8.0 × 10−12 |
| Linear | 3 | 456.192 | 152.064 | 1116.58 | 6.3 × 10−13 |
| Rd | 1 | 58.111 | 58.111 | 426.70 | 1.6 × 10−9 |
| Ec | 1 | 8.738 | 8.738 | 64.16 | 1.2 × 10−5 |
| 1 | 389.343 | 389.343 | 2858.88 | 1.3 × 10−13 | |
| Square | 3 | 70.790 | 23.597 | 173.27 | 6.4 × 10−9 |
| Rd ∗ Rd | 1 | 0.009 | 0.009 | 0.07 | 0.797 |
| Ec ∗ Ec | 1 | 0.002 | 0.002 | 0.01 | 0.922 |
| 1 | 39.973 | 39.973 | 293.52 | 9.7 × 10−9 | |
| 2-Way Interaction | 3 | 19.759 | 6.586 | 48.36 | 2.9 × 10−6 |
| Rd ∗ Ec | 1 | 0.458 | 0.458 | 3.36 | 0.097 |
| Rd ∗ | 1 | 16.324 | 16.324 | 119.87 | 6.9 × 10−7 |
| Ec ∗ | 1 | 2.977 | 2.977 | 21.86 | 0.000874 |
| Error | 10 | 1.362 | 0.136 | ||
| Lack-of-Fit | 5 | 1.362 | 0.272 | * | * |
| Pure Error | 5 | 0.000 | 0.000 | ||
| Total | 19 | 548.103 | |||
| *: not applicable (NA). |
Regression equation
In order to assess the influence of the thermal radiation parameter, Eckert number, and thermal slip factor on the response variable, the response surface regression analysis was implemented in Fig. 34. The model’s statistical significance was confirmed by an R2 value of 99.75%, an adjusted R2 of 99.53%, and a predicted R2 of 97.67%, which indicates an exceptional model fit. The ANOVA results demonstrated that most of the linear, quadratic, and interaction terms were statistically significant (p < 0.0001). However, the quadratic terms Rd2 and Ec2 were not statistically significant, as their p-values were greater than 0.0001. The most significant effect was exhibited among the linear terms (F = 426.70), followed by Ec (F = 64.16) and (F = 2858.88). The strongest nonlinear effect was indicated by the quadratic term (F = 293.52), which exhibited the highest influence. Rd∗ (F = 119.87) was the most prevalent interaction effect, followed by Ec∗ (F = 21.86) and Rd ∗ Ec (F = 3.36). The interaction effects were substantial. The model’s adequacy is confirmed by a nonsignificant lack of fit, as the final regression equation effectively predicts system behavior. The Nusselt number’s variation with Ec and Rd is illustrated in the contour and surface plot Fig. 35, Fig. 36, Fig. 37 and Fig. 38. The Nusselt number (
Figure 34: Residual analysis plots for the Nusselt number (
Figure 35: (Color online) contour plot of
Figure 36: (Color online) surface plot of
Figure 37: (Color online) contour plot of
Figure 38: (Color online) surface plot of
5.3 Response Surface Regression: Shx Versus Cr, Sc and λ3
Summary of the model
| S | R2 | R2 (Adj.) | R2 (Pred.) |
| 0.0373484 | 99.31% | 98.69% | 97.31% |
Analysis of variance
| Source | DF | Adj. SS | Adj. MS | F-Value | p-Value |
| Model | 9 | 2.00917 | 0.223242 | 160.04 | 1.3 × 10−9 |
| Linear | 3 | 1.71121 | 0.570404 | 408.92 | 9.3 × 10−11 |
| Sc | 1 | 0.83901 | 0.839008 | 601.48 | 2.9 × 10−10 |
| Cr | 1 | 0.03647 | 0.036471 | 26.15 | 0.000455 |
| 1 | 0.83573 | 0.835732 | 599.13 | 3.0 × 10−10 | |
| Square | 3 | 0.03492 | 0.011641 | 8.35 | 0.004466 |
| Sc ∗ Sc | 1 | 0.01033 | 0.010326 | 7.40 | 0.022 |
| Cr ∗ Cr | 1 | 0.00005 | 0.000051 | 0.04 | 0.853 |
| 1 | 0.03090 | 0.030899 | 22.15 | 0.021549 | |
| 2-Way Interaction | 3 | 0.26304 | 0.087680 | 62.86 | 0.845489 |
| Sc ∗ Cr | 1 | 0.00072 | 0.000720 | 0.52 | 0.487358 |
| Sc ∗ | 1 | 0.25145 | 0.251448 | 180.26 | 1.0 × 10−7 |
| Cr ∗ | 1 | 0.01087 | 0.010872 | 7.79 | 0.019085 |
| Error | 10 | 0.01395 | 0.001395 | ||
| Lack-of-Fit | 5 | 0.01395 | 0.002790 | * | * |
| Pure Error | 5 | 0.00000 | 0.000000 | ||
| Total | 19 | 2.02312 | |||
| *: not applicable (NA). |
Regression equation
Fig. 39 illustrates the residual analysis for the Sherwood number, and the response surface regression analysis indicates a highly accurate model fit, achieving an R2 value of 99.31%, an altered R2 of 98.69% and an expected R2 of 97.31%. The ANOVA results confirm the statistical significance of most of the terms (p < 0.0001), except for the quadratic term Cr ∗ Cr (p = 0.853) and Sc ∗ Cr (p = 0.487358). Among the linear terms, the Schmidt number Sc exhibits the highest influence on the response variable, with an F-value of 601.48, followed by the concentration slip factor
Figure 39: Residual analysis plots for the Sherwood number (
Figure 40: (Color online) contour plot of
Figure 41: (Color online) surface plot of
Figure 42: (Color online) contour plot of
Figure 43: (Color online) surface plot of
An elevated Sc indicates a fluid characterized by reduced mass diffusivity, resulting in a thinner concentration boundary sheet and a heightened solutal gradient at the wall. The chemical reaction improves diffusive transport by accelerating the rate at which species are eliminated (in the case of destructive reactions), i.e., both Sc and Cr have a positive influence on the Sherwood number (
This investigation examined the thermal and species transport phenomena in a Casson-type hybrid nanofluid that contained copper (Cu) and gold (Au) nanoparticles. The nanoparticles were propelled by an elongating surface that was time-dependent. The work objectively evaluates the synergistic effects of the Casson factor and the unsteadiness constraint on transport phenomena through a comprehensive graphical and tabular analysis. The results demonstrate the combined impact of the two factors on the momentum contour, nonlinear temperature distributions, and concentration gradients that are susceptible to both. The study is significant in that it illustrates the interaction between radiative flux and response rate, as well as velocity slip, temperature slip, and concentration slip, to establish multiple transport regimes. Certain findings provide novel perspectives on optimizing systems that exhibit operationally controllable characteristics.
- 1.Both the nanofluid (NF) and hybrid nanofluid (HNF) portray a decrease in momentum as the suction and unsteadiness constraint upsurges.
- 2.The Casson rheological parameter and velocity slip coefficient increase the thickness of thermal and solutal boundary sheets due to increased diffusive transport mechanisms that allow for higher heat and mass dispersion.
- 3.The porosity constraint shows an inverse relationship with momentum and a direct relationship with thermal and mass distribution.
- 4.In the absence of magnetic influences, movement designs show regularly spaced, organized streamlines that are typical of unobstructed motion. The introduction of a magnetic field causes Lorentz-force-induced disturbances, which result in dispersed and uneven streamlines that indicate movementretardation.
- 5.Chemical reactions and solutal slip work together to thin the species boundary sheet by encouraging reactive species consumption while reducing wall-normal diffusion.
- 6.The regression model exhibited remarkable precision, with R2 values surpassing 99%, signifying a robust relationship between predicted and actual values.
- 7.The ANOVA results confirmed the model’s statistical significance, highlighting the major influence of Schmidt number on mass transfer and the thermal slip factor on heat transfer.
- 8.Contour and surface plots demonstrated complex interactions among parameters, showing that the Nusselt number diminishes as the temperature slip constraint rises, whereas the Sherwood number escalates with the Schmidt number and chemical reaction.
- 9.The RSM accurately forecasts system performance, offering a framework for optimization that improves heat transfer efficiency and reduces frictional losses.
The results emphasize the promising biomedical uses of Casson hybrid nanofluids, especially in cancer treatments that rely on hyperthermia, where accurate thermal control is essential. The results of this study contribute to the development of effective hybrid nanofluid-based cooling and heating systems for medical and industrial uses.
Acknowledgement:
Funding Statement: The authors received no specific funding for this study.
Author Contributions: The authors confirm contribution to the paper as follows: Conceptualization, methodology, validation, formal analysis, data curation, writing, original draft preparation: Pennelli Saila Kumari and Shaik Mohammed Ibrahim; Software, Writing, review, visualization, editing: Bhavanam Naga Lakshmi; Investigation, resources and supervision: Shaik Mohammed Ibrahim and Giulio Lorenzini. All authors reviewed and approved the final version of the manuscript.
Availability of Data and Materials: All data are available within the manuscript.
Ethics Approval: Not applicable.
Conflicts of Interest: The authors declare no conflicts of interest.
Nomenclature
| constant stretching rate | |
| Free stream rate | |
| Specific heat at non varying pressure (J·kg−1·K−1) | |
| Momentum-components in x, y directions (m·s−1) | |
| Velocity at the wall (m·s−1) | |
| Ambient fluid velocity (m·s−1) | |
| Intensity of magnetic field | |
| Chemical reaction constraint | |
| Prandtl number | |
| Suction momentum | |
| Similarity variable | |
| Viscosity of the plastic dynamic (kg·M−1·s−1) | |
| Component deformation Product | |
| Acceleration due to gravity (m·s−2) | |
| Solutal of the fluid (kg·m−3) | |
| Concentration level of fluid at surface (kg·m−3) | |
| solutal level of fluid far away from the surface (kg·m−3) | |
| Absorption coefficient | |
| Fluid thermal conductivity (W·m−1·K−1) | |
| Stream function, (m2·s−1) | |
| Characteristic function | |
| Dimensionless velocity | |
| Nanoparticles mass density, (kg·m−3) | |
| Nanoparticles heat capacity | |
| Stefan-Boltzmann constant | |
| fluid density | |
| fluid heat capacity | |
| Electrical conductivity, (S·m−1) | |
| radiative heat flux | |
| Magnetic field constraint | |
| Kp | Porosity constraint |
| Unsteadiness constraint | |
| λ1 | Momentum slip constraint |
| λ2 | Temperature slip constraint |
| λ3 | Concentration slip constraint |
| Schmidt number | |
| Thermal Radiation constraint | |
| Fluid thermal diffusivity | |
| Eckert number | |
| Local Nusselt number | |
| Product based non-Newtonian Critical value model | |
| Sherwood number | |
| Cfx | Skin friction factor |
| Fluid thermal | |
| Convective fluid thermal | |
| Ambient fluid temperature | |
| Surfaceheat flux (Wm−2) | |
| Surface mass flux | |
| Surface shear stress | |
| Dimensionless stream function | |
| Casson constraint | |
| Nanofluid to base fluid heat Capability ratio | |
| kinematic viscosity (m2·s−1) | |
| Dynamic viscosity | |
| Subscripts | |
| Dimensionless Temperature | |
| Dimensionless solutal | |
| Hnf | Hybrid nano fluid |
| Free stream | |
| nanoparticle | |
| fluid | |
| wall |
References
1. Lu G , Wang XD , Duan YY . A critical review of dynamic wetting by complex fluids: from Newtonian fluids to non-Newtonian fluids and nanofluids. Adv Colloid Interface Sci. 2016; 236: 43– 62. doi:10.1016/j.cis.2016.07.004. [Google Scholar] [CrossRef]
2. Rauf A , Abbas Z , Shehzad SA . Utilization of Maxwell-Cattaneo law for MHD swirling flow through oscillatory disk subject to porous medium. Appl Math Mech Engl Ed. 2019; 40( 6): 837– 50. doi:10.1007/s10483-019-2488-9. [Google Scholar] [CrossRef]
3. Khan A , Shah RA , Alam MK , Ahmed H , Shahzad M , Rehman S , et al. Computational investigation of an unsteady non-Newtonian and non-isothermal fluid between coaxial contracting channels: a PCM approach. Results Phys. 2021; 28: 104570. doi:10.1016/j.rinp.2021.104570. [Google Scholar] [CrossRef]
4. Abbas SZ , Khan WA , Waqas M , Irfan M , Asghar Z . Exploring the features for flow of Oldroyd-B liquid film subjected to rotating disk with homogeneous/heterogeneous processes. Comput Methods Programs Biomed. 2020; 189: 105323. doi:10.1016/j.cmpb.2020.105323. [Google Scholar] [CrossRef]
5. Choi SUS , Eastman JA . Enhancing thermal conductivity of fluids with nanoparticles. In: Proceedings of the Developments and Applications of Non-Newtonian Flows; 1995 Nov 12–17; San Francisco, CA, USA. New York, NY, USA: American Society of Mechanical Engineers; 1995. p. 99– 105. doi:10.1115/imece1995-0926. [Google Scholar] [CrossRef]
6. Said Z , Sundar LS , Tiwari AK , Ali HM , Sheikholeslami M , Bellos E , et al. Recent advances on the fundamental physical phenomena behind stability, dynamic motion, thermophysical properties, heat transport, applications, and challenges of nanofluids. Phys Rep. 2022; 946: 1– 94. doi:10.1016/j.physrep.2021.07.002. [Google Scholar] [CrossRef]
7. Rashidi MM , Ghahremanian S , Toghraie D , Roy P . Effect of solid surface structure on the condensation flow of Argon in rough nanochannels with different roughness geometries using molecular dynamics simulation. Int Commun Heat Mass Transf. 2020; 117: 104741. doi:10.1016/j.icheatmasstransfer.2020.104741. [Google Scholar] [CrossRef]
8. Jazaa Y , Rehman S , Hashim , Albouchi F . On the enhancement of heat transport and entropy generation of the thin film flow of partially ionized non-Newtonian hybrid nanofluid. J Taiwan Inst Chem Eng. 2024; 157: 105412. doi:10.1016/j.jtice.2024.105412. [Google Scholar] [CrossRef]
9. Guo Z . A review on heat transfer enhancement with nanofluids. J Enh Heat Transf. 2020; 27( 1): 1– 70. doi:10.1615/jenhheattransf.2019031575. [Google Scholar] [CrossRef]
10. Narankhishig Z , Ham J , Lee H , Cho H . Convective heat transfer characteristics of nanofluids including the magnetic effect on heat transfer enhancement—a review. Appl Therm Eng. 2021; 193: 116987. doi:10.1016/j.applthermaleng.2021.116987. [Google Scholar] [CrossRef]
11. Alawee WH , Jaber AA , Omara ZM , Mohammed SA , Dhahad HA , Khan ZH , et al. Optimizing water resources for sustainable desalination: the integration of expert systems and solar energy in experimental applications. Desalin Water Treat. 2024; 320: 100683. doi:10.1016/j.dwt.2024.100683. [Google Scholar] [CrossRef]
12. Chu YM , Khan MI , Abbas T , Sidi MO , Alharbi KAM , Alqsair UF , et al. Radiative thermal analysis for four types of hybrid nanoparticles subject to non-uniform heat source: Keller box numerical approach. Case Stud Therm Eng. 2022; 40: 102474. doi:10.1016/j.csite.2022.102474. [Google Scholar] [CrossRef]
13. Naganthran K , Nazar R , Siri Z , Hashim I . Entropy analysis and melting heat transfer in the carreau thin hybrid nanofluid film flow. Mathematics. 2021; 9( 23): 3092. doi:10.3390/math9233092. [Google Scholar] [CrossRef]
14. Haneef M , Ali Madkhali H , Salmi A , Alharbi SO , Malik MY . Numerical study on heat and mass transfer in Maxwell fluid with tri and hybrid nanoparticles. Int Commun Heat Mass Transf. 2022; 135: 106061. doi:10.1016/j.icheatmasstransfer.2022.106061. [Google Scholar] [CrossRef]
15. Gohar , Khan TS , Sene N , Mouldi A , Brahmia A . Heat and mass transfer of the darcy-forchheimer casson hybrid nanofluid flow due to an extending curved surface. J Nanomater. 2022; 2022: 3979168. doi:10.1155/2022/3979168. [Google Scholar] [CrossRef]
16. Rashad AM , Nafe MA , Eisa DA . Heat variation on MHD Williamson hybrid nanofluid flow with convective boundary condition and Ohmic heating in a porous material. Sci Rep. 2023; 13: 6071. doi:10.1038/s41598-023-33043-z. [Google Scholar] [CrossRef]
17. Ummeda P , Ontela S . Mixed convective thermally radiative viscoelastic hybrid nanofluid flow in a vertical channel: entropy generation analysis. Mod Phys Lett B. 2024; 38( 4): 2350264. doi:10.1142/s0217984923502640. [Google Scholar] [CrossRef]
18. Gumber P , Yaseen M , Rawat SK , Kumar M . Heat transfer in micropolar hybrid nanofluid flow past a vertical plate in the presence of thermal radiation and suction/injection effects. Part Differ Equ Appl Math. 2022; 5: 100240. doi:10.1016/j.padiff.2021.100240. [Google Scholar] [CrossRef]
19. Asjad MI , Riaz A , Alnahdi AS , Eldin SM . New solutions of fractional Jeffrey fluid with ternary nanoparticles approach. Micromachines. 2022; 13( 11): 1963. doi:10.3390/mi13111963. [Google Scholar] [CrossRef]
20. Khan WA , Tabrez M , Hussain I , Ali M , Waqas M . Analysis of thermal conductivity performance for magnetized Sutterby fluid capturing magnetic dipole and viscous dissipation aspects. Mod Phys Lett B. 2024; 38( 16): 2341017. doi:10.1142/s0217984923410178. [Google Scholar] [CrossRef]
21. Ellahi R , Zeeshan A , Hussain F , Asadollahi A . Peristaltic blood flow of couple stress fluid suspended with nanoparticles under the influence of chemical reaction and activation energy. Symmetry. 2019; 11( 2): 276. doi:10.3390/sym11020276. [Google Scholar] [CrossRef]
22. Akbar NS , Akram J , Hussain MF , Maraj EN , Muhammad T . Thermal storage study and enhancement of heat transfer through hybrid Jeffrey nanofluid flow in ducts under peristaltic motion with entropy generation. Therm Sci Eng Prog. 2024; 49: 102463. doi:10.1016/j.tsep.2024.102463. [Google Scholar] [CrossRef]
23. Madiha Takreem K , Venkateswarlu B , Misra A , Satya Narayana PV , Harish Babu D . Optimization of heat transfer characteristics of Casson hybrid nanofluid flow over a porous exponentially elongating surface using RSM approach. J Therm Anal Calorim. 2025; 150( 3): 2133– 49. doi:10.1007/s10973-024-13840-y. [Google Scholar] [CrossRef]
24. Vishalakshi AB , Mahesh R , Mahabaleshwar US , Rao AK , Pérez LM , Laroze D . MHD hybrid nanofluid flow over a stretching/shrinking sheet with skin friction: effects of radiation and mass transpiration. Magnetochemistry. 2023; 9( 5): 118. doi:10.3390/magnetochemistry9050118. [Google Scholar] [CrossRef]
25. Shojaie Chahregh H , Dinarvand S . TiO2-Ag/blood hybrid nanofluid flow through an artery with applications of drug delivery and blood circulation in the respiratory system. Int J Numer Meth Heat Fluid Flow. 2020; 30( 11): 4775– 96. doi:10.1108/hff-10-2019-0732. [Google Scholar] [CrossRef]
26. Rauf A , Hussain F , Mushtaq A , Ali Shah N , Ali MR . MHD mixed convection flow for Maxwell Hybrid nanofluid with Soret, Dufour and Morphology effects. Arab J Chem. 2023; 16( 8): 104965. doi:10.1016/j.arabjc.2023.104965. [Google Scholar] [CrossRef]
27. Hanif H , Ali Lund L , Mahat R , Shafie S . Heat transfer analysis of Maxwell hybrid nanofluid with fractional Cattaneo heat flux. Alex Eng J. 2023; 72: 545– 57. doi:10.1016/j.aej.2023.04.022. [Google Scholar] [CrossRef]
28. Habib S , Nasir S , Khan Z , Berrouk A , Islam S , Aamir A . Enhancing thermal transport in chemically reacting nanoparticles using the energy source and Cattaneo-Christov heat flux model. Energy Convers Manag X. 2024; 24: 100807. doi:10.1016/j.ecmx.2024.100807. [Google Scholar] [CrossRef]
29. Khan I . Shape effects of MoS 2 nanoparticles on MHD slip flow of molybdenum disulphide nanofluid in a porous medium. J Mol Liq. 2017; 233: 442– 51. doi:10.1016/j.molliq.2017.03.009. [Google Scholar] [CrossRef]
30. Chamkha AJ , Ismael MA . Magnetic field effect on mixed convection in lid-driven trapezoidal cavities filled with a Cu–water nanofluid with an aiding or opposing side wall. J Therm Sci Eng Appl. 2016; 8( 3): 031009. doi:10.1115/1.4033211. [Google Scholar] [CrossRef]
31. Mabood F , Yusuf TA , Khan WA . Cu–Al2O3–H2O hybrid nanofluid flow with melting heat transfer, irreversibility analysis and nonlinear thermal radiation. J Therm Anal Calorim. 2021; 143( 2): 973– 84. doi:10.1007/s10973-020-09720-w. [Google Scholar] [CrossRef]
32. Shatnawi TAM , Abbas N , Shatanawi W . Mathematical analysis of unsteady stagnation point flow of radiative casson hybrid nanofluid flow over a vertical Riga sheet. Mathematics. 2022; 10( 19): 3573. doi:10.3390/math10193573. [Google Scholar] [CrossRef]
33. Nadeem M , Franco AT , Siddique I , Fiidow MA , Garcia-Blanco YJ , Shakoor B . Activation energy effects on torsional third-grade hybrid nanofluid flow in concentric porous pipes: a sensitivity analysis. Results Eng. 2026; 29: 108778. doi:10.1016/j.rineng.2025.108778. [Google Scholar] [CrossRef]
34. Yahaya RI , Mustafa MS , Md Arifin N , Pop I , Md Ali F , Mohamed Isa SSP . Heat transfer optimization using RSM for hybrid nanofluid flow impinging obliquely on a permeable shrinking sheet. J Adv Res Numer Heat Trans. 2025; 29( 1): 1– 15. doi:10.37934/arnht.29.1.115. [Google Scholar] [CrossRef]
35. Agbaje TM , Leach PGL . Numerical investigation of natural convection viscoelastic Jeffrey’s nanofluid flow from a vertical permeable flat plate with heat generation, thermal radiation, and chemical reaction. Abstr Appl Anal. 2020; 2020: 9816942. doi:10.1155/2020/9816942. [Google Scholar] [CrossRef]
36. Fatunmbi EO , Salawu SO . Analysis of hydromagnetic micropolar nanofluid flow past a nonlinear stretchable sheet and entropy generation with Navier slips. Int J Model Simul. 2022; 42( 3): 359– 69. doi:10.1080/02286203.2021.1905490. [Google Scholar] [CrossRef]
37. Ramzan M , Saeed A , Kumam P , Ahmad Z , Junaid MS , Khan D . Influences of Soret and Dufour numbers on mixed convective and chemically reactive Casson fluids flow towards an inclined flat plate. Heat Trans. 2022; 51( 5): 4393– 433. doi:10.1002/htj.22505. [Google Scholar] [CrossRef]
38. Waini I , Alabdulhady S , Ishak A , Pop I . Viscous dissipation effects on hybrid nanofluid flow over a non-linearly shrinking sheet with power-law velocity. Heliyon. 2023; 9( 10): e20910. doi:10.1016/j.heliyon.2023.e20910. [Google Scholar] [CrossRef]
39. Alzahrani AK , Abbas Z , Ullah MZ . Chemically reactive two-phase flow of viscous-Casson fluids in a rotating channel. Alex Eng J. 2023; 62: 403a– 13. doi:10.1016/j.aej.2022.07.036. [Google Scholar] [CrossRef]
40. Alali E , Megahed AM . MHD dissipative Casson nanofluid liquid film flow due to an unsteady stretching sheet with radiation influence and slip velocity phenomenon. Nanotechnol Rev. 2021; 11( 1): 463– 72. doi:10.1515/ntrev-2022-0031. [Google Scholar] [CrossRef]
41. Devi SU , Devi SA . Heat transfer enhancement of Cu-Al2O3/water hybrid nanofluid flow over a stretching sheet. J Niger Math Soc. 2017; 6( 2): 419– 33. [Google Scholar]
42. Shaiq S . Role of (Cu–Au/H2O) hybrid nanofluid in mass and heat transmission along an unsteady nonlinear curved stretching surface with velocity slip dynamics: a thermal numerical inquiry. Int J Ambient Energy. 2025; 46( 1): 2512846. doi:10.1080/01430750.2025.2512846. [Google Scholar] [CrossRef]
Cite This Article
Copyright © 2026 The Author(s). Published by Tech Science Press.This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Submit a Paper
Propose a Special lssue
View Full Text
Download PDF
Downloads
Citation Tools