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Scaffolds and Fluid Flow in Cardiac Tissue Engineering

Milica Radisic1,2, Gordana Vunjak-Novakovic3

Institute of Biomaterials and Biomedical Engineering and Department of Chemical Engineering and Applied Chemistry, Universityof Toronto. Havard-MIT Division of Health Science and Technology.
Massachusetts Institute of Technology
Correspondence author, Department of Biomedical Engineering, Columbia University, New York, NY 10027,

Fluid Dynamics & Materials Processing 2006, 2(1), 1-16.


To engineer cardiac tissue in vitro with properties approaching those of native tissue, it is necessary to reproduce many of the conditions found in vivo. In particular, cell density must be sufficiently high to enable contractility, which implies a three-dimensional culture with a sufficient oxygen and nutrient supply. In this review, hydrogels and scaffolds that support high cell densities are examined followed by a discussion on the utility of scaffold perfusion to satisfy high oxygen demand of cardiomyocytes and an overview of new bioreactors developed in our laboratory to accomplish this task more simply.

Cite This Article

APA Style
Radisic, M., Vunjak-Novakovic, G. (2006). Scaffolds and fluid flow in cardiac tissue engineering. Fluid Dynamics & Materials Processing, 2(1), 1-16.
Vancouver Style
Radisic M, Vunjak-Novakovic G. Scaffolds and fluid flow in cardiac tissue engineering. Fluid Dyn Mater Proc. 2006;2(1):1-16
IEEE Style
M. Radisic and G. Vunjak-Novakovic, "Scaffolds and Fluid Flow in Cardiac Tissue Engineering," Fluid Dyn. Mater. Proc., vol. 2, no. 1, pp. 1-16. 2006.

cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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