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Water-Based Environmentally Friendly Pesticide Formulations Based on Cyclodextrin/Pesticide Loading System

Xinyu Guo1, Zhe Sun2, Rui Zhao2, Hongyi Shang2, Jiangyu Liu2, Yong Xu2, Laihua Liu1,*, Xuemin Wu2,*

1 Key Lab of Plant-Soil Interaction, MOE, Center for Resources, Environment and Food Security, College of Resources and Environmental Sciences, China Agricultural University, Beijing, 100193, China
2 Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing, 100193, China

* Corresponding Authors: Laihua Liu. Email: email; Xuemin Wu. Email: email
This paper is dedicated to the 70th Anniversary of Pesticide Science in China Agricultural University

(This article belongs to this Special Issue: Renewable Material from Agricultural Waste and By-Product and Its Applications)

Journal of Renewable Materials 2023, 11(2), 777-789.


Difenoconazole (DIF) is a representative variety of broad-spectrum triazole fungicides and liposoluble pesticides. However, the water solubility of DIF is so poor that its application is limited in plant protection. In addition, the conventional formulations of DIF always contain abundant organic solvents, which may cause pollution of the environment. In this study, two DIF/cyclodextrins (CDs) inclusion complexes (ICs) were successfully prepared, which were DIF/β-CD IC and DIF/hydroxypropyl-β-CD IC (DIF/HP-β-CD IC). The effect of cyclodextrins on the water solubility and the antifungal effect of liposoluble DIF pesticide were investigated. According to the phase solubility test, the molar ratio and apparent stability constant of ICs were obtained. Fourier transform infrared spectroscopy, thermal gravity analysis, X-ray diffraction and scanning electron microscopy were used systematically to characterize the formation and characteristics of ICs. The results noted that DIF successfully entered the cavities of two CDs. In addition, the antifungal effect test proved the better performance of DIF/HP-β-CD IC, which exceeded that of DIF emulsifiable concentrate. Therefore, our study provides informative direction for the intelligent use of liposoluble pesticides with cyclodextrins to develop water-based environmentally friendly formulations.


Cite This Article

Guo, X., Sun, Z., Zhao, R., Shang, H., Liu, J. et al. (2023). Water-Based Environmentally Friendly Pesticide Formulations Based on Cyclodextrin/Pesticide Loading System. Journal of Renewable Materials, 11(2), 777–789.

cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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