• Journal Logo

Open Access iconOpen Access

ARTICLE

crossmark

Effect of Resistance Training and Spirulina platensis on Expression of IL-6, Gp130 Cytokines, JAK-STAT Signaling in Male Rats Skeletal Muscle

Abdossaleh Zar1, Fatemeh Ahmadi1, Forouzan Karimi2,*, Mozhgan Ahmadi3, Roger Ramsbottom4

1 Department of Sport Science, School of Literature and Humanities, Persian Gulf University, Boushehr, 75169, Iran
2 Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 19857-17443, Iran
3 Department of Physical Education and Sport Science, Yadegar-e-Imam Khomeini (RAH) Shahre-Rey Branch, Islamic Azad University, Tehran, 18155, Iran
4 Department of Sport, Health Sciences and Social Work, Oxford Brookes University, Oxford, OX3 0BP, UK

* Corresponding Author: Forouzan Karimi. Email: email

Molecular & Cellular Biomechanics 2022, 19(1), 51-59. https://doi.org/10.32604/mcb.2022.018345

Abstract

The effect of resistance training and a herbal supplement on muscular signaling pathways are limited. We investigated the expression of IL-6, Gp130, JAK and STAT after resistance training, and Spirulina platensis supplementation in animal muscle. Thirty-two male Sprague Dawley rats (weight: 290 ± 20 g, and 9 weeks of age) were divided into four groups: control (CO; n = 8), Spirulina platensis supplementation (SP; n = 8), resistance exercise (RE; n = 8), and Spirulina platensis + resistance exercise (SP + RE; n = 8). The resistance exercise group trained five sessions each week for eight weeks. Spirulina 200 mg kg−1 d−1 was used in the SP and SP + RE groups. Gene expression was measured by real-time PCR following the last training session. One-way ANOVA test with Tukey’s post-hoc test were used for analysis of data (SPSS, version, 21). Data analysis revealed that the expression of IL-6 (P = 0.001), Gp130 (P = 0.001), JAK (P = 0.0001) and STAT (P = 0.004) increased significantly in the RE group. The expression of IL-6 (P = 0.018), JAK (P = 0.001) and STAT (P = 0.001) in SP + RE group also increased significantly (P ≤ 0.05). SP showed a significant increase in Gp130 (P = 0.001) and STAT (P = 0.001). Supplementation by Spirulina platensis may enhance muscle accretion during resistance training.

Keywords


Cite This Article

Zar, A., Ahmadi, F., Karimi, F., Ahmadi, M., Ramsbottom, R. (2022). Effect of Resistance Training and Spirulina platensis on Expression of IL-6, Gp130 Cytokines, JAK-STAT Signaling in Male Rats Skeletal Muscle. Molecular & Cellular Biomechanics, 19(1), 51–59.



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • 2053

    View

  • 1308

    Download

  • 0

    Like

Share Link